Innate antiviral defenses in body fluids and tissues

Baron, Samuel; Singh, I. S.; Chopra, Ashok K.; Coppenhaver, Dorian H.; Pan, Jingzhi

doi:10.1016/s0166-3542(00)00126-1

Cited by 23 publications

(16 citation statements)

References 112 publications

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“…An estimated 90% to 95% of all infections are initiated at mucosal surfaces, which form an interface with the outside world. These surfaces are covered and protected by the secretions of various exocrine glands, including the lacrimal glands (3,4), the salivary glands (4 -7), and the glands of the respiratory (6, 8 -11) and gastrointestinal tract (4,6,(12)(13)(14). The antimicrobial proteins (eg, mucins, cystatins, histatins, and lactoferrin) secreted by these glands constitute a first line of defense, preventing infection and disease by interfering with microbial entry and multiplication (3, 4, 6 -8, 11-15).…”

Section: Introductionmentioning

confidence: 99%

Innate Secretory Immunity in Response to Laboratory Stressors That Evoke Distinct Patterns of Cardiac Autonomic Activity

Bosch

Geus

Veerman

et al. 2003

Psychosomatic Medicine

210

169

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Objective: Most infections begin at mucosal surfaces. These surfaces are covered by the secretory proteins of the exocrine glands (eg, the salivary, respiratory, and gastrointestinal glands), which provide a first line of innate defense. The release of these secretory proteins is under neuroendocrine control and thus, in theory, sensitive to modulation by psychosocial stress. This was empirically tested by measuring the salivary secretion of cystatin S, lactoferrin, ␣-amylase, the mucins MUC5B and MUC7, and total salivary protein in response to stressors known to evoke distinct patterns of cardiac autonomic activity. Methods: Thirty-two undergraduate volunteers were each subjected to two laboratory stressors and a control condition. Stressors were an active coping memory test and a passive coping video presentation showing surgical procedures. In the control condition participants viewed a didactic video presentation. Results: The stressors evoked the expected distinct patterns of cardiac autonomic activity. The memory test produced a strong increase in sympathetic activity (evidenced by a shortened preejection period), and a decrease in cardiac parasympathetic activity (evidenced by a decrease in heart rate variability). This active coping response was associated with an enhanced secretion ( g/min, controlling for salivary flow rate) of MUC7, lactoferrin, ␣-amylase, and total salivary protein. Conversely, the surgical video produced an increase in cardiac vagal tone and a modest increase in sympathetic activity. This passive coping response was associated with an enhanced secretion of all proteins studied. These secretory responses were generally larger than the secretory responses during the active coping memory test. Correlation analyses indicated that for both stressors autonomic and cardiovascular reactivity was positively associated with an enhanced and prolonged secretory activity. Conclusions: Stress-induced modulation of innate secretory immunity may be a contributing factor in the observed relationship between stress and susceptibility to infectious diseases. We further propose a more differentiated approach to acute stress by distinguishing among stressors with distinct autonomic nervous system effects.

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Section: Introductionmentioning

confidence: 99%

Innate Secretory Immunity in Response to Laboratory Stressors That Evoke Distinct Patterns of Cardiac Autonomic Activity

Bosch

Geus

Veerman

et al. 2003

Psychosomatic Medicine

210

169

View full text Add to dashboard Cite

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“…In the absence of an effective vaccine for RSV, alternative prophylactic or treatment options are being actively pursued (e.g., polyclonal antibodies, monoclonal antibodies, antisense nucleotides, and viral inhibitors) (36). Interferons (IFNs) are a heterogeneous family of cytokines with demonstrated antiviral, antitumor, and immunomodulatory activities (3,35). Local production of IFN-␣/␤ plays an important defensive role in many respiratory virus infections by limiting viral replication until virus-specific host defense mechanisms develop (4).…”

mentioning

confidence: 99%

Activity and Regulation of Alpha Interferon in Respiratory Syncytial Virus and Human Metapneumovirus Experimental Infections

Guerrero-Plata¹,

Baron

Poast

et al. 2005

J Virol

Self Cite

112

142

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Respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) cause a similar spectrum of respiratory infections in humans. Classified within the Paramyxoviridae family, Pneumovirinae subfamily, RSV and hMPV present a significant degree of divergence in genome constellation, organization, and protein sequences. RSV has been reported to be a poor inducer of alpha/beta interferons (IFN-␣/␤) and partially resistant to its antiviral activity. The nature of the innate immune response to hMPV is currently unknown. Herein, an experimental mouse model was used to investigate the interplay between RSV and hMPV infections and IFN-␣ in the airways. RSV-infected BALB/c mice treated intranasally with either poly-ICLC, a potent inducer of IFN-␣, or directly with recombinant IFN-␣ showed significantly reduced lung viral titers, inflammation, and clinical disease than untreated controls. However, RSV was significantly less sensitive to the antiviral activity of IFN-␣ than hMPV. Similarly, when the ability to directly induce IFN-␣ production was assessed, RSV was clearly a weaker inducer of IFN-␣ than hMPV, as shown by both kinetics and the absolute amount of IFN-␣ secreted into the bronchoalveolar lavage. To further investigate the putative inhibitory effect of these viruses on IFN-␣ production, mice were infected for 48 h prior to treatment with poly-ICLC or a specific Toll-like receptor 9 ligand, CpG oligodeoxynucleotides. Strikingly, both poly-ICLC-and CpG-mediated IFN-␣ production was abrogated by either RSV or MPV infection. These results suggest that a complex interplay between virus-specific and host-mediated responses regulates IFN-␣ in the lung during infection by members of the Pneumovirinae family.

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“…

Crustins are proteins in the plasma or hemocyte granules of crustaceans [1][2][3]. The main function of crustins are unknown but they contain a motif with known or putative proteinase inhibitors of the WAP family [4,5].

…”

mentioning

confidence: 99%

cDNA sequence encoding an 11.5-kDa antibacterial peptide of the shrimp Penaeus monodon

Chen

Pan

Kuo

2004

Fish & Shellfish Immunology

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Innate antiviral defenses in body fluids and tissues

Cited by 23 publications

References 112 publications

Innate Secretory Immunity in Response to Laboratory Stressors That Evoke Distinct Patterns of Cardiac Autonomic Activity

Innate Secretory Immunity in Response to Laboratory Stressors That Evoke Distinct Patterns of Cardiac Autonomic Activity

Activity and Regulation of Alpha Interferon in Respiratory Syncytial Virus and Human Metapneumovirus Experimental Infections

cDNA sequence encoding an 11.5-kDa antibacterial peptide of the shrimp Penaeus monodon

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