Initiation of c-ART in HIV-1 Infected Patients Is Associated With a Decrease of the Metabolic Activity of the Thymus Evaluated Using FDG-PET/Computed Tomography

Lelièvre, Jean‐Daniel; Melica, Giovanna; Itti, Emmanuel; Lacabaratz, Christine; Rozlan, Sandra; Wiedemann, Aurélie; Cheynier, Rémi; Meignan, Michel; Thiébaut, Rodolphe; Lévy, Yves

doi:10.1097/qai.0b013e3182615b62

Cited by 15 publications

(5 citation statements)

References 47 publications

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“…Our results demonstrate the maintenance of effective lymphopoiesis in HIV-2 infection, which is likely to be linked with a capacity to sustain the long-term production of naive CD8 + T cells. In HIV-1 infection, the progressive decrease in naive T cell proportions in HIV-infected adults likely results from the Ag-driven maturation of these cells in the absence of adequate T cell renewal capacity because of the declining thymic output of new cells (8,10,24). We and others previously reported that thymic function is preserved in HIV-2-infected individuals with low viral load (25).…”

Section: Cd45ramentioning

confidence: 99%

Preservation of Lymphopoietic Potential and Virus Suppressive Capacity by CD8+ T Cells in HIV-2–Infected Controllers

Angin

Wong

Papagno

et al. 2016

The Journal of Immunology

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Compared with HIV-1, HIV-2 infection is characterized by a larger proportion of slow or nonprogressors. A better understanding of HIV-2 pathogenesis should open new therapeutic avenues to establish control of HIV-1 replication in infected patients. In this study, we studied the production of CD8+ T cells and their capacity for viral control in HIV-2 controllers from the French ANRS CO5 HIV-2 cohort. HIV-2 controllers display a robust capacity to support long-term renewal of the CD8+ T cell compartment by preserving immune resources, including hematopoietic progenitors and thymic activity, which could contribute to the long-term maintenance of the CD8+ T cell response and the avoidance of premature immune aging. Our data support the presence of HIV-2 Gag–specific CD8+ T cells that display an early memory differentiation phenotype and robust effector potential in HIV-2 controllers. Accordingly, to our knowledge, we show for the first time that HIV-2 controllers possess CD8+ T cells that show an unusually strong capacity to suppress HIV-2 infection in autologous CD4+ T cells ex vivo, an ability that likely depends on the preservation of host immune resources. This effective and durable antiviral response probably participates in a virtuous circle, during which controlled viral replication permits the preservation of potent immune functions, thus preventing HIV-2 disease progression.

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Section: Cd45ramentioning

confidence: 99%

Preservation of Lymphopoietic Potential and Virus Suppressive Capacity by CD8+ T Cells in HIV-2–Infected Controllers

Angin

Wong

Papagno

et al. 2016

The Journal of Immunology

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“…As expected, the results of this study showed lower percentage of naive CD8 T cells in HIVinfected MSM compared to uninfected controls. This may be partially explained by the capacity of the thymus to produce new T cells or thymic output, which is signi cantly decreased during the course of HIV infection [31][32][33]. Moreover, our results indicate that naive CD8 T cells in HIV-infected MSM are more activated and show a more replicative senescence phenotype.…”

Section: Discussionmentioning

confidence: 73%

Accelerated Immune Senescence and Biological Aging of T-cell Subsets Among ART-naive HIV-infected Men Who Have Sex With Men in Beijing, China: a Case-control Study

Wang

et al. 2021

Preprint

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Background: The average lifespan of HIV-infected subjects remains shorter compared to uninfected individuals. Accelerated senescence may be responsible for this difference despite effective antiretroviral therapy (ART) with successful viral suppression. The present study aimed to assess the impact of HIV on immune and biological senescence of ART-naive HIV-infected men who have sex with men (MSM) in Beijing, China. Methods: A cross-sectional study was conducted that compared MSM HIV-infected patients and age-matched MSM HIV negative controls. Within the CD4 and CD8 population, the percentages of naive(TN), central memory(TCM), effector memory(TEM) and terminally differentiated memory(TemRA) subsets were studied and markers of senescence and activation in these cells were measured by multiparameter flow cytometry. Naive (CD45RA+) and memory (CD45RO+) CD8 T cells were purified by MACS technology. Telomere length was quantified by real-time PCR. Results: Within the CD8 T cell subsets, TN, TCM,TEM and TemRA cells showed more activation (HLA-DR+) and replicative senescence(CD28-CD57+) phenotypes in ART-naive MSM. However, in the CD4 T cell subsets, expect for TN, the percentage of senescent cells did not differ between ART-naive MSM and uninfected controls, but activated cells were upregulated in the former. The telomere length of naive and memory CD8 T cells was significantly shorter in ART-naive MSM than that of uninfected controls.Conclusion: Our results indicate that HIV-infected ART-naive MSM exhibit accelerated immune senescence with premature biological aging, which particularly affects the CD8 T-cell subsets. This highlights the strong impact of HIV on aging process of T-cell despite patient’s young age at infection and supports the importance of early control of HIV replication.

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“…Lilievere et al 2012 [18] J Acquire immune Defic Syndr Clinical Evaluated thymic activity with FDG uptake and precursors for thymic activity. Thymic uptake was lower in HAART-treated patients compared with age-matched controls.…”

Section: Liu Et Al 2009mentioning

confidence: 99%

“…In HIV-infected patients treated with HAART metabolic uptake in the thymus has been shown to be a non-invasive marker of thymic output. Patients without thymic uptake showed a poor CD4 recovery after initiation of HAART [13,17,18]. In adults and particularly when infected with HIV virus, the thymus is inactive due to involution of the thymus and the destruction of CD4 Tlymphocytes by the virus.…”

Section: Fdg Uptake In Lymphoid Tissue In Relation To the Stage And Imentioning

confidence: 99%

The Role of Nuclear Medicine in the Staging and Management of Human Immune Deficiency Virus Infection and Associated Diseases

Ankrah

Glaudemans

Klein

et al. 2016

Nucl Med Mol Imaging

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Human immune deficiency virus (HIV) is a leading cause of death. It attacks the immune system, thereby rendering the infected host susceptible to many HIV-associated infections, malignancies and neurocognitive disorders. The altered immune system affects the way the human host responds to disease, resulting in atypical presentation of these disorders. This presents a diagnostic challenge and the clinician must use all diagnostic avenues available to diagnose and manage these conditions. The advent of highly active antiretroviral therapy (HAART) has markedly reduced the mortality associated with HIV infection but has also brought in its wake problems associated with adverse effects or drug interaction and may even modulate some of the HIV-associated disorders to the detriment of the infected human host. Nuclear medicine techniques allow non-invasive visualisation of tissues in the body. By using this principle, pathophysiology in the body can be targeted and the treatment of diseases can be monitored. Being a functional imaging modality, it is able to detect diseases at the molecular level, and thus it has increased our understanding of the immunological changes in the infected host at different stages of the HIV infection. It also detects pathological changes much earlier than conventional imaging based on anatomical changes. This is important in the immunocompromised host as in some of the associated disorders a delay in diagnosis may have dire consequences. Nuclear medicine has played a huge role in the management of many HIV-associated disorders in the past and continues to help in the diagnosis, prognosis, staging, monitoring and assessing the response to treatment of many HIV-associated disorders. As our understanding of the molecular basis of disease increases nuclear medicine is poised to play an even greater role. In this review we highlight the functional basis of the clinicopathological correlation of HIV from a metabolic view and discuss how the use of nuclear medicine techniques, with particular emphasis of F-18 fluorodeoxyglucose, may have impact in the setting of HIV. We also provide an overview of the role of nuclear medicine techniques in the management of HIV-associated disorders.

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Initiation of c-ART in HIV-1 Infected Patients Is Associated With a Decrease of the Metabolic Activity of the Thymus Evaluated Using FDG-PET/Computed Tomography

Abstract: A metabolic thymic activity is detectable in c-ART naive and correlates with indirect phenotypic and molecular markers of thymic output. This activity may participate to the pool of peripheral naive CD4+ T cells and predicts the magnitude of T-cell reconstitution under treatment.

Cited by 15 publications

References 47 publications

Preservation of Lymphopoietic Potential and Virus Suppressive Capacity by CD8+ T Cells in HIV-2–Infected Controllers

Preservation of Lymphopoietic Potential and Virus Suppressive Capacity by CD8+ T Cells in HIV-2–Infected Controllers

Accelerated Immune Senescence and Biological Aging of T-cell Subsets Among ART-naive HIV-infected Men Who Have Sex With Men in Beijing, China: a Case-control Study

The Role of Nuclear Medicine in the Staging and Management of Human Immune Deficiency Virus Infection and Associated Diseases

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