Inhibitory effects of quercetin on aflatoxin B1-induced hepatic damage in mice

Choi, Ki-Seok; Chung, Wan-Tae; Kwon, Jungkee; Yu, Ji‐Yeon; Jang, Yong-Suk; Park, S.-M.; Lee, S.-Y.; Lee, J.-C.

doi:10.1016/j.fct.2010.07.001

Cited by 100 publications

(81 citation statements)

References 33 publications

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“…The increase in MDA can be attributed to the significant decrease in both non-enzymatic antioxidant (GSH) and the activity of antioxidant enzyme (SOD) in liver and kidney homogenates of mice treated with AFs. Our findings of decrease in GSH contents and the activities of SOD corroborate with that of previous studies [48][49][50][51]. Thus significant decrease in GSH level will further aggravate the toxic effects of these mycotoxins.…”

Section: Discussionsupporting

confidence: 81%

Protective Effects of Lactobacillus rhamnosus GG on Aflatoxins-Induced Toxicities in Male Albino Mice

Deabes¹,

Darwish²,

B³

et al. 2012

J Environment Analytic Toxicol

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Section: Discussionsupporting

confidence: 81%

Protective Effects of Lactobacillus rhamnosus GG on Aflatoxins-Induced Toxicities in Male Albino Mice

Deabes¹,

Darwish²,

B³

et al. 2012

J Environment Analytic Toxicol

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“…The effects of ozone treatment on Total Antioxidant Capacity (TAC) and GSH are presented in (Table 3). The decrease in (TAC) with AFB 1 group might indirectly lead to an increase in oxidative DNA damage [25]. The GSH level decreased in animal feed on AFB1-contaminated wheat when compared with the control or the treated groups.…”

Section: The Biochemical Studymentioning

confidence: 99%

Biological and Histopathological Evaluations of Using Ozone Gas in Decontamination of AflatoxinB1 in Wheat Grains

TA¹

2017

MOJT

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Forty eight Sprague-Dawley male rats were divided into six groups including the control group fed standard diet, the group fed on AflatoxinB 1 (AFB 1 ) free wheat treated with ozone gas at 20 ppm for 20 min mixed with standard diet, the group fed on AFB 1 free wheat treated with ozone gas at 40 ppm for 20 min mixed with standard diet, the group fed AFB 1 -contaminated diet (2.5 mg/kg diet), the group fed on AFB 1 -contaminated wheat ozonation at 20 ppm for 20 min mixed with standard diet and the group fed on AFB 1 -contaminated wheat ozonation at 40 ppm for 20 min mixed with standard diet. The results indicated that the animals fed AFB 1 -contaminated diet alone showed a significant decrease in feed intake compared to the control group. Animals fed AFB 1 -contaminated wheat treated with ozone showed a significant improvement in feed intake and body weight compared to group fed AFB 1 -contaminated diet. In addition toanimals fed AFB 1 -contaminated diet (2.5mg/kg diet) untreated for 4 weeks showed a significant increase in levels ofthe biochemical parameters and levels of createnine and uric acid compared to the control group or the groups fed ozone treated wheat alone or the AFB 1 -contaminated wheat treated with ozone gas at 20 and 40 ppm. On the other hand animal fed on AFB 1 -contaminated wheat treated with ozone showed a significant improvement in all tested parameters. The Glutathione reduced (GSH) level decreased in animal feed on AFB 1 -contaminated wheat when compared with the control. Moreover, GSH value in animal feed on contaminated diet after ozonation was related with control group. The histological examination of the liver and kidney tissues showed the animals fed on AFB 1 free diet and treated with ozone showed a significant elimination of the harmful effects in the liver and kidney tissues

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“…Prior studies have focused on quercetin as an anticancer agent, but recent research has shown that isorhamnetin can induce higher cytotoxicity in tumor cells as compared with quercetin (29). For example, it was found that aflatoxin B1-mediated ROS was inhibited significantly by isorhamnetin when compared with quercetin in hepatocellular carcinoma cells (32).…”

mentioning

confidence: 99%

Isorhamnetin Inhibits Proliferation and Invasion and Induces Apoptosis through the Modulation of Peroxisome Proliferator-activated Receptor γ Activation Pathway in Gastric Cancer

Ramachandran

Manu

Shanmugam

et al. 2012

Journal of Biological Chemistry

126

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Inhibitory effects of quercetin on aflatoxin B1-induced hepatic damage in mice

Cited by 100 publications

References 33 publications

Protective Effects of Lactobacillus rhamnosus GG on Aflatoxins-Induced Toxicities in Male Albino Mice

Protective Effects of Lactobacillus rhamnosus GG on Aflatoxins-Induced Toxicities in Male Albino Mice

Biological and Histopathological Evaluations of Using Ozone Gas in Decontamination of AflatoxinB1 in Wheat Grains

Isorhamnetin Inhibits Proliferation and Invasion and Induces Apoptosis through the Modulation of Peroxisome Proliferator-activated Receptor γ Activation Pathway in Gastric Cancer

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