2021
DOI: 10.3390/jcm10245892
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Abstract: The main aim of this work was to determine the impact of COMT and DRD2 gene polymorphisms together with temperament and character traits on alcohol craving severity alcohol-dependent persons. The sample comprised of 89 men and 16 women (aged 38±7). For the sake of psychological assessment various analytic methods have been applied like the Short Alcohol Dependence Data Questionnaire (SADD), Penn Alcohol Craving Scale (PACS) or Temperament and Character Inventory (TCI) test. The SNP polymorphism of the analyzed… Show more

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Cited by 3 publications
(2 citation statements)
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References 83 publications
(110 reference statements)
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“…Factors predisposing individuals to the development of psychiatric disorders and their markers are infectious/immune, metabolic, and environmental (e.g., stress, atmospheric, dietetical, etc.) and also (epi)genetic and neoplastic aetiology [54,55]. An example of difficulties in aetiological interpretation in psychiatric research is explaining the formation of mood disorders by only one factor, e.g., dietary changes.…”
Section: Discussionmentioning
confidence: 99%
“…Factors predisposing individuals to the development of psychiatric disorders and their markers are infectious/immune, metabolic, and environmental (e.g., stress, atmospheric, dietetical, etc.) and also (epi)genetic and neoplastic aetiology [54,55]. An example of difficulties in aetiological interpretation in psychiatric research is explaining the formation of mood disorders by only one factor, e.g., dietary changes.…”
Section: Discussionmentioning
confidence: 99%
“…The SNP loci of catechol-O-methyl transferase(COMT:rs4680, rs165599, and rs737865) was relevant to cognitive competence [24]. The translational product of COMT gene plays a key role in clearing catecholamines (such as dopamine, epinephrine and norepinephrine) in human brain [25]. Small et al…”
Section: Introductionmentioning
confidence: 99%