Initial Parafoveal Versus Peripheral Scotomas in Glaucoma: Risk Factors and Visual Field Characteristics

Park, Sung Chul; Moraes, Carlos Gustavo De; Teng, Christopher C.; Tello, Celso; Liebmann, Jeffrey M.; Ritch, Robert

doi:10.1016/j.ophtha.2011.02.013

Cited by 178 publications

(177 citation statements)

References 41 publications

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“…region is considered to be more strongly associated with vascular abnormalities, [15][16][17] in addition to overall POAG, we evaluated subtypes of POAG defined by the type of VF loss separately (POAG with early VF loss in the paracentral region and POAG with VF loss in the peripheral region only), to investigate differences in association.…”

Section: Defining the Vascular Tone Pathway And Analysis Of The Wholementioning

confidence: 99%

“…This is consistent with previous findings showing associations between the POAG subtype showing early paracentral VF loss with systemic vascular dysregulation. 15,17 Among the limitations of this study, first, we lacked replication of the gene-based analyses as there is currently no other data set of comparable size for replication. Thus, although suggestive, these gene-based exploratory analyses, especially in relation to the subtype of POAG with early paracentral VF loss, should be interpreted with caution and replicated.…”

Section: Proteinmentioning

confidence: 99%

“…Thus, although suggestive, these gene-based exploratory analyses, especially in relation to the subtype of POAG with early paracentral VF loss, should be interpreted with caution and replicated. Second, this study was restricted to Caucasians and, therefore, the generalizability of these results to other populations, especially East Asian populations with generally lower IOP, 15,17,57 is limited.…”

Section: Proteinmentioning

confidence: 99%

“…Of note, POAG patients with initial paracentral VF loss are particularly more likely to have systemic vascular risk factors, such as hypotension and migraines. [15][16][17] Many studies support the role of vascular factors in glaucoma. Large epidemiologic studies have observed adverse associations with low ocular perfusion pressure 18 or low systemic blood pressure, 19 and open-angle glaucoma frequency or risk.…”

Section: Introductionmentioning

confidence: 99%

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Vascular tone pathway polymorphisms in relation to primary open-angle glaucoma

Kang

Loomis

Yaspan³

et al. 2014

Eye

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Section: Defining the Vascular Tone Pathway And Analysis Of The Wholementioning

confidence: 99%

Section: Proteinmentioning

confidence: 99%

Section: Proteinmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Vascular tone pathway polymorphisms in relation to primary open-angle glaucoma

Kang

Loomis

Yaspan³

et al. 2014

Eye

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“…They are often associated with glaucomatous damage. In fact, Park et al 27 observed that patients with damage within the central 10° on the 24-2 were more likely to have disc hemorrhages than those with comparable damage (nasal steps) outside the central 10°.…”

Section: 15mentioning

confidence: 99%

Does OCT Angiography of Macula Play a Role in Glaucoma Diagnostics?

Курышева¹

2017

Ophthalmol Open J

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CitationKurysheva NI. Does OCT angiography of macula play a role in glaucoma diagnostics? Ophthalmol Open J. 2016; 2(1): 1-11. doi: 10.17140/OOJ-2-107 Copyright ©2016 Kurysheva NI. This is an open access article distributed under the Creative Commons Attribution 4.0 International License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. To assess vascularity of the macular area in patients with glaucoma using optical coherence tomography angiography (OCT-A) and evaluate the role of its examination in early glaucoma diagnosis. Materials and Methods: Thirty-eight eyes of patients with the early stage of primary open-angle glaucoma (POAG), 27 eyes of patients with the advanced and far-advanced stages of POAG, and 22 eyes of age-matched healthy subjects were examined using spectral-domain OCT-A (SD-OCT-А) (RtVue xR Avanti with the AngioVue software, San Jose, CA, USA) in order to measure retinal thickness and angio flow density (AFD) retina in macula (an area bounded by a circle with a diameter of 3 mm), inсluding fovea and parafovea regions (superficial and deep) of the inner retinal layers. The AFD disc and peripapillary flow density were measured in optic nerve head (ONH) and 750-μm-wide elliptical annulus extending from the optic disc boundary. Retrobulbar blood flow parameters, including ophthalmic artery (OA), central retinal artery (CRA), short posterior ciliary arteries (PCAs), central retinal vein (CRV), and vortex veins (VV), were measured by color doppler imaging (CDI). The average thickness of the ganglion cell complex (avg GCC), retinal nerve fiber layer (RNFL), and choroid, as well as the focal loss volume (FLV) and global loss volume (GLV) of GCC were measured by means of SD-OCT. Automated perimetry was performed using Humphrey perimeter (Carl Zeiss Meditec, Dublin, CA, USA). Corneal-compensated intraocular pressure (IOPcc) and corneal hysteresis (CH) were determined using ocular response analyzer. Mean ocular perfusion pressure (MOPP) was calculated by measuring IOP and arterial blood pressure (BP) immediately prior to OCT and using formula: MOPP = (2/3 diastolic BP + 1/3 systolic BP) × 2/3 -IOP. Statistical analysis was performed using SPSS version 21 and MASS library in the R language. As a measure of the parameter's importance in distinguishing patient groups, a value of the adjusted standardized statistic of the Mann-Whitney test (z-value) and an area under the receiver operating characteristic (ROC) curve (AUC) were used. Results: Although all structural parameters and indices of retrobulbar blood flow were reduced in early glaucoma as compared to the normal controls, the following parameters were the main discrepancy criteria when discriminating these patient groups: macular vascular density-AFD Retina Superficial Whole En Face (z=3.86, p<0.0001;) and macular thickness in the inferior sector p<0.0001;). In discriminating early glaucoma from the advanced and far advanced stages of the disease, the most usefu...

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Prevalence and Nature of Early Glaucomatous Defects in the Central 10° of the Visual Field

et al. 2014

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There appeared to be as many abnormal 10-2 hemifields (53%) as abnormal 24-2 hemifields (59%). Of the eyes with normal 24-2 hemifields, 16% were classified as abnormal when the 10-2 test was used. Of the abnormal 10-2 hemifields, 68%, 8%, and 25% were arcuatelike, widespread, and other, respectively. The average total deviation values and number of abnormal points plots revealed superior VF defects that were deeper and closer to fixation than those in the inferior VF. CONCLUSIONS AND RELEVANCEThe 10-2 VF was abnormal in nearly as many hemifields as was the 24-2 VF, including some with normal 24-2 VF, suggesting that the 24-2 test is not optimal for detecting early damage of the macula. The pattern of the defects was in agreement with a recent model of macular damage.

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Initial Parafoveal Versus Peripheral Scotomas in Glaucoma: Risk Factors and Visual Field Characteristics

Cited by 178 publications

References 41 publications

Vascular tone pathway polymorphisms in relation to primary open-angle glaucoma

Vascular tone pathway polymorphisms in relation to primary open-angle glaucoma

Does OCT Angiography of Macula Play a Role in Glaucoma Diagnostics?

Prevalence and Nature of Early Glaucomatous Defects in the Central 10° of the Visual Field

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