Injection of human mesenchymal stem cells improves healing of vocal folds after scar excision—A xenograft analysis

Abstract

Human mesenchymal stem cells injected into the rabbit VF following the excision of a chronic scar, were found to enhance the functional healing of the VF with reduced lamina propria thickness and restored viscoelastic shear properties.

An investigation of left–right vocal fold symmetry in rheological and histological properties

“…Elastic shear modulus G ' and dynamic viscosity η ' of the left and right rabbit vocal folds were plotted in Figure and Figure , respectively. Our rabbit rheological data were in good agreement with those reported in several previous studies …”

“…Our rabbit rheological data were in good agreement with those reported in several previous studies. 13,[25][26][27]…”

Diagnostic and therapeutic pitfalls in benign vocal fold diseases

“…Depending on its extent, different techniques can be used to ameliorate the situation. Local undermining procedures that remove the scar tissue from underneath are recommended as well as injections of various substances such as corticosteroids [109] or biocompatible materials [135], [136], [137], [138], [139], [140], [141]. Newer substances such as mesenchymal stem cells and growth factors [141], [142] can also be injected.…”

Cell-cell interaction between vocal fold fibroblasts and bone marrow mesenchymal stromal cells in three-dimensional hyaluronan hydrogel

“…Since 1995, bone marrow‐derived MSCs (BM‐MSCs) have been used in Phase I/II clinical trials in other parts of the body to treat scarring and tissue deficits (Langston, ; Mazo et al ., ). Moreover, attention has been directed at the potential of BM‐MSCs therapy for the prevention and treatment of vocal fold scar (Hong et al ., ; Svensson et al ., ). To date there is a paucity of data defining interactions between BM‐MSCs and native tissue cells, specifically in a biomaterial environment.…”