Innate Immune Cell Collaborations Instigate Transplant Tolerance

Ochando, Jordi; Turnquist, Hēth

doi:10.1111/ajt.12912

Cited by 4 publications

(3 citation statements)

References 9 publications

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“…38,43 MDSCs express programmed death ligand-1 (PDL-1) and bind PD-1 expressed by Treg, upregulating Treg responses. 25,64,65 Indeed, MDSCs enhance PDL-1 mediated T cell suppression and blockade of PDL-1 inhibits MDSC-mediated suppression. 25,64–66…”

Section: Functionmentioning

confidence: 99%

“…It was hypothesized that tolerance was induced by MDSC-mediated T cell suppression via arginase-1 and Treg expansion via PD-L1 mediated pathways. 25,65,109 MDSCs played an important role in the establishment and maintenance of both chimerism and tolerance.…”

Section: Evidence For a Role Of Mdscs In Transplantationmentioning

confidence: 99%

“…70,118,119 As discussed above, Tregs are one of the primary mechanisms by which MDSCs mediate T cell suppression. 25,65,118 Depletion of MDSCs in cardiac tolerance models led to a failure of Treg development and tolerance. 25 This link between cell types is important because in many tolerance studies the stimulus for Treg upregulation remains unclear.…”

Section: Evidence For a Role Of Mdscs In Transplantationmentioning

confidence: 99%

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Myeloid-Derived Suppressor Cells and Their Potential Application in Transplantation

et al. 2018

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Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immunosuppressive cells of the myeloid lineage upregulated by mediators of inflammation, such as IL-2, granulocyte colony-stimulating factor, and S100A8/A9. These cells have been studied extensively by tumor biologists. Because of their robust immunosuppressive potential, MDSCs have stirred recent interest among transplant immunologists as well. MDSCs inhibit T-cell responses through, among other mechanisms, the activity of arginase-1 and inducible nitric oxide synthase, and the expansion of T regulatory cells. In the context of transplantation, MDSCs have been studied in several animal models, and to a lesser degree in humans. Here, we will review the immunosuppressive qualities of this important cell type and discuss the relevant studies of MDSCs in transplantation. It may be possible to exploit the immunosuppressive capacity of MDSCs for the benefit of transplant patients.

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