Injectable and degradable methacrylic acid hydrogel alters macrophage response in skeletal muscle

Carleton, Miranda M.; Sefton, Michael V.

doi:10.1016/j.biomaterials.2019.119477

Cited by 43 publications

(29 citation statements)

References 48 publications

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“…34,35 Among these paracrine effects, the immunomodulation ability, such as modulation of the switch of the macrophages from M1 to M2 phenotype, and the benecial reprogramming events play particularly crucial roles in tissue engineering to promote tissue repair. 36,37 Li et al 38 also showed that rBMSCs could reverse the phenotype switch of macrophages induced by LAP, inhibit proinammatory cytokines, and promote the production of anti-inammatory factors and osteo-related cytokines in vitro and in vivo. However, the recruitment of MSCs by the implanted scaffold in vivo also needs 7 days, with anti-inammatory macrophages which could release high levels of immunomodulatory factors to bring tissue-forming MSCs to the site of damage.…”

Section: Nanocomposite Hydrogel Supports Cell Viability and Proliferation In Vitromentioning

confidence: 99%

Cell-loaded injectable gelatin/alginate/LAPONITE® nanocomposite hydrogel promotes bone healing in a critical-size rat calvarial defect model

Liu

Lei

et al. 2020

RSC Adv.

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Section: Nanocomposite Hydrogel Supports Cell Viability and Proliferation In Vitromentioning

confidence: 99%

Cell-loaded injectable gelatin/alginate/LAPONITE® nanocomposite hydrogel promotes bone healing in a critical-size rat calvarial defect model

Liu

Lei

et al. 2020

RSC Adv.

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“…Materials such as chitosan, [ 145 , 146 ] hyaluronic acid (HA), [ 147 ] PLGA, [ 148 , 149 ] PEG, [ 150 , 151 ] poly ( d , l ‐lactide‐ co ‐ ε ‐caprolactone) (PDLLCL), [ 152 ] and methacrylic acid‐based materials [ 153 , 154 , 155 , 156 ] have been employed in the contexts of islet transplantation and local immunomodulation. For example, Smink et al., constructed a microporous scaffold consisting of PDLLCL and demonstrated a low inflammation score when compared to similar scaffolds.…”

Section: Local Immunomodulation Strategiesmentioning

confidence: 99%

Local Immunomodulatory Strategies to Prevent Allo‐Rejection in Transplantation of Insulin‐Producing Cells

et al. 2021

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Islet transplantation has shown promise as a curative therapy for type 1 diabetes (T1D). However, the side effects of systemic immunosuppression and limited long-term viability of engrafted islets, together with the scarcity of donor organs, highlight an urgent need for the development of new, improved, and safer cell-replacement strategies. Induction of local immunotolerance to prevent allo-rejection against islets and stem cell derived cells has the potential to improve graft function and broaden the applicability of cellular therapy while minimizing adverse effects of systemic immunosuppression. In this mini review, recent developments in non-encapsulation, local immunomodulatory approaches for T1D cell replacement therapies, including islet/ cell modification, immunomodulatory biomaterial platforms, and co-transplantation of immunomodulatory cells are discussed. Key advantages and remaining challenges in translating such technologies to clinical settings are identified. Although many of the studies discussed are preliminary, the growing interest in the field has led to the exploration of new combinatorial strategies involving cellular engineering, immunotherapy, and novel biomaterials. Such interdisciplinary research will undoubtedly accelerate the development of therapies that can benefit the whole T1D population.

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“…Injectable hydrogels have become increasingly popular as they are minimally invasive and can contour around the site of injury 60,67 . Several hydrogels have been used for skeletal muscle tissue engineering, including injectable forms of collagen, 68 alginate, 69‐71 poly(ethylene glycol), 72 fibrin 73,74 and keratin 13 . These will be further discussed in the following sections.…”

Section: Biomaterials For Skeletal Muscle Regenerationmentioning

confidence: 99%

Promoting endogenous repair of skeletal muscle using regenerative biomaterials

Carleton

Sefton

2021

J Biomedical Materials Res

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Skeletal muscles normally have a remarkable ability to repair themselves; however, large muscle injuries and several myopathies diminish this ability leading to permanent loss of function. No clinical therapy yet exists that reliably restores muscle integrity and function following severe injury. Consequently, numerous tissue engineering techniques, both acellular and with cells, are being investigated to enhance muscle regeneration. Biomaterials are an essential part of these techniques as they can present physical and biochemical signals that augment the repair process. Successful tissue engineering strategies require regenerative biomaterials that either actively promote endogenous muscle repair or create an environment supportive of regeneration. This review will discuss several acellular biomaterial strategies for skeletal muscle regeneration with a focus on those under investigation in vivo. This includes materials that release bioactive molecules, biomimetic materials and immunomodulatory materials.

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Injectable and degradable methacrylic acid hydrogel alters macrophage response in skeletal muscle

Cited by 43 publications

References 48 publications

Cell-loaded injectable gelatin/alginate/LAPONITE® nanocomposite hydrogel promotes bone healing in a critical-size rat calvarial defect model

Cell-loaded injectable gelatin/alginate/LAPONITE® nanocomposite hydrogel promotes bone healing in a critical-size rat calvarial defect model

Local Immunomodulatory Strategies to Prevent Allo‐Rejection in Transplantation of Insulin‐Producing Cells

Promoting endogenous repair of skeletal muscle using regenerative biomaterials

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