Injection moulding of micropillar arrays: a comparison of poly(methyl methacrylate) and cyclic olefin copolymer

Guan, Bin; Pai, Jing-Hong; Cherrill, Mark; Michalatos, Billy; Priest, Craig

doi:10.1007/s00542-022-05350-4

Cited by 6 publications

(3 citation statements)

References 52 publications

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“…Second, each component of the platform can potentially be miniaturized and integrated for POC applications. For instance, the microfluidic pillar array can be mass-produced by using thermoplastics via injection molding . The optical system with bulky instrumentation can be simplified by using compact laser diodes as the light source and intensity-based photodetectors for low-cost read-outs .…”

Section: Resultsmentioning

confidence: 99%

Microsphere-Enabled Micropillar Array for Whispering Gallery Mode Virus Detection

Guan,

Kok,

Riesen

et al. 2024

ACS Appl. Mater. Interfaces

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Rapid detection of pathogens and analytes at the point of care offers an opportunity for prompt patient management and public health control. This paper reports an open microfluidic platform coupled with active whispering gallery mode (WGM) microsphere resonators for the rapid detection of influenza viruses. The WGM microsphere resonators, precoated with influenza A polyclonal antibodies, are mechanically trapped in the open micropillar array, where the evaporation-driven flow continuously transports a small volume (∼μL) of sample to the resonators without auxiliaries. Selective chemical modification of the pillar array changes surface wettability and flow pattern, which enhances the detection sensitivity of the WGM resonatorbased virus sensor. The optofluidic sensing platform is able to specifically detect influenza A viruses within 15 min using a few microliters of sample and displays a linear response to different virus concentrations.

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Section: Resultsmentioning

confidence: 99%

Microsphere-Enabled Micropillar Array for Whispering Gallery Mode Virus Detection

Guan,

Kok,

Riesen

et al. 2024

ACS Appl. Mater. Interfaces

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“…In the case of PP molded parts, which yielded the highest replication for the different textures, Insert C demonstrated a 39% increase when turned, while Insert D demonstrated a 53% increase. The PMMA samples showed a similar growth trend, but not as significant, due to the lack of molecular movements when molded at 80 • C. The flow was less inhibited when the parallel trench microstructures were parallel to the flow direction [45].…”

Section: Replication Of Feature Heightmentioning

confidence: 87%

Wetting Characteristics of Laser-Ablated Hierarchical Textures Replicated by Micro Injection Molding

et al. 2023

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Texturing can be used to functionalize the surface of plastic parts and, in particular, to modify the interaction with fluids. Wetting functionalization can be used for microfluidics, medical devices, scaffolds, and more. In this research, hierarchical textures were generated on steel mold inserts using femtosecond laser ablation to transfer on plastic parts surface via injection molding. Different textures were designed to study the effects of various hierarchical geometries on the wetting behavior. The textures are designed to create wetting functionalization while avoiding high aspect ratio features, which are complex to replicate and difficult to manufacture at scale. Nano-scale ripples were generated over the micro-scale texture by creating laser-induced periodic surface structures. The textured molds were then replicated by micro-injection molding using polypropylene and poly(methyl methacrylate). The static wetting behavior was investigated on steel inserts and molded parts and compared to the theoretical values obtained from the Cassie–Baxter and Wenzel models. The experimental results showed correlations between texture design, injection molding replication, and wetting properties. The wetting behavior on the polypropylene parts followed the Cassie–Baxter model, while for PMMA, a composite wetting state of Cassie–Baxter and Wenzel was observed.

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“…11 The warping and shrinkage distortion of the molded part could be effectively avoided by selecting right parameters. 12,13 By analyzing the molding quality of polymethyl methacrylate (PMMA) and cyclic olefin copolymer (COC) micropillar arrays under different parameters, Priest et al 14 analyzed the molding quality of PMMA and COC micropillar arrays under varying parameters, discovering that the lower surface energy of COC facilitated easier demolding without microstructural fractures. Fan et al 15 showed that in addition to mold design, injection pressure, injection speed, and melt temperature needed to be carefully adjusted to meet the requirements.…”

Section: Introductionmentioning

confidence: 99%

Enhancing structural replication of microfluidic chips: Parameter optimization and mold insert modification

Wang,

Weng,

Fei

et al. 2024

Polymer Engineering & Sci

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The demolding process in micro‐injection molding constitutes a critical phase, exerting a decisive influence on the quality of polymer microstructures. In this study, the demolding forces of PMMA microfluidic chips were measured under different demolding temperatures, packing pressures, and demolding speeds by using pure nickel (Ni) mold insert. The dimensional deviations of the microchannels with different aspect ratios were analyzed. In addition, the effect of mold insert modification on the demolding force was further analyzed. The results showed that the effect of demolding temperature on the demolding force was the most significant, and the peak demolding force decreased with the decrease in temperature. The width of the microchannels increased and the depth decreased after demolding, while the opposite results were observed for the micro‐mixing structures. However, the dimensional deviation of the micro‐mixing structures was larger than that of the microchannels. Using the optimal molding parameters, the peak demolding force could be reduced from 114.0 N at 110°C to 47.0 N, a decrease of 58.8%. It is noteworthy that, when the microchannel was narrower than 100 μm, achieving precise replication of microchannel dimensions became progressively more challenging as the microchannel width decreased. Using the Ni‐WS2 mold insert with low surface energy and low friction coefficient, the demolding force could be further reduced by 38.3%. The effect of the molding quality of microfluidic chip microstructures on the mixing performance of heavy metals was demonstrated by micro‐mixing experiments.Highlights Demolding temperature crucially affects microstructure dimensions. Optimal parameters and modified mold insert reduce demolding force by 38.3%. Dimensional deviation increases with the increase of microchannel aspect ratio. Optimized microfluidic chip enhances Co2+ chemiluminescence by 6.42%.

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Injection moulding of micropillar arrays: a comparison of poly(methyl methacrylate) and cyclic olefin copolymer

Cited by 6 publications

References 52 publications

Microsphere-Enabled Micropillar Array for Whispering Gallery Mode Virus Detection

Microsphere-Enabled Micropillar Array for Whispering Gallery Mode Virus Detection

Wetting Characteristics of Laser-Ablated Hierarchical Textures Replicated by Micro Injection Molding

Enhancing structural replication of microfluidic chips: Parameter optimization and mold insert modification

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