Injecting autologous platelet rich plasma solely into the knee joint is not adequate in treating geriatric patients with moderate to severe knee osteoarthritis

Chen, Carl P.C.; Chen, Jean-Lon; Hsu, Chih‐Chin; Pei, Yu‐Cheng; Chang, Wei-Han; Lu, Hsueh-Chih

doi:10.1016/j.exger.2019.01.018

Cited by 14 publications

(17 citation statements)

References 22 publications

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“…By the same token, it was suggested that intra-articular PRP injections associated with pes anserinus PRP injections should be a treatment option for elderly patients with knee OA induced positive proteomic changes in the synovial fluid along with functional improvement [ 59 ].…”

Section: Human Clinical Trialsmentioning

confidence: 99%

The Effect of Platelet-Rich Plasma on the Intra-Articular Microenvironment in Knee Osteoarthritis

Szwedowski

Szczepanek

Paczesny³

et al. 2021

IJMS

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Knee osteoarthritis (KOA) represents a clinical challenge due to poor potential for spontaneous healing of cartilage lesions. Several treatment options are available for KOA, including oral nonsteroidal anti-inflammatory drugs, physical therapy, braces, activity modification, and finally operative treatment. Intra-articular (IA) injections are usually used when the non-operative treatment is not effective, and when the surgery is not yet indicated. More and more studies suggesting that IA injections are as or even more efficient and safe than NSAIDs. Recently, research to improve intra-articular homeostasis has focused on biologic adjuncts, such as platelet-rich plasma (PRP). The catabolic and inflammatory intra-articular processes that exists in knee osteoarthritis (KOA) may be influenced by the administration of PRP and its derivatives. PRP can induce a regenerative response and lead to the improvement of metabolic functions of damaged structures. However, the positive effect on chondrogenesis and proliferation of mesenchymal stem cells (MSC) is still highly controversial. Recommendations from in vitro and animal research often lead to different clinical outcomes because it is difficult to translate non-clinical study outcomes and methodology recommendations to human clinical treatment protocols. In recent years, significant progress has been made in understanding the mechanism of PRP action. In this review, we will discuss mechanisms related to inflammation and chondrogenesis in cartilage repair and regenerative processes after PRP administration in in vitro and animal studies. Furthermore, we review clinical trials of PRP efficiency in changing the OA biomarkers in knee joint.

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Section: Human Clinical Trialsmentioning

confidence: 99%

The Effect of Platelet-Rich Plasma on the Intra-Articular Microenvironment in Knee Osteoarthritis

Szwedowski

Szczepanek

Paczesny³

et al. 2021

IJMS

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“…A significant improvement of pain and functional scores, as well as decreases of the inflammatory response, were also obtained by the concomitant injection of PRP both intra-articular and in peri-meniscal soft tissue structures, thus widening the PRP effect on pes anserine tendons, bursa, medial collateral ligament and medial meniscus [176].…”

Section: Knee Osteoarthritismentioning

confidence: 83%

Platelet Concentrates in Musculoskeletal Medicine

Mariani

Pulsatelli

2020

IJMS

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Platelet concentrates (PCs), mostly represented by platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) are autologous biological blood-derived products that may combine plasma/platelet-derived bioactive components, together with fibrin-forming protein able to create a natural three-dimensional scaffold. These types of products are safely used in clinical applications due to the autologous-derived source and the minimally invasive application procedure. In this narrative review, we focus on three main topics concerning the use of platelet concentrate for treating musculoskeletal conditions: (a) the different procedures to prepare PCs, (b) the composition of PCs that is related to the type of methodological procedure adopted and (c) the clinical application in musculoskeletal medicine, efficacy and main limits of the different studies.

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“…Inclusion of intra-osseous injections leads to improvements in the subscales of WOMAC and self-reported pain [69]. A study with 30 geriatric patients with moderate to severe osteoarthritis [70] indicated that simultaneous intra-articular and perimeniscal pes anserinus PRP injections can provide favorable proteomic changes and better functional and pain scores. With this method, PRP can be brought in contact with pes anserine tendons, bursa, medial collateral ligament, and medial meniscus [70].…”

Section: Latest Outcomes: Prp For Knee Osteoarthritismentioning

confidence: 99%

“…A study with 30 geriatric patients with moderate to severe osteoarthritis [70] indicated that simultaneous intra-articular and perimeniscal pes anserinus PRP injections can provide favorable proteomic changes and better functional and pain scores. With this method, PRP can be brought in contact with pes anserine tendons, bursa, medial collateral ligament, and medial meniscus [70]. The study recommends the multiple monthly, at least two monthly injections.…”

Section: Latest Outcomes: Prp For Knee Osteoarthritismentioning

confidence: 99%

The Clinical Use of Biologics in the Knee Lesions: Does the Patient Benefit?

Cengiz

Pereira

Espregueira-Mendes

et al. 2019

Curr Rev Musculoskelet Med

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Purpose of Review Overview the outcomes of the latest use of platelet-rich plasma (PRP) for the treatment of knee lesions in the clinics and discuss the challenges and limitations. Recent Findings Recent clinical studies mainly indicate there may be benefit of PRP usage for the treatment of knee lesions. As an autologous source of bioactive components, PRP has been shown to be typically safe, free of major adverse outcomes. The use of PRP has been continuously increasing, and some well-designed, double-blinded, placebo-controlled clinical trials have been published. Summary Clinical outcomes relating to PRP usage are multifactorial and depend on the severity of the lesion and patient characteristics. Although PRP is safe to use and it can be easily applied in the clinics, case-specific considerations are needed to determine whether PRP could be beneficial or not. If the use of PRP is favored, then, the configuration/optimization of the preparation and administration/delivery strategy with or without a concomitant treatment may further enhance the clinical outcomes and patients' experience.

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Injecting autologous platelet rich plasma solely into the knee joint is not adequate in treating geriatric patients with moderate to severe knee osteoarthritis

Cited by 14 publications

References 22 publications

The Effect of Platelet-Rich Plasma on the Intra-Articular Microenvironment in Knee Osteoarthritis

The Effect of Platelet-Rich Plasma on the Intra-Articular Microenvironment in Knee Osteoarthritis

Platelet Concentrates in Musculoskeletal Medicine

The Clinical Use of Biologics in the Knee Lesions: Does the Patient Benefit?

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