Injectable biodegradable polymer composites based on poly(propylene fumarate) crosslinked with poly(ethylene glycol)-dimethacrylate

He, Shulin; Yaszemski, Michael J.; Yasko, Alan W.; Engel, Paul S.; Mikos, Antonios G.

doi:10.1016/s0142-9612(00)00106-x

Cited by 199 publications

(140 citation statements)

References 14 publications

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“…As a result, quicksetting and degradable biocomposite cements with a low heat output and compressive strengths in the range of 1-12 MPa could be prepared by varying the molecular weight of PPF as well as the contents of the monomer, β-TCP initiator and NaCl as a porogen. 548, 549 An acrylic cement with Sr-containing HA as a filler, 138 an injectable polydimethylsiloxane/HA cement, 550 biocomposites consisting of PLGA microspheres and a calcium orthophosphate cement 551,552 as well as a hybrid cement formulation of chitosan oligosaccharide/gelatin/calcium orthophosphate 553 were prepared as well.…”

Section: O N O T D I S T R I B U T Ementioning

confidence: 99%

Biocomposites and hybrid biomaterials based on calcium orthophosphates

Dorozhkin¹

2011

Biomatter

152

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Section: O N O T D I S T R I B U T Ementioning

confidence: 99%

Biocomposites and hybrid biomaterials based on calcium orthophosphates

Dorozhkin¹

2011

Biomatter

152

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“…To mimic PMMA cements, PFF/ b-TCP biocomposites were prepared with the addition of vinyl monomer to crosslink PPF. As a result, quick setting and degradable biocomposite cements with a low-heat output and compressive strengths in the range of 1 to 12 MPa were prepared by varying the molecular weight of PPF, as well as the contents of the monomer, b-TCP, initiator, and porogen (NaCl) [453,454]. An acrylic cement with Sr-containing HA as a filler [110] and an injectable polydimethylsiloxane/HA cement [455] have been prepared as well.…”

Section: Calcium Orthophosphate Cement-based Biocomposites and Concretesmentioning

confidence: 99%

Calcium orthophosphate-based biocomposites and hybrid biomaterials

Dorozhkin¹

2009

J Mater Sci

283

146

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“…In order to fulfill all these requirements, several polymers have been tested as injectable materials. Some of them include chitosan (2,3), Na-alginate (4), hyaluronic acid (5,6), hydroxypropylmethylcellulose (HPMC; 7-10), carboxymethylcellulose (NaCMC; 11), poly(propylene fumarate) (12,13), poly(ethylene glycol)-dimethacrylate), poly(β-caprolactone) (14), carboxylmethyl chitin (15), polymethylmetacrylate, and others (16). However, the use of specific solid particles in suspension requires an optimization of the vehicles in terms of their viscosity, injectability, and stability.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Polymeric Solutions as Injectable Vehicles for Hydroxyapatite Microspheres

et al. 2010

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Abstract.A polymeric solution and a reinforcement phase can work as an injectable material to fill up bone defects. However, the properties of the solution should be suitable to enable the transport of that extra phase. Additionally, the use of biocompatible materials is a requirement for tissue regeneration. Thus, we intended to optimize a biocompatible polymeric solution able to carry hydroxyapatite microspheres into bone defects using an orthopedic injectable device. To achieve that goal, polymers usually regarded as biocompatible were selected, namely sodium carboxymethylcellulose, hydroxypropylmethylcellulose, and Na-alginate (ALG). The rheological properties of the polymeric solutions at different concentrations were assessed by viscosimetry before and after moist heat sterilization. In order to correlate rheological properties with injectability, solutions were tested using an orthopedic device applied for minimal invasive surgeries. Among the three polymers, ALG solutions presented the most suitable properties for our goal and a non-sterile ALG 6% solution was successfully used to perform preliminary injection tests of hydroxyapatite microspheres. Sterile ALG 7.25% solution was found to closely match non-sterile ALG 6% properties and it was selected as the optimal vehicle. Finally, sterile ALG 7.25% physical stability was studied at different temperatures over a 3-month period. It was observed that its rheological properties presented minor changes when stored at 25°C or at 4°C.

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Injectable biodegradable polymer composites based on poly(propylene fumarate) crosslinked with poly(ethylene glycol)-dimethacrylate

Cited by 199 publications

References 14 publications

Biocomposites and hybrid biomaterials based on calcium orthophosphates

Biocomposites and hybrid biomaterials based on calcium orthophosphates

Calcium orthophosphate-based biocomposites and hybrid biomaterials

Characterization of Polymeric Solutions as Injectable Vehicles for Hydroxyapatite Microspheres

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