Injectable degradable PVA microgels prepared by microfluidic technology for controlled osteogenic differentiation of mesenchymal stem cells

Hou, Yong; Xie, Wenyan; Achazi, Katharina; Cuellar-Camacho, José Luis; Melzig, Matthias F.; Chen, Wei; Haag, Rainer

doi:10.1016/j.actbio.2018.07.003

Cited by 90 publications

(80 citation statements)

References 58 publications

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“…The effect of different pore entrance angles can be seen as a link to the ‘membranes of the future’ that may have uniform pores, of which the actual geometry can be used to tune separation characteristics. Other example of areas that can benefit from our results are chromatography, injectable microgels for tissue engineering 26 and studies on blood cell flow 27 .…”

Section: Discussionmentioning

confidence: 97%

Conformational changes influence clogging behavior of micrometer-sized microgels in idealized multiple constrictions

Meireles

Bouchoux

Schroën

2019

Sci Rep

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Clogging of porous media by soft particles has become a subject of extensive research in the last years and the understanding of the clogging mechanisms is of great importance for process optimization. The rise in the utilization of microfluidic devices brought the possibility to simulate membrane filtration and perform in situ observations of the pore clogging mechanisms with the aid of high speed cameras. In this work, we use microfluidic devices composed by an array of parallel channels to observe the clogging behavior of micrometer sized microgels. It is important to note that the microgels are larger than the pores/constrictions. We quantify the clog propensity in relation to the clogging position and particle size and find that the majority of the microgels clog at the first constriction independently of particle size and constriction entrance angle. We also quantify the variations in shape and volume (2D projection) of the microgels in relation to particle size and constriction entrance angle. We find that the degree of deformation increases with particle size and is dependent of constriction entrance angle, whereas, changes in volume do not depend on entrance angle.

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Section: Discussionmentioning

confidence: 97%

Conformational changes influence clogging behavior of micrometer-sized microgels in idealized multiple constrictions

Meireles

Bouchoux

Schroën

2019

Sci Rep

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“…In addition to the high surface area that is important to transfer nutrients, microgels can escape phagocytosis so they can remain in the injury site. Hou et al [ 76 ] developed degradable PVA microgels for osteogenic bone mesenchymal stem cells and growth factor encapsulation. The biomaterial was produced by using a microfluidic flow-focusing device and presented suitable elasticity, degradation, and bioactivity.…”

Section: Microgelsmentioning

confidence: 99%

“…The authors observed that the low rate of crosslinking with the biocompatible polymers was crucial to ensure prolonged survival, proliferation, and migration of the cells. Additionally, the slow release of the growth factor by PVA reinforced osteogenic differentiation in vitro, highlighting the great potential of the microgel for application in regenerative medicine [ 76 ].…”

Section: Microgelsmentioning

confidence: 99%

An Updated Review of Macro, Micro, and Nanostructured Hydrogels for Biomedical and Pharmaceutical Applications

et al. 2020

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Hydrogels are materials with wide applications in several fields, including the biomedical and pharmaceutical industries. Their properties such as the capacity of absorbing great amounts of aqueous solutions without losing shape and mechanical properties, as well as loading drugs of different nature, including hydrophobic ones and biomolecules, give an idea of their versatility and promising demand. As they have been explored in a great number of studies for years, many routes of synthesis have been developed, especially for chemical/permanent hydrogels. In the same way, stimuli-responsive hydrogels, also known as intelligent materials, have been explored too, enhancing the regulation of properties such as targeting and drug release. By controlling the particle size, hydrogel on the micro- and nanoscale have been studied likewise and have increased, even more, the possibilities for applications of the so-called XXI century materials. In this paper, we aimed to produce an overview of the recent studies concerning methods of synthesis, biomedical, and pharmaceutical applications of macro-, micro, and nanogels.

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“…Poly(vinyl alcohol) (PVA), due to its biocompatibility, has numerous biomedical applications, including wound dressing, 22,23 contact lenses, 24 and implants for various tissues and organs such as cartilage, 25 vascular access, 26 stent for biliary drainage, 21 ligament, 27 and tissue engineering applications. 28 The fabrication of PVA hydrogels with anisotropic structures using electrospinning has been investigated due to its small ber diameter, high surface-to-volume ratio, and controllable porous structure and shape. However, the hydrophilicity of PVA nanobers destabilizes the aqueous solution and subsequently decreases their mechanical properties, thereby limiting their suitability for biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of tough, anisotropic, chemical-crosslinker-free poly(vinyl alcohol) nanofibrous cryogels via electrospinning

et al. 2020

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Injectable degradable PVA microgels prepared by microfluidic technology for controlled osteogenic differentiation of mesenchymal stem cells

Cited by 90 publications

References 58 publications

Conformational changes influence clogging behavior of micrometer-sized microgels in idealized multiple constrictions

Conformational changes influence clogging behavior of micrometer-sized microgels in idealized multiple constrictions

An Updated Review of Macro, Micro, and Nanostructured Hydrogels for Biomedical and Pharmaceutical Applications

Fabrication of tough, anisotropic, chemical-crosslinker-free poly(vinyl alcohol) nanofibrous cryogels via electrospinning

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