Innate immune cells express IL-17A/F in acute generalized exanthematous pustulosis and generalized pustular psoriasis

Kakeda, Masato; Schlapbach, Christoph; Danelon, Gabriela; Tang, M.M.; Cecchinato, Valentina; Yawalkar, Nikhil; Uguccioni, Mariagrazia

doi:10.1007/s00403-014-1488-0

Cited by 40 publications

(30 citation statements)

References 24 publications

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“…The most important factor for the diagnosis is the quicker resolution time seen in AGEP. Recent studies described similarities in the pathogenesis of AGEP and GPP, like mutations in the IL-36Ra and an elevated expression of IL-17 [51]. DRESS typically presents with a morbilliform rash spreading from the face to the rest of the body, but might present with pustules as well.…”

Section: Clinical Features and Variantsmentioning

confidence: 99%

Acute Generalized Exanthematous Pustulosis: Pathogenesis, Genetic Background, Clinical Variants and Therapy

Feldmeyer

Heidemeyer

Yawalkar

2016

IJMS

162

204

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Acute generalized exanthematous pustulosis (AGEP) is a severe, usually drug-related reaction, characterized by an acute onset of mainly small non-follicular pustules on an erythematous base and spontaneous resolution usually within two weeks. Systemic involvement occurs in about 20% of cases. The course is mostly benign, and only in rare cases complications lead to life-threatening situations. Recent studies highlight the importance of genetic variations in interleukin-36 receptor antagonist gene (IL-36RN) in the pathogenesis of this disease. The physiopathology of AGEP remains unclear, but an involvement of innate and acquired immune cells together with resident cells (keratinocytes), which recruit and activate neutrophils via production of cytokines/chemokines such as IL-17, IL-36, granulocyte-macrophage colony-stimulating factor (GM-CSF), tumor necrosis factor alpha (TNFα) and chemokine (C-X-C motif) ligand 8 (CXCL8)/IL-8, has been postulated. Treatment is based on the removal of the causative drug, supportive care, infection prevention and use of potent topical or systemic steroids.

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Section: Clinical Features and Variantsmentioning

confidence: 99%

Acute Generalized Exanthematous Pustulosis: Pathogenesis, Genetic Background, Clinical Variants and Therapy

Feldmeyer

Heidemeyer

Yawalkar

2016

IJMS

162

204

View full text Add to dashboard Cite

show abstract

“…IL-17A has been demonstrated to participate in the pathological angiogenesis in rheumatoid arthritis, psoriasis and tumors (Numasaki et al 2005;Kim et al 2013;Varricchi et al 2015). In addition, IL-17A/F is expressed at the lesion of psoriasis, chronic obstructive pulmonary disease and rheumatoid arthritis (Chang et al 2014;Kakeda et al 2014;Sarkar et al 2014). Although the biological activities of IL-17A/F to promote angiogenesis-related endothelial cell functions seem to be slightly lower than those of IL-17A, IL-17A/F may also contribute to the pathological angiogenesis characterized in rheumatoid arthritis and psoriasis.…”

Section: Dmentioning

confidence: 99%

A Heterodimeric Cytokine, Consisting of IL-17A and IL-17F, Promotes Migration and Capillary-Like Tube Formation of Human Vascular Endothelial Cells

Numasaki

Tsukamoto

Tomioka

et al. 2016

Tohoku J. Exp. Med.

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“…In the pathogenesis of psoriasis, immunological factors are playing a key role. An increased serum level of several proinflammatory cytokines, such as interleukin (IL)-15 [7], IL-17 [8] and IL-22 [9] was found in certain studies. There is increasing evidence that IL-17 regulates inflammatory response in psoriasis, induces production and release of several cytokines, such as IL-6, granulocyte-colony stimulating factor (G-CSF), IL-1β, transforming growth factor (TGF)-β and tumor necrosis factor (TNF)- α, chemokines (IL-8, GRO-α, and MCP-1) and prostaglandins from fibroblasts, endothelial cells, keratinocytes, epithelial cells and macrophages [10, 11].…”

Section: Introductionmentioning

confidence: 99%

Are interleukin-15 and -22 a new pathogenic factor in pustular palmoplantar psoriasis?

Lesiak¹,

Bednarski²,

Pałczyńska³

et al. 2016

pdia

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IntroductionPustular palmoplantar psoriasis (PPP) is a rare type of psoriasis affecting mainly distal parts of the limbs. Despite numerous theories about etiology of PPP, the pathogenesis still remains unclear. Recent data indicate that interleukin (IL)-15, IL-17 and IL-22 enhance a proinflammatory response in certain skin inflammatory diseases such as psoriasis and atopic dermatitis. There is also evidence that anti-endomysial (anti-EMA) and anti-gliadin (AGA) antibodies are engaged in PPP development.AimTo assess IL-15, IL-17, IL-22 serum levels and evaluate the presence of anti-endomysial and anti-gliadin antibodies in patients with PPP.Material and methodsThe study group consisted of 20 females of the mean age of 51.8 suffering from PPP. Additionally 29 healthy individuals, age and sex matched, served as controls. ELISA was performed to evaluate serum IL-15, IL-17, IL-22 concentrations while an indirect immunofluorescence test (IIF) was used to determine anti-EMA and AGA presence.ResultsThe mean value of IL-15 and IL-22 serum concentrations was significantly higher in the study group than in the control group (IL-15: 6.48 vs. 4.88 pg/ml; IL-22: 81.47 vs. 4.90 pg/ml, respectively; p < 0.05 for all comparisons). The IL-17 serum level in the study group was higher when compared to the control group (2.0 vs. 0.75 pg/ml), however the results were not statistically significant (p = 0.26). There were no anti-EMA and AGA antibodies detected, both in the control and study group.ConclusionsThe results obtained may suggest involvement of IL-15 and IL-22 in the pathogenesis of PPP.

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Innate immune cells express IL-17A/F in acute generalized exanthematous pustulosis and generalized pustular psoriasis

Cited by 40 publications

References 24 publications

Acute Generalized Exanthematous Pustulosis: Pathogenesis, Genetic Background, Clinical Variants and Therapy

Acute Generalized Exanthematous Pustulosis: Pathogenesis, Genetic Background, Clinical Variants and Therapy

A Heterodimeric Cytokine, Consisting of IL-17A and IL-17F, Promotes Migration and Capillary-Like Tube Formation of Human Vascular Endothelial Cells

Are interleukin-15 and -22 a new pathogenic factor in pustular palmoplantar psoriasis?

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