Erin C. Steinbach, Taku Kobayashi, Steven M. Russo, Shehzad Z. Sheikh, Gregory R. Gipson, Samantha T. Kennedy, Jennifer K. Uno, Yoshiyuki Mishima, Luke B. Borst, Bo Liu, Hans Herfarth, Jenny P. Y. Ting, R. Balfour Sartor, Scott E. Plevy et al.
The p110δ subunit of class IA phosphoinositide 3-kinase modulates signaling in innate immune cells. We previously demonstrated that mice harboring a kinase-dead p110δ subunit (p110δKD) develop spontaneous colitis. Macrophages contributed to the Th1/Th17 cytokine bias in p110δKD mice through increased IL-12 and IL-23 expression. Here, we show that the enteric microbiota is required for colitis development in germ free p110δKD mice. Colonic tissue and macrophages from p110δKD mice produce significantly less IL-…
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