Injectable gel: Poly(ethylene glycol)–sebacic acid polyester

Lee, Jisun; Joo, Min Kyung; Oh, Hejin; Sohn, Youn Soo; Jeong, Byeongmoon

doi:10.1016/j.polymer.2006.03.109

Cited by 41 publications

(27 citation statements)

References 24 publications

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“…[37] In addition, multiblock copolymers of PEG-sebacate (PEG-SA) were synthesized by simple condensation polymerization. [38] A soft gel formed when a 25 wt.-% aqueous solution of the PEG-SA multiblock was heated to 37 8C, and gel integrity persisted for more than three weeks in phosphate buffer, pH 7.4, at 37 8C. In addition, it was found that a stereocomplex of the enantiomeric triblock copolymers (10 wt.-%), PLLA-PEG-PLLA (1 300-4 600-1 300), and poly(D-lactide)-PEG-poly-(D-lactide) (PDLA-PEG-PDLA) (1 100-4 600-1 100), in water could induce temperature-dependent gelation, although the individual enantiomeric copolymers did not show thermal gelation.…”

Section: Poly(ethylene Glycol) (Peg)/polyestermentioning

confidence: 99%

Injectable Biodegradable Hydrogels

Nguyen

Lee

2010

Macromolecular Bioscience

416

343

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Injectable biodegradable copolymer hydrogels, which exhibit a sol–gel phase transition in response to external stimuli, such as temperature changes or both pH and temperature (pH/temperature) alterations, have found a number of uses in biomedical and pharmaceutical applications, such as drug delivery, cell growth, and tissue engineering. These hydrogels can be used in simple pharmaceutical formulations that can be prepared by mixing the hydrogel with drugs, proteins, or cells. Such formulations are administered in a straightforward manner, through site‐specific control of release behavior, and the hydrogels are compatible with biological systems. This review will provide a summary of recent progress in biodegradable temperature‐sensitive polymers including polyesters, polyphosphazenes, polypeptides, and chitosan, and pH/temperature‐sensitive polymers such as sulfamethazine‐, poly(β‐amino ester)‐, poly(amino urethane)‐, and poly(amidoamine)‐based polymers. The advantages of pH/temperature‐sensitive polymers over simple temperature‐sensitive polymers are also discussed. A perspective on the future of injectable biodegradable hydrogels is offered.magnified image

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Section: Poly(ethylene Glycol) (Peg)/polyestermentioning

confidence: 99%

Injectable Biodegradable Hydrogels

Nguyen

Lee

2010

Macromolecular Bioscience

416

343

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“…The drug-loading and in vitro release experiments were preformed in a method similar to that described elsewhere [22][23][24]. Ofloxacin was added to microgel dispersion at 0.1 mg/ml concentrations to evaluate the release rate of the model drugs in vitro.…”

Section: Characterizationmentioning

confidence: 99%

Thermosensitive phase behavior and drug release of in situ N-isopropylacrylamide copolymer

Chen

Zhong

et al. 2012

Materials Science and Engineering: C

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“…A thermoreversible gel system essentially consists of a thermogelling polymer, the aqueous solution of which is a liquid at or below room temperature, and forms a gel at body temperature (∼37°C) (21). Such systems have been suggested for the delivery of cells or biopharmaceuticals that are susceptible to heat or organic solvents (21). Thermally induced gelling systems show thermoreversible sol/gel transitions and are characterized by a lower critical solution temperature (22)(23)(24)(25).…”

Section: Introductionmentioning

confidence: 99%

Nanostructured Cubosomes in a Thermoresponsive Depot System: An Alternative Approach for the Controlled Delivery of Docetaxel

et al. 2015

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Abstract. The aim of the present study was to develop and evaluate a thermoresponsive depot system comprising of docetaxel-loaded cubosomes. The cubosomes were dispersed within a thermoreversible gelling system for controlled drug delivery. The cubosome dispersion was prepared by dilution method, followed by homogenization using glyceryl monooleate, ethanol and Pluronic ® F127 in distilled water. The cubosome dispersion was then incorporated into a gelling system prepared with Pluronic ® F127 and Pluronic ® F68 in various ratios to formulate a thermoresponsive depot system. The thermoresponsive depot formulations undergo a thermoreversible gelation process i.e., they exists as free flowing liquids at room temperature, and transforms into gels at higher temperatures e.g., body temperature, to form a stable depot in aqueous environment. The mean particle size of the cubosomes in the dispersion prepared with Pluronic ® F127, with and without the drug was found to be 170 and 280 nm, respectively. The prepared thermoresponsive depot system was evaluated by assessing various parameters like time for gelation, injectability, gel erosion, and in-vitro drug release. The drug-release studies of the cubosome dispersion before incorporation into the gelling system revealed that a majority (∼97%) of the drug was released within 12 h. This formulation also showed a short lag time (∼3 min). However, when incorporated into a thermoresponsive depot system, the formulation exhibited an initial burst release of ∼21%, and released only ∼39% drug over a period of 12 h, thus indicating its potential as a controlled drug delivery system.

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Injectable gel: Poly(ethylene glycol)–sebacic acid polyester

Cited by 41 publications

References 24 publications

Injectable Biodegradable Hydrogels

Injectable Biodegradable Hydrogels

Thermosensitive phase behavior and drug release of in situ N-isopropylacrylamide copolymer

Nanostructured Cubosomes in a Thermoresponsive Depot System: An Alternative Approach for the Controlled Delivery of Docetaxel

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