Inner City Asthma

Gergen, Peter J.; Togias, Alkis

doi:10.1016/j.iac.2014.09.006

Cited by 55 publications

(28 citation statements)

References 92 publications

(92 reference statements)

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“…The prevalence of asthma in the United States has increased from 7.3% in 2001 to 8.4% in 2010 (2). Currently, asthma affects over 300 million people and one out of every 250 deaths worldwide is attributed to this disease.…”

Section: Introductionmentioning

confidence: 99%

Cockroach allergen exposure and risk of asthma

Danh

Zhao

Gao

2016

Allergy

131

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Cockroach sensitization is an important risk factor for the development of asthma. However, its underlying immune mechanisms and the genetic etiology for differences in allergic responses remain unclear. Cockroach allergens identification and their expression as biologically active recombinant proteins has provided a basis for studying the mechanisms regarding cockroach allergens induced allergic sensitization and asthma. Glycans in allergens may play a crucial role in the immunogenicity of allergic diseases. Protease-activated receptor (PAR)-2, Toll-like receptor (TLR), and C-type lectin receptors have been suggested to be important for the penetration of cockroach allergens through epithelial cells to mediate allergen uptake, dendritic cell maturation, antigen presenting cell (APC) function in T cell polarization, and cytokine production. Environmental pollutants, which often co-exist with the allergen, could synergistically elicit allergic inflammation, and aryl hydrocarbon receptor (AhR) activation and signaling may serve as a link between these two elements. Genetic factors may also play an important role in conferring the susceptibility to cockroach sensitization. Several genes have been associated with cockroach sensitization and asthma-related phenotypes. In this review, we will discuss the epidemiological evidence for cockroach allergen-induced asthma, cockroach allergens, the mechanisms regarding cockroach allergens induced innate immune responses, and the genetic basis for cockroach sensitization.

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Section: Introductionmentioning

confidence: 99%

Cockroach allergen exposure and risk of asthma

Danh

Zhao

Gao

2016

Allergy

131

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“…These and more recent studies have further identified cockroach allergens as one of the strongest risk factors for allergic sensitization and asthma morbidity in low-income, urban populations [86, 118–122]. Although some investigations have suggested that mouse allergen may be more clinically important in these populations [53•, 123], co-exposure to both allergens is common, and more than 50% of urban children with asthma are sensitized to one or the other [119].…”

Section: Bedroom Allergen Exposuresmentioning

confidence: 99%

Bedroom Allergen Exposure Beyond House Dust Mites

Salo

Cohn²,

Zeldin

2018

Curr Allergy Asthma Rep

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Purpose of the review: The review provides insight into recent findings on bedroom allergen exposures, primarily focusing on pet, pest and fungal exposures. Recent findings: Large-scale studies and improved exposure assessment technologies, including measurement of airborne allergens and of multiple allergens simultaneously, has extended our understanding of indoor allergen exposures and their impact on allergic disease. Practical, streamlined methods for exposure reduction have shown promise in some settings, and potential protective effects of early-life exposures have been further elucidated through the investigation of specific bacterial taxa. Advances in molecular allergology have yielded novel data on sensitization profiles and cross-reactivity. Summary: The role of indoor allergen exposures in allergic disease is complex and remains incompletely understood. Advancing our knowledge of various co-exposures, including the environmental and host microbiome, that interact with allergens in early life will be crucial for the development of efficacious interventions to reduce the substantial economic and social burden of allergic diseases including asthma.

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“…In the United States, 21.2% in Mexican Americans, 24.3% in non-Hispanic blacks, and 14% in non-Hispanic whites are obese [58]. Interestingly, worse asthma control is uniformly associated with increased body mass index in boys.…”

Section: Obesitymentioning

confidence: 99%

“…Obviously, effects of ethnicity might be confounded with those effects associated with low socioeconomic status. Lower-income, minority communities have higher exposures to environmental pollutants because of the disproportionately higher numbers of toxic waste dumps, major highways, bus terminals, industry, and so forth located nearby [58]. In USA, being a member of a racial/ethnic minority group (non-Hispanic black 4.4%, Hispanic 5%, non-Hispanic white 3.1%), being foreign born (5.1 vs 3.5% native born), and speaking a language other than English at home (Spanish 5.1% vs English 3.3%) increases the probability of living close to a major highway [64].…”

Section: Environmental Factorsmentioning

confidence: 99%

Influence of ethnicity on response to asthma drugs

Cazzola¹,

Rogliani

Sanduzzi

et al. 2015

Expert Opinion on Drug Metabolism & Toxicology

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Health-care professionals might never use the treatment in their patients irrespective of their ethnicity and thus inadvertently increase ethnic health inequality. However, our understanding of whether and/or how ethnicity influences pharmacological response to asthma therapeutics is still very scarce. A holistic, integrative systems biology approach that combines large-scale molecular profiling traits (e.g., transcriptomic, proteomic, metabolomic traits) and genetic variants could help to personalize the treatment of asthmatic patients regardless of race/ethnicity.

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Inner City Asthma

Cited by 55 publications

References 92 publications

Cockroach allergen exposure and risk of asthma

Cockroach allergen exposure and risk of asthma

Bedroom Allergen Exposure Beyond House Dust Mites

Influence of ethnicity on response to asthma drugs

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