Injectable conductive gelatin methacrylate / oxidized dextran hydrogel encapsulating umbilical cord mesenchymal stem cells for myocardial infarction treatment

Zhu, Shuoji; Yu, Changjiang; Liu, Nanbo; Zhao, Mingyi; Chen, Zerui; Liu, Jian; Li, Ge; Huang, Huanlei; Guo, Huiming; Sun, Tucheng; Chen, Jimei; Zhuang, Jian; Zhu, Ping

doi:10.1016/j.bioactmat.2021.11.011

Cited by 58 publications

(62 citation statements)

References 53 publications

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“…Then, we modified chitosan with abundant biomedical advantages using glycidyltrimethylammonium chloride (GTMAC) to synthesize QCS with better water solubility than chitosan, which could effectively deal with drug-resistant bacteria (Figure a) . Natural polysaccharide dextran was oxidized through sodium periodate (SP) to obtain multiple aldehyde groups (Figure b) . QCS with amino groups and OD with multiple aldehyde groups serve as the basic skeleton structure of the hydrogels through Schiff base reaction (QCS/OD hydrogel).…”

Section: Resultsmentioning

confidence: 99%

“…40 Natural polysaccharide dextran was oxidized through sodium periodate (SP) to obtain multiple aldehyde groups (Figure 1b). 41 QCS with amino groups and OD with multiple aldehyde groups serve as the basic skeleton structure of the hydrogels through Schiff base reaction (QCS/OD hydrogel). TOB with multiple amino groups can also undergo Schiff base reactions with OD as a small-molecule cross-linker (QCS/OD/TOB hydrogel), and this enables TOB to be slowly released and responsive to pH.…”

Section: Resultsmentioning

confidence: 99%

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Bacterial Growth-Induced Tobramycin Smart Release Self-Healing Hydrogel for Pseudomonas aeruginosa-Infected Burn Wound Healing

et al. 2022

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Burns are a common health problem worldwide and are highly susceptible to bacterial infections that are difficult to handle with ordinary wound dressings. Therefore, burn wound repair is extremely challenging in clinical practice. Herein, a series of self-healing hydrogels (QCS/OD/TOB/PPY@PDA) with good electrical conductivity and antioxidant activity were prepared on the basis of quaternized chitosan (QCS), oxidized dextran (OD), tobramycin (TOB), and polydopaminecoated polypyrrole nanowires (PPY@PDA NWs). These Schiff base crosslinks between the aminoglycoside antibiotic TOB and OD enable TOB to be slowly released and responsive to pH. Interestingly, the acidic substances during the bacteria growth process can induce the on-demand release of TOB, avoiding the abuse of antibiotics. The antibacterial results showed that the QCS/OD/TOB/PPY@PDA9 hydrogel could kill high concentrations of Pseudomonas aeruginosa (PA), Staphylococcus aureus, and Escherichia coli in a short time and showed a bactericidal effect for up to 11 days in an agar plate diffusion experiment, while showing good in vivo antibacterial activity. Excellent and long-lasting antibacterial properties make it suitable for severely infected wounds. Furthermore, the incorporation of PPY@PDA endowed the hydrogel with near-infrared (NIR) irradiation assisted bactericidal activity of drug-resistant bacteria, conductivity, and antioxidant activity. Most importantly, in the PA-infected burn wound model, the QCS/OD/TOB/PPY@PDA9 hydrogel more effectively controlled wound inflammation levels and promoted collagen deposition, vascular generation, and earlier wound closure compared to Tegaderm dressings. Therefore, the TOB smart release hydrogels with on-demand delivery are extremely advantageous for bacterial-infected burn wound healing.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Bacterial Growth-Induced Tobramycin Smart Release Self-Healing Hydrogel for Pseudomonas aeruginosa-Infected Burn Wound Healing

et al. 2022

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“…GEL has been proposed as an interesting alternative in hydrogel applications, since it overcomes several disadvantages of its parent compound, i.e., COL. For example, bare COL hydrogels may induce adverse immunological responses, along with a lack of mechanical and thermal stability [ 152 , 166 ]. For these reasons, as well as its abundance and availability, GEL has been extensively investigated for biomedical applications, although several approaches have been proposed to enhance its properties, for example, hybridizing with other polymers [ 77 , 78 , 167 , 168 ], cross-linking strategies [ 169 , 170 ] and chemical modification [ 79 , 80 , 171 ]. As to biological performances, GEL-based hydrogels have resulted in excellent candidates for biomedical applications since they have remarkable biocompatibility (>90%) and durability once implanted in the body, not only maintaining their cell viability, but even increasing after 7 days, as reported by Liu et al (2022).…”

Section: Methodsmentioning

confidence: 99%

Novel Trends in Hydrogel Development for Biomedical Applications: A Review

et al. 2022

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Nowadays, there are still numerous challenges for well-known biomedical applications, such as tissue engineering (TE), wound healing and controlled drug delivery, which must be faced and solved. Hydrogels have been proposed as excellent candidates for these applications, as they have promising properties for the mentioned applications, including biocompatibility, biodegradability, great absorption capacity and tunable mechanical properties. However, depending on the material or the manufacturing method, the resulting hydrogel may not be up to the specific task for which it is designed, thus there are different approaches proposed to enhance hydrogel performance for the requirements of the application in question. The main purpose of this review article was to summarize the most recent trends of hydrogel technology, going through the most used polymeric materials and the most popular hydrogel synthesis methods in recent years, including different strategies of enhancing hydrogels’ properties, such as cross-linking and the manufacture of composite hydrogels. In addition, the secondary objective of this review was to briefly discuss other novel applications of hydrogels that have been proposed in the past few years which have drawn a lot of attention.

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“…PNIPAAm/SWCNTs hydrogels showed high bioactivity on BASCs (bone marrow mesenchymal stem cells), by promoting BASCs cell adhesion and proliferation, in comparison with PNIPAAm hydrogels alone. An injectable natural polymer hydrogel with electrical conductivity as a cell delivery vehicle not only has excellent biocompatibility and cell delivery ability for UCMSCs (umbilical cord mesenchymal stem cells), but more importantly, can promote the growth of UCMSCs, proliferation, and differentiation, thereby improving damaged myocardial tissue and rebuilding myocardial function [ 116 ]. The addition of chemokines to the hydrogel, such as SDF-1α (Stromal cell-derived factor-1 alpha), which promotes homing of stem cells in the infarcted area, also could increase their retention [ 117 ].…”

Section: Hydrogel As a Carrier For Transplanted Cellsmentioning

confidence: 99%

Research Advances of Injectable Functional Hydrogel Materials in the Treatment of Myocardial Infarction

Yang

Guo

et al. 2022

Gels

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Myocardial infarction (MI) has become one of the serious diseases threatening human life and health. However, traditional treatment methods for MI have some limitations, such as irreversible myocardial necrosis and cardiac dysfunction. Fortunately, recent endeavors have shown that hydrogel materials can effectively prevent negative remodeling of the heart and improve the heart function and long-term prognosis of patients with MI due to their good biocompatibility, mechanical properties, and electrical conductivity. Therefore, this review aims to summarize the research progress of injectable hydrogel in the treatment of MI in recent years and to introduce the rational design of injectable hydrogels in myocardial repair. Finally, the potential challenges and perspectives of injectable hydrogel in this field will be discussed, in order to provide theoretical guidance for the development of new and effective treatment strategies for MI.

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Injectable conductive gelatin methacrylate / oxidized dextran hydrogel encapsulating umbilical cord mesenchymal stem cells for myocardial infarction treatment

Cited by 58 publications

References 53 publications

Bacterial Growth-Induced Tobramycin Smart Release Self-Healing Hydrogel for Pseudomonas aeruginosa-Infected Burn Wound Healing

Bacterial Growth-Induced Tobramycin Smart Release Self-Healing Hydrogel for Pseudomonas aeruginosa-Infected Burn Wound Healing

Novel Trends in Hydrogel Development for Biomedical Applications: A Review

Research Advances of Injectable Functional Hydrogel Materials in the Treatment of Myocardial Infarction

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