Inhibitory potentials and kinetics of the inhibition of carbohydrate-hydrolysing enzymes by the pod and seed extracts of Lessertia montana (Fabaceae) E. Phillips &amp; R.A. Dyer

doi:10.7324/japs.2019.90107

Cited by 3 publications

(1 citation statement)

References 110 publications

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“…montana, also known as Mountain Balloon Pea and formerly known as Sutherlandia montana, is a plant species with medicinal value that is native to South Africa and belonging to the Fabaceae family. It is a soft-wooded shrub with silvery green leaves, large red flowers, bladdery pods and grows to heights of about 0.5-1.0 m. In South Africa, the Basotho people from the eastern Free State province traditionally use the leaf infusion as a sedative and for treatment of heart diseases [78]. Ashafa and Alimi [79] screened L. montana leaf decoctions for phytochemicals and reported the presence of saponins, cardiac glycosides, alkaloids, phenols, triterpenes, phytosterols, and flavonoids.…”

Section: Lessertia Montanamentioning

confidence: 99%

A Review of the Green Synthesis of ZnO Nanoparticles Utilising Southern African Indigenous Medicinal Plants

2022

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Metal oxide nanoparticles (NPs), such as zinc oxide (ZnO), have been researched extensively for applications in biotechnology, photovoltaics, photocatalysis, sensors, cosmetics, and pharmaceuticals due to their unique properties at the nanoscale. ZnO NPs have been fabricated using conventional physical and chemical processes, but these techniques are limited due to the use of hazardous chemicals that are bad for the environment and high energy consumption. Plant-mediated synthesis of ZnO NPs has piqued the interest of researchers owing to secondary metabolites found in plants that can reduce Zn precursors and stabilise ZnO NPs. Thus, plant-mediated synthesis of ZnO NPs has become one of the alternative green synthesis routes for the fabrication of ZnO NPs. This is attributable to its environmental friendliness, simplicity, and the potential for industrial-scale expansion. Southern Africa is home to a large and diverse indigenous medicinal plant population. However, the use of these indigenous medicinal plants for the preparation of ZnO NPs is understudied. This review looks at the indigenous medicinal plants of southern Africa that have been used to synthesise ZnO NPs for a variety of applications. In conclusion, there is a need for more exploration of southern African indigenous plants for green synthesis of ZnO NPs.

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Section: Lessertia Montanamentioning

confidence: 99%

A Review of the Green Synthesis of ZnO Nanoparticles Utilising Southern African Indigenous Medicinal Plants

2022

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In vitro anti-diabetic activity of Tribulus terrestrisL. fruits extracts

AlKhaldi

Daghestani

Al-Haddad

2019

NFS

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Purpose The purpose of this paper is to evaluate the inhibition activity of Tribulus terrestris L. (T. terrestris) fruits extracts with solvents of increasing polarity against α-glucosidase and α-amylase, and to determine the inhibition mode of the most effective extract against both enzymes. Design/methodology/approach Hexane, acetone, ethanol and aqueous extracts of T. terrestris fruits were prepared using ultrasonic sequential extraction and analyzed for their α-amylase and α-glucosidase inhibitory activities by specific assay for each enzyme. The modes of inhibitions were detected using Lineweaver–Burk plots. Findings T. terrestris fruits extracts showed inhibition activity against α-glucosidase and α-amylase which was in the dose-dependent manner. Hexane extract had the highest α-glucosidase inhibition activity (IC50 = 27.28 μg/ml, p = 0.003), followed by acetone and ethanol extracts (IC50 = 60.58 μg/ml and IC50 = 84.21 μg/ml, respectively). The inhibition mode of hexane extract was noncompetitive. While acetone extract showed the highest inhibition activity against α-amylase (IC50 = 6.18 mg/ml, p = 0.002), hexane and ethanol extracts showed no significant difference (IC50 = 13.04 mg/ml and IC50 = 14.20 mg/ml, respectively, p = 0.09). The inhibition mode of acetone extract was competitive. Originality/value T. terrestris fruits extracts had strong inhibition activity against α-glucosidase and α-amylase, and they can be used as a promising anti-diabetic agent.

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Potentials of synthesised Lessertia montana zinc oxide nanoparticles on free radicals-mediated oxidative stress and carbohydrate-hydrolysing enzymes

Balogun

Ashafa

2021

Acta Biol Szeged

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The study evaluated the effects of green absorbed zinc oxide nanostructures on oxidative stress-mediated free radicals and carbohydrate-hydrolysing enzymes. The synthesised Lessertia montana zinc oxide nanoparticles were characterised using different spectroscopic, microscopic, and diffraction techniques. The activity of L. montana ZnONPs against 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethyl-benzothiazoline-6-sulfonic acid (ABTS), metal chelating assay, alpha-amylase and alphaglucosidase were determined using standard methods. L. montana ZnONPs were stable nanoparticles (NPs), appeared cubical (predominantly) in shape, and in nanometre range sizes. The synthesised NPs are very active (p < 0.05) against DPPH and alpha-glucosidase (0.120 and 0.037 g/L, respectively) when compared with other samples and controls, quercetin (0.349 g/L) and acarbose (0.065 g/L). However, their interaction with quercetin revealed a good ABTS (0.093 g/L) scavenging and an excellent metal chelating (0.027 g/L) effect compared to other samples. The mode of inhibition of alpha-amylase and alpha-glucosidase enzymes by L. montana ZnONPs was competitive and non-competitive, respectively. The study outcomes revealed that the synthesised ZnONPs possessed the potential to mitigate oxidative stress and diabetes in vitro.

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Inhibitory potentials and kinetics of the inhibition of carbohydrate-hydrolysing enzymes by the pod and seed extracts of Lessertia montana (Fabaceae) E. Phillips & R.A. Dyer

Abstract: In vitro assessment of the anti-diabetic activity of Sclerocarya birrea and Ziziphus mucronata

Cited by 3 publications

References 110 publications

A Review of the Green Synthesis of ZnO Nanoparticles Utilising Southern African Indigenous Medicinal Plants

A Review of the Green Synthesis of ZnO Nanoparticles Utilising Southern African Indigenous Medicinal Plants

In vitro anti-diabetic activity of Tribulus terrestrisL. fruits extracts

Potentials of synthesised Lessertia montana zinc oxide nanoparticles on free radicals-mediated oxidative stress and carbohydrate-hydrolysing enzymes

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