Inhibitory Effect of Gallic Acid and Its Esters on 2,2′-Azobis(2-amidinopropane)hydrochloride (AAPH)-Induced Hemolysis and Depletion of Intracellular Glutathione in Erythrocytes

Ximenes, Valdecir Farias; Lopes, Mariana Garcia Mendonça; Petrônio, Maicon Segalla; Regasini, Luís Octávio; Silva, Dulce Helena Siqueira; Fonseca, Luiz Marcos da

doi:10.1021/jf100233y

Cited by 50 publications

(38 citation statements)

References 42 publications

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“…The crude products were purified over a silica gel column eluted with mixtures of hexanes and EtOAc, furnishing alkyl gallates (compounds 2 to 16) ( Table 1). The molecular structures of these compounds were established by 1 H and 13 C nuclear magnetic resonance (NMR) spectral analysis (16,17).…”

Section: Methodsmentioning

confidence: 99%

“…Synthetic esters of gallic acid were prepared as described previously, with minor modifications (16,17). A 3.0-ml solution of N,N=-dicyclohexylcarbodiimide (DCC) (1.0 mmol) in dried p-dioxane was added to a cooled (5°C) solution of 0.2 mmol gallic acid (Sigma) (compound 1) (Table 1) and 20 mmol alkyl alcohol in 6.0 ml of dried p-dioxane.…”

Section: Methodsmentioning

confidence: 99%

“…citri subsp. citri activity of gallic acid (3,4,5-trihydroxybenzoic acid), an intermediate of the hydrolysable tannin biosynthesis pathway in plants ( [13][14][15] which, together with its natural and semisynthetic derivatives, has been associated with a broad spectrum of biological actions (16)(17)(18)(19)(20)(21). Moreover, gallic acid and derivatives demonstrated antimicrobial properties.…”

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Antibacterial Activity of Alkyl Gallates against Xanthomonas citri subsp. citri

et al. 2013

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The plant-pathogenic bacterium Xanthomonas citri subsp. citri is the causal agent of Asiatic citrus canker, a serious disease that affects all the cultivars of citrus in subtropical citrus-producing areas worldwide. There is no curative treatment for citrus canker; thus, the eradication of infected plants constitutes the only effective control of the spread of X. citri subsp. citri. Since the eradication program in the state of São Paulo, Brazil, is under threat, there is a clear risk of X. citri subsp. citri becoming endemic in the main orange-producing area in the world. Here we evaluated the potential use of alkyl gallates to prevent X. citri subsp. citri growth. These esters displayed a potent anti-X. citri subsp. citri activity similar to that of kanamycin (positive control), as evaluated by the resazurin microtiter assay (REMA). The treatment of X. citri subsp. citri cells with these compounds induced altered cell morphology, and investigations of the possible intracellular targets using X. citri subsp. citri strains labeled for the septum and centromere pointed to a common target involved in chromosome segregation and cell division. Finally, the artificial inoculation of citrus with X. citri subsp. citri cells pretreated with alkyl gallates showed that the bacterium loses the ability to colonize its host, which indicates the potential of these esters to protect citrus plants against X. citri subsp. citri infection.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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confidence: 99%

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Antibacterial Activity of Alkyl Gallates against Xanthomonas citri subsp. citri

et al. 2013

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“…Hsieh et al (28) found that, under in vitro conditions, gallic acid protected human erythrocytes from oxidative damage. In contradiction to this fi nding, Ximenes et al (29) suggested that gallic acid is prooxidative in cellular systems and could exacerbate the drug-induced prooxidative damage in human erythrocytes. The prooxidative effect of gallic acid at the molecular level (30) and oxidative-based induction of cell death in cancer cells (31,32) have also been documented.…”

Section: Resultsmentioning

confidence: 87%

In Vivo Protective Effects of Gallic Acid Isolated from Peltiphyllum Peltatum Against Sodium Fluoride-Induced Oxidative Stress in Rat Erythrocytes

Nabavi

Habtemariam

Sureda

et al. 2013

Archives of Industrial Hygiene and Toxicology

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Gallic acid has been identifi ed as an antioxidant component of the edible and medicinal plant Peltiphyllum peltatum. The present study examined its potential protective role against sodium fl uoride (NaF)-induced oxidative stress in rat erythrocytes. Oxidative stress was induced by NaF administration through drinking water (1030.675 mg m -3 for one week). Gallic acid at 10 mg kg -1 and 20 mg kg -1 and vitamin C for positive controls (10 mg kg -1 ) were administered daily intraperitoneally for one week prior to NaF administration. Thiobarbituric acid reactive substances, antioxidant enzyme activities (superoxide dismutase and catalase), and the level of reduced glutathione were evaluated in rat erythrocytes. Lipid peroxidation in NaF-exposed rats signifi cantly increased (by 88.8 %) when compared to the control group (p<0.05). Pre-treatment with gallic acid suppressed lipid peroxidation in erythrocytes in a dose-dependent manner. Catalase and superoxide dismutase enzyme activities and glutathione levels were reduced by NaF intoxication by 54.4 %, 63.69 %, and 42 % (p<0.001; vs. untreated control group), respectively. Pre-treatment with gallic acid or vitamin C signifi cantly attenuated the deleterious effects. Gallic acid isolated from Peltiphyllum peltatum and vitamin C mitigated the NaF-induced oxidative stress in rat erythrocytes.

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“…However, its effect to inhibit inflammatory activity still could not be omitted. It was previously reported that gallic acid in TC to possessed anti-inflammatory (Ximenes et al, 2010). Unfortunately, this study did not investigate about the possible active ingredients and the precise underlying mechanisms of this extract could attenuate memory impairment; this is planned in future studies.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Neuropharmacological Activities of <i>Terminalia Chebula</i> in Rats

A.¹

2012

American Journal of Pharmacology and Toxicology

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Problem statement:Oxidative stress has been implicated in the pathophysiology of many neurodegenerative diseases such as Alzheimer's Disease (AD). In traditional practices of Ayurvedic medicine, numerous herbs have been used to treat cognitive disorders. Terminalia Chebula (Combretaceae; TC), is a well-known Ayurvedic herbal remedy which possesses an antioxidant activity. The scientific literature strongly supports its in vitro exerted acetylcholinesterase inhibitory and has suggested developing this herb as a potential in the treatment of AD, However, the in vivo neurophamacological activities of this plant have never been studied. Approach: Adult male SpragueDawley rats were orally given the different doses of aqueous extracts of TC (10, 20 and 40 mg kg −1 ) once daily at a period of 2 weeks. The series of established neuropharmacological tests including elevated plus maze, forced swimming, open field and water maze tests were assessed after single administration, 1 and 2 weeks of treatment. Results: TC at a dose of 40 mg kg −1 treated rats exhibited a significant cognitive enhancing effect at all treatment duration. Unfortunately, this substance failed to show dose dependant manner and the other effects. Conclusion: With the above data, it can then be primarily concluded that aqueous extracts of TC should be further investigated about possible active ingredients and developed in line of other anti-Alzheimer herbal drugs or herbal brain booster.

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Inhibitory Effect of Gallic Acid and Its Esters on 2,2′-Azobis(2-amidinopropane)hydrochloride (AAPH)-Induced Hemolysis and Depletion of Intracellular Glutathione in Erythrocytes

Cited by 50 publications

References 42 publications

Antibacterial Activity of Alkyl Gallates against Xanthomonas citri subsp. citri

Antibacterial Activity of Alkyl Gallates against Xanthomonas citri subsp. citri

In Vivo Protective Effects of Gallic Acid Isolated from Peltiphyllum Peltatum Against Sodium Fluoride-Induced Oxidative Stress in Rat Erythrocytes

Assessment of Neuropharmacological Activities of <i>Terminalia Chebula</i> in Rats

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