Inhibitory Effects of Citrus Flavonoids on Starch Digestion and Antihyperglycemic Effects in HepG2 Cells

Shen, Wei; Xu, Ying; Lü, Yanhua

doi:10.1021/jf3032556

Cited by 122 publications

(91 citation statements)

References 50 publications

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“…In fact, many phenolic compounds and specially flavonoids have been reported as potential antidiabetic agents because they exert a good inhibitory action against α-amylase and could have potential prevention in diabetes mellitus as part of a dietary strategy [49]. These results were confirmed by others studies which showed that all of the tested Citrus flavonoids significantly inhibited amylase-catalyzed starch digestion [50]. Natural alpha-amylase inhibitors offer an attractive approach to the management of postprandial hyperglycemia by decreasing glucose release from starch [51].…”

Section: Inhibition Of α-Amylase Activitysupporting

confidence: 54%

Evaluation of In-vitro Antidiabetic and Hypolipidaemic Activities of Extracts Citrus Lemon Fruit

Basli¹,

Younici²,

Benkerrou³

et al. 2016

JESE-A

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Citrus genus is the most important fruit tree crop in the world and lemon is the third most important Citrus species. The evaluation of the potential inhibitory activity on α-amylase and pancreatic lipase by Citrus lemon fruits of Algerian origin aiming for new applications of the fruits in nutrition and health was carried out. Lemon fruit EtOAc (ethyl acetate) extract showed higher contents of phytochemicals such as total phenolics and flavonoids. Furthermore, lemon fruit showed higher potential for inhibitory effects on α-amylase and pancreatic lipase. It could be concluded that lemon fruits are of great value for nutrition and treatment of diet-related diseases such as obesity and diabetes.

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Section: Inhibition Of α-Amylase Activitysupporting

confidence: 54%

Evaluation of In-vitro Antidiabetic and Hypolipidaemic Activities of Extracts Citrus Lemon Fruit

Basli¹,

Younici²,

Benkerrou³

et al. 2016

JESE-A

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“…Second, we observed that NRG could exert remarkable antihyperglycemic effects (Table 1) in STZ-induced diabetic rats. Its mechanism has multiple components: (i) NRG activates glutathione (GSH) synthesis through a novel antioxidant defense mechanism against excessive ROS production, which contributes to the prevention of oxidative damage in addition to its effect on glycemic control (Dhanya et al 2015); (ii) NRG plays important roles in preventing the progression of hyperglycemia, partly by binding to starch by increasing hepatic glycolysis and the glycogen concentration and lowering hepatic gluconeogenesis (Shen et al 2012); (iii) NRG exhibits antidiabetic effects in a rat model of type 2 diabetes mellitus (T2DM) by potentiating the antioxidant defense system and suppressing pro-inflammatory cytokine production (Mahmoud et al 2012). Third, this study demonstrates the inhibitory effect of NRG on myocardial remodeling and cardiac fibrosis in STZinduced diabetic rats by inhibiting the NF-κB pathway.…”

Section: Discussionmentioning

confidence: 99%

Naringin protects cardiomyocytes against hyperglycemia-induced injuries in vitro and in vivo

Qin

et al. 2016

Journal of Endocrinology

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We previously reported that naringin (NRG) protects cardiomyocytes against high glucose (HG)-induced injuries by inhibiting the MAPK pathway. The aim of this study was to test the hypothesis that NRG prevents cardiomyocytes from hyperglycemia-induced insult through the inhibition of the nuclear factor kappa B (NF-κB) pathway and the upregulation of ATP-sensitive K + (K ATP ) channels. Our results showed that exposure of cardiomyocytes to HG for 24 h markedly induced injuries, as evidenced by a decrease in cell viability and oxidative stress, and increases in apoptotic cells as well as the dissipation of mitochondrial membrane potential (MMP). These injuries were markedly attenuated by the pretreatment of cells with either NRG or pyrrolidine dithiocarbamate (PDTC) before exposure to HG. Furthermore, in streptozotocin (STZ)-induced diabetic rats and in HG-induced cardiomyocytes, the expression levels of caspase-3, bax and phosphorylated (p)-NF-κB p65 were increased. The increased protein levels were ameliorated by pretreatment with both NRG and PDTC. However, the expression levels of bcl-2 and K ATP and superoxide dismutase (SOD) activity were decreased by hyperglycemia; the expression level of Nox4 and the ADP/ATP ratio were increased by hyperglycemia. These hyperglycemia-induced indexes were inhibited by the pretreatment of cardiomyocytes with NRG or PDTC. In addition, in STZ-induced diabetic rats, we also observed that NRG or PDTC contributed to protecting mitochondrial injury and myocardium damage. This study demonstrated that NRG protects cardiomyocytes against hyperglycemia-induced injury by upregulating K ATP channels in vitro and inhibiting the NF-κB pathway in vivo and in vitro.

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“…In addition, plants from this genus have been extensively studied for their antimicrobial, antioxidant, anti-infl ammatory, antiedemic, cardiovascular, antihyperglycaemic, and antitumour properties (Johann et al, 2007;Benavente-Garcia and Castillo, 2008;Fisher and Phillips, 2008;Shen et al, 2012;Mencherini et al, 2013;Wesołowska et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition of the Essential Oils of Variegated Pink-Fleshed Lemon (Citrus x limon L. Burm. f.) and their Anti-Inflammatory and Antimicrobial Activities

Hamdan

Ashour

Mulyaningsih

et al. 2013

Zeitschrift Für Naturforschung C

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The volatile secondary metabolites of essential oils from fruit peel and leaves of variegated pink-fl eshed lemon (Citrus x limon) were investigated using GLC and GLC-MS (gas-liquid chromatography-mass spectroscopy). Altogether 141 compounds were identifi ed and quantifi ed, accounting for 99.59% and 96.33% of the total hydrodistilled peel and leaf oil, respectively. Limonene occurred in higher amounts in fruit peel (52.73%) than in leaf oil (29.13%). Neral (12.72%), neryl acetate (8.53%), ρ-menth-1-en-7-al (4.63%), β-pinene (6.35%), and nerol (4.42%) were the most abundant constituents in leaf oil, whereas γ-terpinene (9.88%), β-pinene (7.67%), geranial (4.44%), and neral (3.64%) dominated in the fruit peel oil. The antioxidant, anti-infl ammatory, antitrypanosomal, and antimicrobial activities of the fruit peel essential oil were evaluated. The oil had a low antioxidant activity with an IC 50 value of (26.66 ± 2.07) mg/ml as compared to the effi cient antioxidant ascorbic acid [IC 50 (16.32 ± 0.16) μg/ml]. The oil moderately inhibited soybean 5-lipoxygenase (5-LOX) with an IC 50 value of (32.05 ± 3.91) μg/ml and had moderate antitrypanosomal activity [IC 50 (60.90 ± 0.91) μg/ml]. In addition, moderate antimicrobial activities were detected against Gram-positive bacteria (Bacillus subtilis, Staphylococcus capitis, Micrococcus luteus), one Gram-negative bacterium (Pseudomonas fl uorescens), and yeasts (Saccharomyces cerevisiae, Candida parapsilosis).

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Inhibitory Effects of Citrus Flavonoids on Starch Digestion and Antihyperglycemic Effects in HepG2 Cells

Cited by 122 publications

References 50 publications

Evaluation of In-vitro Antidiabetic and Hypolipidaemic Activities of Extracts Citrus Lemon Fruit

Evaluation of In-vitro Antidiabetic and Hypolipidaemic Activities of Extracts Citrus Lemon Fruit

Naringin protects cardiomyocytes against hyperglycemia-induced injuries in vitro and in vivo

Chemical Composition of the Essential Oils of Variegated Pink-Fleshed Lemon (Citrus x limon L. Burm. f.) and their Anti-Inflammatory and Antimicrobial Activities

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