Innovation of Natural Product as Suppository Base

Abstract

Indian system of traditional medicine has its unique position in the history of medicine. Similarly ghee's role as a medicament holds the same age, apart from its nutritional values it possesses best medicinal properties like enhancing the physical and mental strength and also in removing the impurities from our body. Ghee increases intelligence, memory power and the other uses include rejuvenation of skin, boosts body energy, detoxifies and nourishes body, increases clarity of voice, increases semen secretion, effective against eye disorders and wound healing activity, decreases the LDL cholesterol in plasma, increases gastric acid secretion for digestion and improves appetite 1-4. Suppositories are the solid dosage forms which can be inserted into the cavity of vagina or rectum or urethra for local or systemic effect, where it melts at body temperature and disperse or dissolve in cavity fluids to release the drug. Generally there are three types of suppositories namely vaginal, rectal and urethral suppositories. Semisolid bases act as a vehicle to carry drug which includes the fatty bases, water soluble bases, emulsion bases, hydrocarbon bases, that are selected based on the physicochemical properties of the drug and the desired therapeutic drug release effect. The specifications for an ideal base includes non-toxicity to tissues, non-irritation to mucous membranes, compatibility with variety of drugs, melting point range near to body temperature,