2012
DOI: 10.1007/s10616-012-9457-y View full text |Buy / Rent full text
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Abstract: In this study, the anti-allergy potency of thirteen tannins isolated from the galls on buds of Carpinus tschonoskii (including two tannin derivatives) was investigated. RBL-2H3 (rat basophilic leukemia) cells were incubated with these compounds, and the release of b-hexosaminidase and cytotoxicity were measured. Of the thirteen tannins, tetragalloylglucose (2), pentagalloylglucose (3), casuarictin (4), and casuarinin (9) were the most potent inhibitors, and all the tannins showed no cytotoxic effect after 24 h… Show more

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“…Casu isolated from different plant species such as Carpinus tschonoskii and strawberry is able to inhibit allergic reactions induced by BSA (bovine serum albumin) and leads to NF-kβ inhibition, exerting a gastric anti-inflammatory function [24,25]. However, the evaluation of Casu anti-inflammatory activity in the presence of sPLA2 as a pro-inflammatory agent is essential considering the fundamental role of this enzyme in the inflammatory process [26].…”
Section: Discussionmentioning
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“…Casu isolated from different plant species such as Carpinus tschonoskii and strawberry is able to inhibit allergic reactions induced by BSA (bovine serum albumin) and leads to NF-kβ inhibition, exerting a gastric anti-inflammatory function [24,25]. However, the evaluation of Casu anti-inflammatory activity in the presence of sPLA2 as a pro-inflammatory agent is essential considering the fundamental role of this enzyme in the inflammatory process [26].…”
Section: Discussionmentioning
“…26 TA is an exogenous substance suggested to be capable of inhibiting allergic reactions and which might be useful for the treatment or prevention of type I allergic diseases. 27 However it is also suspected to be an anaphylactoid potential allergen 28 which can cause significant anaphylactoid reaction when used in high concentration as demonstrated in our study. C48/80 is a well-known activator of mast cells via phospholipase D and heterotrimeric GTPbinding proteins.…”
Section: Discussionmentioning
“…Previous studies have reported the effect of condensed tannins on compound 48/80-induced mast cell degranulation (Tokura et al, 2005) and on histamine release from RBL cells (Kanda et al, 1998). Apart from these, tannins were also able to suppress the release of β-hexosaminidase from RBL-2H3 cells after trigger by IgE (Yamada et al, 2012). Considering the abundance of tannins in AEBv, it is possible that the antiallergenic activity exerted by this extract might to be associated with this class of metabolites.…”
Section: Discussionmentioning