Injectable Platelet Rich Fibrin (i-PRF): A Gem in Dentistry

Agrawal, Diksha; Jaiswal, Priyanka

doi:10.31782/ijcrr.2020.122116

Cited by 19 publications

(26 citation statements)

References 16 publications

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“…According to the preparation of Mourao et al, 9 mL of autologous blood was collected without taking any extra preservatives in a test tube and then centrifuged at 3300 rpm force for two minutes, yielding an orange-colored fluid in the i-PRF tube [19,20]. As stated by Miron et al, autologous blood was collected without any anticoagulants or preservatives into plastic tubes and centrifuged at a force of 700 rpm for three minutes.…”

Section: Preparation Of I-prfmentioning

confidence: 99%

“…The upper layer contains separated plasma and platelets, which are pale yellow or orange and are used in an injectable form [19]. According to Al-Maawi et al, blood was collected in the tube and centrifuged at 600 rpm for eight minutes [20]. After centrifugation, i-PRF was generated, with yellow orange-colored blood [19].…”

Section: Preparation Of I-prfmentioning

confidence: 99%

“…It has been found that i-PRF can promote an increased rate of migration of fibroblast and the expression of the growth factors of PDGF, TGF, and collagen1 as well as release higher quantities of several growth factors [20].…”

Section: Growth Factorsmentioning

confidence: 99%

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Third-Generation Platelet Concentrates in Periodontal Regeneration: Gaining Ground in the Field of Regeneration

Shirbhate¹,

Bajaj²

2022

Cureus

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Platelets are important for hemostasis and the healing of wounds. In clinical settings, healing cytokines including insulin-like growth factors (IGF), platelet-derived growth factors (PDGF), and transforming growth factors (TGF) are commonly implemented. The regenerative approach in dentistry frequently employs platelet concentrates (PCs) that are "autologous in origin" and have a high concentration of platelets, growth factors, and leukocytes. First-generation PCs is made of platelet-rich plasma (PRP), while secondgeneration PC is made of platelet-rich fibrin (PRF). Both have limitations, so modification protocols and development in PRP and PRF derivatives are required for advancement mechanisms, strength, biodegradability, retention ability in the field of regenerative dentistry, and so on. As third-generation PC, newer genera kinds of PRF, such as advanced-PRF (A-PRF), advanced-PRF+ (A-PRF+), injectable-PRF (i-PRF), and titanium-PRF (T-PRF), were introduced. A-PRF matrices in their solid form were introduced using the low-speed centrifugation concept (LSCC). The applied relative centrifugal force (RCF) for A-PRF is reduced to 208 g as a result of this improved preparation process. A-PRF features a greater number of neutrophil granules in the distal region, especially at the red blood cells-buffer coat (RBC-BC) interface, and the A-PRF clot has a more porosity-like structure with a bigger interfibrous space than PRF. Since the PRF is in a gel form and is difficult to inject, i-PRF was formulated to address this problem. Compared to the other two protocols, the i-PRF protocol requires far less time, and this is the advantage of this PC. This is because i-PRF just needs the blood components to be separated, which happens within the first two to four minutes. Compared to normal L-PRF, T-PRF creates fibrin that is thicker and more densely woven. Titanium has a higher hemocompatibility than glass, which could lead to greater polymerized fibrin formation. In periodontal regenerative operations, oral surgery, and implant dentistry, PRF and its newer advanced modifications have demonstrated promising results and desirable results in both soft and hard tissue regenerative techniques.

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Section: Preparation Of I-prfmentioning

confidence: 99%

Section: Preparation Of I-prfmentioning

confidence: 99%

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Third-Generation Platelet Concentrates in Periodontal Regeneration: Gaining Ground in the Field of Regeneration

Shirbhate¹,

Bajaj²

2022

Cureus

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“…It played a role in carrying cells for the purpose of tissue regeneration, treatment of various types of periodontal defects, gingival recessions, palatal wound closure, and wound healing [ 13 ]. PRF is obtained in a gel form which sometimes limits its clinical application when there is the necessity for a liquid form conducive to being injected [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Hyaluronic Acid Versus the Injectable Platelet-Rich Fibrin in the Management of the Thin Gingival Phenotype: A Split-Mouth Randomized Controlled Clinical Trial

Faour¹,

Dayoub²,

Hajeer³

2022

Cureus

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Background Several procedures have been used to enhance thin gingival phenotype and the majority of these procedures have been surgical. A new minimally invasive approach that involved multiple injections of platelet-rich fibrin (i-PRF) to enhance the thin gingival phenotype has been proposed. As the hyaluronic acid (HA) and the i-PRF share similar properties in terms of promoting periodontal regeneration, the present trial aimed to evaluate the effectiveness of multiple injections of the i-PRF in patients with thin gingival phenotypes in comparison with those of the HA in increasing the gingival thickness (GT) and the keratinized tissue width (KTW). Materials and methods Eighty-four sites from 14 systematically healthy patients who had thin gingival phenotypes (GT ≤1 mm) were included in this split-mouth randomized controlled trial. For each patient, each side of the anterior mandible was randomly allocated to one of the two materials (HA or i-PRF). In the HA group, the selected sites of the gingiva were injected with cross-linked HA using a 30-gauge microneedle. In the i-PRF group, the i-PRF was injected in the same manner. This procedure was repeated in both groups three times with intervals of 7 days. The GT, KTW, and periodontal indices: gingival index (GI), bleeding on probing (BOP), and probing depth (PD) were measured at baseline, 1 month, and 3 months following the initial injection. Results The GT increased significantly in both groups at the three assessment times (p<0.001). The KTW also showed a statistically significant increase in the intragroup comparisons in both groups (p<0.05). No statistically significant difference was observed between the two groups at the three assessment times for the GT and the KTW (p>0.05). The GI significantly decreased after 1 month and 3 months compared to the baseline values in both groups (p<0.05). The intergroup comparisons for the GI revealed no statistically significant differences at the three assessment times (p>0.05). As for the BOP and the PD, no statistically significant differences were found between the three assessment times (p>0.05) and between the two groups at each assessment time (p>0.05). Conclusion Multiple injections of the i-PRF and the HA in the thin gingival phenotype resulted in an increased GT and increased KTW, with no statistically significant differences between the two methods. Both minimally invasive techniques were more effective in improving the GT rather than the KTW.

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“…The benefits of i-PRF show slow and sustained release of growth factors, by releasing the expression of transforming growth factor-β and collagen-1 mRNA along with cells migration. (35) It has advancement through injecting patients autologous PRF in indicated areas of bone, soft tissue, or skin. (36,37) In our animal study, the histomorphometric evaluation of the amount of the newly regenerated bone showed that adding PRGF and PRF as bone graft materials to bone cavities caused a significant increase in bone regeneration at 2 and 4 weeks in comparison to control groups without bone graft material.…”

Section: Discussionmentioning

confidence: 99%

Impact of Different Platelet Concentrates Application on Bone Regeneration. An Experimental Study

Elkabbany

Abdelsameaa

Mohamed

2021

Egyptian Dental Journal

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Purpose: This experimental study was to evaluate and compare bone regeneration capacity of experimental bone defects filled with different autologous platelet concentrates (APCs) as a bone graft material in the rabbit's tibiae. Material and methods:A total of forty-two adult rabbits were included in this study. After creation of bone defects, the animals were randomly assigned to three groups. In control group, no bone graft was used (Group A, n=14), in one test group Plasma Rich in Growth Factors (PRGF) was used as bone graft material (Group B, n=14), and in the other test group Injectable Platelet Rich Fibrin (i-PRF) was used as bone graft material (Group C, n=14). After implantation, each group was further divided into two subgroups, where rabbits were sacrificed 2 and 4 weeks postoperatively and the defects were evaluated with histologic and histomorphometric analysis.Results: Both test groups (Group B and Group C) treated with APCs (PRGF: 10.92±0.85 & 41.53±2.55and i-PRF: 13.13±0.68 &57.27±1.66 at 2 and 4 weeks respectively) demonstrated higher percentages of new bone formation than the control group (5.11±1.15 & 30.31±1.29 at 2 and 4 weeks respectively) (P < 0.001). Significant difference was found between the two test groups and control group (P < 0.001). On the other hand, significant difference was found between test groups (P < 0.001).Conclusions: Within the limitation of this animal study, the adjunct implication of either i-PRF or PRGF in endodontic surgery may be of great significance as it dramatically improves bone regeneration.

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Injectable Platelet Rich Fibrin (i-PRF): A Gem in Dentistry

Cited by 19 publications

References 16 publications

Third-Generation Platelet Concentrates in Periodontal Regeneration: Gaining Ground in the Field of Regeneration

Third-Generation Platelet Concentrates in Periodontal Regeneration: Gaining Ground in the Field of Regeneration

Evaluation of the Hyaluronic Acid Versus the Injectable Platelet-Rich Fibrin in the Management of the Thin Gingival Phenotype: A Split-Mouth Randomized Controlled Clinical Trial

Impact of Different Platelet Concentrates Application on Bone Regeneration. An Experimental Study

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