Inhibitory Effects of Isorhamnetin-3-O-.BETA.-D-glucoside from Salicornia herbacea on Rat Lens Aldose Reductase and Sorbitol Accumulation in Streptozotocin-Induced Diabetic Rat Tissues

Lee, Yeon Sil; Lee, Sang‐Hyun; Lee, Hye Seung; Kim, Bak-Kwang; Ohuchi, Kazuo; Shin, Kuk Hyun

doi:10.1248/bpb.28.916

Cited by 93 publications

(51 citation statements)

References 16 publications

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“…Da fração acetato de etila, foram isolados os flavonóides 1, 2 e 3 os quais foram identificados pela análise dos espectros de RMN de 1 H e RMN de 13 C, incluindo as técnicas de DEPT, COSY, HMQC e HMBC e por comparação com os dados espectrais relatados na literatura: para quercetina 3-O-β-D-glicosídeo (1) (Melos et al, 2007); isoraminetina 3-glicosídeo (2) (Lee et al, 2005) e quercetina 3-O-soforosídeo (3) (Tang et al, 2007;Price et al, 1998). Não foi possível o isolamento de compostos da fração metanólica.…”

Section: Resultsunclassified

“…A quercetina 3-O-β-D-glicosídeo foi isolada de Prangos ferulaceae (Apiaceae) (Razavi et al, 2009), Euphorbia retusa (Euphorbiaceae) (Harraz, 2009), Rosa nutkana (Rosaceae) (Jovel et al, 2007) e de Desmostachia bipinnata (Gramineae) (Awaad et al, 2008). A quercetina 3-Osoforosídeo também está presente em Pterogyne nitens (Caesalpinioideae) (Regasini et al, 2008) e Bassia muricata (Chenopodiaceae) (Kamel et al, 2001), enquanto que das espécies Salicornia herbacea (Chenopodiaceae) (Lee et al, 2005) e Astragalus corniculatus (Fabaceae) (Krasteva et al, 2008) já foi isolada a isoraminetina 3-glicosídeo.…”

Section: Resultsunclassified

“…Recentemente, Razavi e colaboradores (2009) comprovaram que o composto quercetina 3-O-β-D-glicosídeo apresenta elevado potencial antioxidante e fitotóxico. Em trabalho realizado com Salicornia herbacea, resultados indicaram que a isoraminetina 3-glicosídeo é um composto propício para ser estudado como um novo medicamento para tratamento ou prevenção da diabetes (Lee et al, 2005).…”

Section: Resultsunclassified

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Flavonoides e atividade antioxidante em Palicourea rigida Kunth, Rubiaceae

Rosa¹,

Silva²,

Silva³

et al. 2010

Rev. bras. farmacogn.

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RESUMO:A atividade antioxidante, avaliada pelo método DPPH (1,1-difenil-2-picrilidrazila), e o teor em compostos fenólicos totais do extrato bruto metanólico e frações das folhas da espécie Palicourea rigida Kunth, Rubiaceae, foram quantificadas neste trabalho. Apesar da baixa atividade apresentada pelo extrato bruto (500 ppm), a fração acetato de etila apresentou atividade moderada (192 ppm) e o maior teor de fenólicos totais dentre as frações ensaiadas. Assim, a fração acetato de etila foi submetida a procedimentos cromatográficos o que resultou no isolamento dos flavonoides quercetina 3-O-β-D-glicosídeo, quercetina 3-O-soforosídeo e isoraminetina 3-glicosídeo, cujas estruturas foram elucidadas por análise espectroscópica, incluindo RMN (1D e 2D) e comparação com os dados da literatura.Unitermos: Rubiaceae, Palicourea, flavonoides, atividade antioxidante.ABSTRACT: "Flavonoids and antioxidant activity in Palicourea rigida Kunth, Rubiaceae". The antioxidant activity, evaluated by DPPH (1,1-difenil-2-picrilidrazila) method, and the determination of the total phenolic compounds of the crude methanolic extract and fractions of the Palicourea rigida Kunth, Rubiaceae, leaves were quantified in this work. Despite weak activity exhibited by crude extract (500 ppm), the fraction ethyl acetate showed moderate activity (192 ppm), and the largest value for the phenolic compounds among all the assayed fractions. Then, the ethyl acetate fraction was submitted to the chromatography procedures which led to the isolation of the flavonoid quercetin 3-O-D-glicoside, quercetin 3-O-sophoroside and isorhamnetin 3-glicoside, which had the structures elucidated by spectroscopy analysis, including RMN (1D and 2D) and comparison with literature data.

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Section: Resultsunclassified

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Flavonoides e atividade antioxidante em Palicourea rigida Kunth, Rubiaceae

Rosa¹,

Silva²,

Silva³

et al. 2010

Rev. bras. farmacogn.

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“…Tungtungmadic acid (3-caffeoyl-4-dihydrocaffeoyl quinic acid), β-sitosterol, stigmasterol, uracil, quercetin 3-O-β-D-glucopyranoside, and isorhamnetin 3-O-β-D-glucopyranoside, were isolated from the methanol extract of S. herbacea (Kim and Park, 2004;Lee et al, 2004;Chung et al, 2005;Lee et al, 2005;Kim et al, 2011b). These compounds were recognized as important active ingredients in S. herbacea.…”

Section: Introductionmentioning

confidence: 99%

Effects of <i>Salicornia herbacea</i> on Growth Performance, Meat Quality, Excreta Microbial Populations, and Noxious Gas Emissions in Broiler Chicks

et al. 2019

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ABSTRACT:The current study was conducted to evaluate the effects of adding Salicornia herbacea extracts to the drinking water on the growth performance, meat quality, excreta microbial population, and noxious gas emission in broiler chicks. A total of 544 one-day-old broiler chicks (Ross 308) were used in a 35-d experiment. Broiler chicks were allocated to four treatments with eight replicates, based on a completely randomized design. Diet was the same for all treatments, but a liquid phytogenic supplementation using different quantities of S. herbacea was provided in the drinking compared with the broilers in the CON group (P < 0.05), but broilers supplemented with S. herbacea extracts had a lower feed conversion ratio (FCR) when compared with broilers in the CON group (P < 0.05). Supplementation with S. herbacea extracts had linear effects on the abdominal fat and the redness (a*) of meat (P < 0.05). There were no significant differences between excreta microbial populations and excreta noxious gas emissions in broilers in the CON group, or broilers supplemented with S. herbacea extracts. In conclusion, the results of this study demonstrate that S. herbacea supplementation positively affected the growth performance and meat quality in broilers, indicating that S. herbacea can be safely used to replace antibiotic as a growth promoter, thereby reducing the risk of antibiotic resistance issues.

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“…ALR2 is the first and rate-limiting enzyme in polyol pathway, therefore, it is considered as an important potential therapeutic against diabetes chronic complications (11)(12)(13). A number of ALR2 inhibitors (ARI) have shown the potency of attenuation or prevention of diabetes chronic complications in animal models (14,15), and some of them have been investigated in clinical trials (16,17), but yet most of them have limited success and some of them have severe side effects and low target penetrating (13,(18)(19)(20). The most current classes of synthetic ARI evaluated in phase-III trials are carboxylic acid inhibitors (zopolrestat, ponalrestat and tolerestat) and spiroimide inhibitors (sorbinil); the former have shown low target permeability and are not efficacious in vivo and the latter although have better target penetrating ability but, have shown skin reaction and liver toxicity (15,21,22).…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Aldose Reductase and Sorbitol Accumulation by Hydroalcoholic Extract of Propolis

Aberomand

Parvank

Mohammadzadeh

et al. 2016

Jundishapur J Nat Pharm Prod

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Background: Increased polyol pathway activity and subsequent occurrences, and particular sorbitol accumulation are noticed in the development of various secondary complications of diabetes. Aldose reductase (ALR2) or aldo-ketoreductase (AKR1B1) as the first and rate limiting enzyme of this pathway is a good target for new drugs for diabetes complications. A good inhibitor should inhibit aldehyde reductase (ALR1), the other member of this family lesser than ALR2. Bee propolis is a known substance in ancient medicine, but its effect on polyol pathway is unknown. Objectives: The current study aimed to investigate the effect of hydroalcoholic extract of propolis (HAEP) on partial purified bovine lens ALR2, also the effect of HAEP on sorbitol accumulation in human erythrocytes in high-glucose condition (ex vivo). Materials and Methods: Total protein was determined by lowery method. Bovine lens ALR2 was partially purified by gel filtration chromatography on sephadexTM G25. Bovine cortex kidney ALR1 was partially purified by diethylaminoethyl (DEAE) precipitation. The hydroalcoholic extract was obtained from frozen propolis. The enzyme activity and sorbitol accumulation in erythrocytes were determined spectroflourimetrically. Results: It was found that ethyl acetate (EthAc) fraction (the more potent fraction) of HAEP inhibited ALR2 by IC50 value of 1.12 mg/mL up to 50% and this fraction can inhibit ALR2 8.25-fold greater than ALR1. In addition, it was found that this fraction could decrease sorbitol accumulation in human erythrocytes under high-glucose condition. Conclusions:The obtained results indicated that propolis may be a good candidate for more studies to find new drugs for the treatment of secondary complications of diabetes.

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Inhibitory Effects of Isorhamnetin-3-O-.BETA.-D-glucoside from Salicornia herbacea on Rat Lens Aldose Reductase and Sorbitol Accumulation in Streptozotocin-Induced Diabetic Rat Tissues

Cited by 93 publications

References 16 publications

Flavonoides e atividade antioxidante em Palicourea rigida Kunth, Rubiaceae

Flavonoides e atividade antioxidante em Palicourea rigida Kunth, Rubiaceae

Effects of <i>Salicornia herbacea</i> on Growth Performance, Meat Quality, Excreta Microbial Populations, and Noxious Gas Emissions in Broiler Chicks

Inhibition of Aldose Reductase and Sorbitol Accumulation by Hydroalcoholic Extract of Propolis

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