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Cited by 72 publications
(55 citation statements)
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References 42 publications
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“…The majority of identified missense mutations in all LPHN are clustered in their extracellular domains, the GAIN domain being the most targeted for LPHN3 in either cancer or ADHD samples. (107). These mice displayed a hyperactive phenotype in behavioral tests and were more sensitive to the locomotor stimulant effects of cocaine, which is consistent with reward pathway-associated defects seen in ADHD patients.…”
Section: Attention-deficit Hyperactivity Disordermentioning
confidence: 53%
“…The majority of identified missense mutations in all LPHN are clustered in their extracellular domains, the GAIN domain being the most targeted for LPHN3 in either cancer or ADHD samples. (107). These mice displayed a hyperactive phenotype in behavioral tests and were more sensitive to the locomotor stimulant effects of cocaine, which is consistent with reward pathway-associated defects seen in ADHD patients.…”
Section: Attention-deficit Hyperactivity Disordermentioning
confidence: 53%
“…Altered LPHN3 expression levels have been seen after brain ischemia (Bin et al, 2002), and during the period of adrenal gland development (Wing et al, 2009). LPHN3-deficient mice display evidence of profound disruption at multiple monoamine-signalling levels, causing attention deficit-hyperactivity disorder (ADHD), the most common psychiatric disorder in childhood and adolescence (Wallis et al, 2012). MMP13 or collagenase-3 is a member of the matrix metalloproteinase family of endopeptidases that have potent degrading activity for degrading the major protein components of the extracellular matrix and basement membranes of the cells (PendĂĄs et al, 2000).…”
Section: Discussionmentioning
confidence: 99%
“…SNPs in ADGRL3 (LPHN3) are a risk factor for attention deficit/hyperactivity disorder (Arcos-Burgos et al, 2010;Domene et al, 2011;RibasĂ©s et al, 2011). Loss of Adgrl3 (Lphn3) function in mice and zebrafish disturbs dopaminergic brain circuits, leading to a hyperactive/impulsive phenotype, which can be rescued by anti-attention deficit/hyperactivity disorder drugs (Lange et al, 2012;Wallis et al, 2012).…”
Section: Skeletal Muscle and Bonementioning
confidence: 99%