Inhibitory effects of chestnut inner skin extracts on melanogenesis

Kim, Ji Hye; Choi, Gi Jun; Kwak, Ji Hyun; Jeong, Chang-Ho; Jeong, Hee Rok; Lee, Uk; Kim, Man-Jo; Heo, Ho Jin

doi:10.1007/s10068-012-0209-8

Cited by 14 publications

(15 citation statements)

References 26 publications

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“…The chestnut ( Castanea crenata ) inner shell has long been used in Korea as a medicinal herb for improving digestion and as an anti‐ageing and anti‐wrinkle ingredient in cosmetic preparations . Chestnut ethanol extracts have presented anticancer effects against gastric cancer cells .…”

Section: Introductionmentioning

confidence: 99%

Comparative analysis of the antioxidant and anticancer activities of chestnut inner shell extracts prepared with various solvents

Jung

Lee

et al. 2015

J Sci Food Agric

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BACKGROUND The chestnut inner shell (CIS) has long been used as a medicinal herb for strengthening the antioxidant in the cosmetic industry. However, little is known about the antioxidant and anticancer effects of the CIS. RESULTS The antioxidant and anticancer effects of CIS extracts (CISEs) were investigated by the use of various methods and cancer cell lines, respectively. The total polyphenol content of CISEs using ethanol, methanol, butanol, ethyl acetate and water were 53.30, 43.98, 32.16, 26.79 and 11.53 mg gallic acid equivalents g−1, respectively. The CISEs using ethanol and methanol exhibited high antioxidant activities in the 1,1‐diphenyl‐2‐picrylhydrazyl radical scavenging activity, β‐carotene bleaching and ferric reducing ability of plasma assays; the effects were equivalent to those of butylated hydroxytoluene. All CISEs at 2.5 mg mL−1 were shown to have a cytotoxic effect over 50%, and the CISE using ethyl acetate at 0.6 mg mL−1 was proved to have 90% cytotoxic effect against the tested cancer cells. CONCLUSION The ethanol and methanol CISEs had potent antioxidant effects, and the ethyl acetate CISE had the highest cytotoxicity. These results suggest that CISEs could be used as functional ingredients for antioxidant and anticancer effects in foods as extraction solvents. © 2015 Society of Chemical Industry

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Section: Introductionmentioning

confidence: 99%

Comparative analysis of the antioxidant and anticancer activities of chestnut inner shell extracts prepared with various solvents

Jung

Lee

et al. 2015

J Sci Food Agric

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“…On the other hand, Glechoma hederacea L. and Castanea flower extracts inhibited TYR activity and MITF protein expression but not inhibited TRP1 and TRP2 protein expression in melanocytes and SK‐MEL‐2 cells . These two extracts may contain several bioactive compounds, in which some of them may have an antagonist effect.…”

Section: Depigmenting Compounds and Their Modulation On Melanogenesismentioning

confidence: 95%

“…Other compounds such as 3,4‐dihydroquinazoline‐2(1H)‐thiones (C 16 H 15 N 2 S) and isosilybins A (C 25 H 22 O 10 ) as well as plant extract (ie, Pini Nodi Lignum, Glechoma hederacea L., Gaillardia aristata, Melissa officinalis , Alpinia galangal , Curcuma aromatic , Alpinia officinarum , and other herb extracts) showed significant higher depigmenting activity as compared to KA and arbutin . The 3,4‐dihydroquinazoline‐2(1H)‐thiones remarkably reduced α‐MSH‐stimulated melanin synthesis in B16 cell lines without inhibiting the catalytic activity of TYR .…”

Section: Depigmenting Compounds and Their Modulation On Melanogenesismentioning

confidence: 99%

“…Several depigmenting compounds showed antimelanogenic activity via ERK‐mediated downregulation of MITF. For instance, Eucalyptus camaldulensis flower EO, Artocarpus communis extracts, geranylgeranylacetone (C 23 H 37 O), menadione (C 11 H 8 O 2 ), β‐lapachone (C 15 H 14 O 3 ), fucoidan, Withania somnifer, dipeptides (proline‐serine [C 8 H 16 O 5 N 2 ] and valine‐serine [C 8 H 18 O 5 N 2 ]) inhibit melanogenesis through downregulating of MITF via ERK signaling pathways as demonstrated using various cell line models (ie, B16F10, Mel‐Ab cells, human epidermal equivalents [HEE], and Melanoderm™) . E camaldulensis EO and aglycone of Rh 4 differ from other depigmenting compounds in which they also downregulate protein kinase A (PKA) where E camaldulensis EO but not aglycone of Rh 4 also regulates mitogen‐activated protein kinases p38 (p38 MAPK) .…”

Section: Depigmenting Compounds and Their Modulation On Melanogenesismentioning

confidence: 99%

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Discovery of new depigmenting compounds and their efficacy to treat hyperpigmentation: Evidence from in vitro study

Lajis

Ariff

2019

J of Cosmetic Dermatology

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Summary Human skin pigmentation is a result of constitutive and facultative pigmentation. Facultative pigmentation is frequently stimulated by UV radiation, pharmacologic drugs, and hormones whereby leads to the development of abnormal skin hyperpigmentation. To date, many state‐of‐art depigmenting compounds have been studied using in vitro model to treat hyperpigmentation problems for cosmetic dermatological applications; little attention has been made to compare the effectiveness of these depigmenting compounds and their mode of actions. In this present article, new and recent depigmenting compounds, their melanogenic pathway targets, and modes of action are reviewed. This article compares the effectiveness of these new depigmenting compounds to modulate several melanogenesis‐regulatory enzymes and proteins such as tyrosinase (TYR), TYR‐related protein‐1 (TRP1), TYR‐related protein‐2 (TRP2), microphthalmia‐associated transcription factor (MITF), extracellular signal—regulated kinase (ERK) and N‐terminal kinases (JNK) and mitogen‐activated protein kinase p38 (p38 MAPK). Other evidences from in vitro assays such as inhibition on melanosomal transfer, proteasomes, nitric oxide, and inflammation‐induced melanogenesis are also highlighted. This article also reviews analytical techniques in different assays performed using in vitro model as well as their advantages and limitations. This article also provides an insight on recent finding and re‐examination of some protocols as well as their effectiveness and reliability in the evaluation of depigmenting compounds. Evidence and support from related patents are also incorporated in this present article to give an overview on current patented technology, latest trends, and intellectual values of some depigmenting compounds and protocols, which are rarely highlighted in the literatures.

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“…The fruit and leaves of chestnut are rich in polyphenolics [13]. Recent data showed that tannin is relatively abundant in chestnut inner shell extract [14], and chestnut endothelial extract may have the potential to inhibit melanin biosynthesis [15]. However, the anti-melanogenic potential of chestnut husk has not yet been elucidated.…”

mentioning

confidence: 99%

Anti-Melanogenic Effect of Chestnut Spike Extract through Downregulation of Tyrosinase-Related Proteins and Activation of ERK 1/2

Byeon

Alam

Kim

et al. 2018

Natural Product Communications

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Melanin has been reported to be the key factor for skin homeostasis. Besides defining an important human phenotypic trait, melanin overproduction may cause various disorders such as vitiligo, Addison's disease, Cushing's syndrome, and melasma. In this study, we aimed to investigate the anti-melanogenic potential of dried spike extract of chestnut. The extract inhibited tyrosinase (TYR) activity in a dose-dependent manner. Cellular melanin content decreased markedly after treatment with the extract. The spike extract inhibited microphthalmia-associated transcription factor (MITF) expression and downregulated TYR, TYRP-1, and TYRP-2 protein expression by increasing the phosphorylation of extracellular signal-regulated kinase (ERK)1/2 signalling pathway in melan-a cells. In addition, treatment with U0126, a specific inhibitor of ERK, restored melanin content. Collectively, these results suggest that the chestnut spike extract attenuated melanogenesis by inhibiting MITF expression and downregulating TYR, TYRP-1, and TYRP-2 protein expressions via activation of ERK1/2 pathway.

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Inhibitory effects of chestnut inner skin extracts on melanogenesis

Cited by 14 publications

References 26 publications

Comparative analysis of the antioxidant and anticancer activities of chestnut inner shell extracts prepared with various solvents

Comparative analysis of the antioxidant and anticancer activities of chestnut inner shell extracts prepared with various solvents

Discovery of new depigmenting compounds and their efficacy to treat hyperpigmentation: Evidence from in vitro study

Anti-Melanogenic Effect of Chestnut Spike Extract through Downregulation of Tyrosinase-Related Proteins and Activation of ERK 1/2

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