Inhibitory Effects of Fusarenon on Multiplication of Tetrahymena Pyriformis

Nakano, Naoko

doi:10.7883/yoken1952.21.351

Cited by 6 publications

(2 citation statements)

References 12 publications

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“…Similar effects were obserVed in protozoan cultures (6). The general conclusion from the work reported here, namely that the trichothecenes are inhibitors of eukaryotic protein synthesis, was established directly by Ueno and colleagues (7) (12) at 370 with orbital shaking in glassware treated with Siliclad (ClayAdams, Parsippany, N.J.).…”

supporting

confidence: 79%

Mechanism of Inhibition of Eukaryotic Protein Synthesis by Trichothecene Fungal Toxins

Cundliffe

Cannon

Davies

1974

Proc. Natl. Acad. Sci. U.S.A.

204

120

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supporting

confidence: 79%

Mechanism of Inhibition of Eukaryotic Protein Synthesis by Trichothecene Fungal Toxins

Cundliffe

Cannon

Davies

1974

Proc. Natl. Acad. Sci. U.S.A.

204

120

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“…New Zealand). Type A trichothecenes are more toxic than type B trichothecenes (Leeson et al 1995;Nakano 1968;Ueno and Yamakawa 1970). This was also observed among the trichothecene-producing isolates in Western Australia, where 5 μg ml -1 of crude fungal extracts from type A trichothecene-producing isolates killed almost 100% of the brine shrimp, while those of the type B trichotheceneproducing isolates killed approximately 1% in 48 h.…”

Section: Discussionmentioning

confidence: 99%

Mycotoxins produced by Fusarium species associated with annual legume pastures and ‘sheep feed refusal disorders’ in Western Australia

et al. 2011

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Sheep grazing in Western Australia can partially or completely refuse to consume annual Medicago pods contaminated with a number of different Fusarium species. Many Fusarium species are known to produce trichothecenes as part of their array of toxigenic secondary metabolites, which are known to cause feed refusal in animals. This study reports the identity of Fusarium species using species-specific PCR primers and a characterization of the toxigenic secondary metabolites produced by 24 Fusarium isolates associated with annual legume-based pastures and particularly those associated with sheep feed refusal disorders in Western Australia. Purification of the fungal extracts was facilitated by a bioassay-guided fractionation using brine shrimp. A number of trichothecenes (3-acetyldeoxynivalenol, deoxynivalenol, fusarenon-X, monoacetoxyscirpenols, diacetoxyscirpenol, scirpentriol, HT-2 toxin and T-2 toxin), enniatins (A, A1, B, and B1), chlamydosporol and zearalenone were identified using GC/MS and/or NMR spectroscopy. Some of the crude extracts and fractions showed significant activity against brine shrimp at concentrations as low as 5 μg ml(-1), and are likely to be involved in the sheep feed refusal disorders. This is the first report of chlamydosporol production by confirmed Fusarium spp.; of the incidence of F. brachygibbosum and F. venenatum in Australia and of F. tricinctum in Western Australia; and of mycotoxin production by Fusarium species from Western Australia.

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Polyribosomal breakdown in mouse fibroblasts (L-cells) by fusarenox-X, a toxic principle isolated from Fusarium nivale

Ohtsubo

Kaden

Mittermayer

1972

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein

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Inhibitory Effects of Fusarenon on Multiplication of Tetrahymena Pyriformis

Cited by 6 publications

References 12 publications

Mechanism of Inhibition of Eukaryotic Protein Synthesis by Trichothecene Fungal Toxins

Mechanism of Inhibition of Eukaryotic Protein Synthesis by Trichothecene Fungal Toxins

Mycotoxins produced by Fusarium species associated with annual legume pastures and ‘sheep feed refusal disorders’ in Western Australia

Polyribosomal breakdown in mouse fibroblasts (L-cells) by fusarenox-X, a toxic principle isolated from Fusarium nivale

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