Inhibitory effect of essential oils against herpes simplex virus type 2

Koch, Christine; Reichling, Jürgen; Schneele, Jürgen; Schnitzler, Paul

doi:10.1016/j.phymed.2007.09.003

Cited by 206 publications

(154 citation statements)

References 39 publications

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“…Moreover, enveloped viruses distinct to flavivirus were also inactivated by treatment with the essential oil obtained from medicinal plants. The in vitro replication abilities of the herpes simplex virus, hepatitis B virus and human immunodeficiency virus were suppressed by the previous exposure to essential oils but not by treatment of the cell with the essential oil before the adsorption of the virus (Zhang et al 1988, siddiqui et al 1996, Yamasaki et al 1998, schuhmacher et al 2003, saddi et al 2007, Koch et al 2008.…”

Section: Resultsmentioning

confidence: 99%

Virucidal activity of Colombian Lippia essential oils on dengue virus replication in vitro

Ocazionez

Meneses

Torres

et al. 2010

Mem. Inst. Oswaldo Cruz

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The inhibitory effect of Lippia alba and Lippia citriodora essential oils on dengue virus serotypes replication in vitro was investigated. The cytotoxicity (CC 50 ) was evaluated by the MTT assay and the mode of viral inhibitory effect was investigated with a plaque reduction assay. The virus was treated with the essential oil for 2 h at 37 o C before cell adsorption and experiments were conducted to evaluate inhibition of untreated-virus replication in the presence of oil. Antiviral activity was defined as the concentration of essential oil that caused 50% reduction of the virus plaque number (IC 50 ). L. alba oil resulted in less cytotoxicity than L. citriodora oil (CC 50 : 139.5 vs. 57.6 µg/mL). Virus plaque reduction for all four dengue serotypes was observed by treatment of the virus before adsorption on cell. The IC 50 values for L. alba oil were between 0. 4-32.6 µg/mL and between 1.9-33.7 µg/mL for L. citriodora oil. No viral inhibitory effect was observed by addition of the essential oil after virus adsorption. The inhibitory effect of the essential oil seems to cause direct virus inactivation before adsorption on host cell.Key words: essential oil -antiviral -virucidal activity -dengue virus -Lippia sp.Dengue is an acute illness characterised by the hemorrhagic fever caused by dengue virus (DENV) that is transmitted to humans by Aedes mosquitoes. DENV infection results in a spectrum of disease ranging from a mild febrile illness or dengue fever to a severe disease or dengue hemorrhagic fever/dengue shock syndrome. Among the human arboviral diseases, dengue is responsible for causing most illness and death. It has been estimated that 50-100 million dengue infections occur each year in tropical urban areas around the world with 20,000-25,000 deaths (Gubler 2006).DENV is a member of the Flaviviridae family and it exists as four related serotypes (DENV-1 2, 3 and 4). The virus possesses an icosahedral nucleocapsid core surrounded by a host-derived lipid membrane (envelope), in which the envelope (E) protein and membrane (M) protein are embedded. The Flavivirus enters into the host cell by receptor-mediated endocytosis into coated vesicles, a process in which the E protein plays the major role. The E protein mediates interactions within the virus and the components of the host cell membrane involved in virus adsorption and the E protein interacts with the membrane cell during fusion (Lindenbach & Rice 2007). Compounds that interact with sites on the E protein that binds to structures on the cellular membrane affect the adsorption and fusion process. That interferes There is no antiviral drug for treatment for any of the Flavivirus and an effective vaccine for human use is not yet available to prevent dengue. Consequently, the development of antiviral drugs licensed for treatment of patients remains an urgent need to prevent dengue fatalities. Compounds obtained from traditional medicinal plants and herbs species have been reported to have antiviral activity and a wide variety of active phytochemicals hav...

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Section: Resultsmentioning

confidence: 99%

Virucidal activity of Colombian Lippia essential oils on dengue virus replication in vitro

Ocazionez

Meneses

Torres

et al. 2010

Mem. Inst. Oswaldo Cruz

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“…Ginger is used as a culinary herb and also as a traditional remedy for various ailments. The essential oil isolated from ginger by steam distillation is known to possess antibacterial, antiviral and antifungal activities (Singh et al, 2005;Koch et al, 2008). It is also reported to have antioxidant, ant-inflammatory, and antinociceptive activity (Vendruscolo et al, 2006;Jeena et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Protection against Whole Body γ-Irradiation Induced Oxidative Stress and Clastogenic Damage in Mice by Ginger Essential Oil

Jeena

Liju²,

Ramanath³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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Radioprotective effects of ginger essential oil (GEO) on mortality, body weight alteration, hematological parameters, antioxidant status and chromosomal damage were studied in irradiated mice. Regression analysis of survival data in mice exposed to radiation yielded LD50/30 as 7.12 and 10.14 Gy for control (irradiation alone) and experimental (GEO-treated irradiated) mice, respectively, with a dose reduction factor (DRF) of 1.42. In mice exposed to whole-body gamma-irradiation (6 Gy), GEO pre-treatment at 100 and 500 mg/kg b.wt (orally) significantly ameliorated decreased hematological and immunological parameters. Radiation induced reduction in intestinal tissue antioxidant enzyme levels such as superoxide dismutase, catalase, glutathione peroxidase and glutathione was also reversed following administration of GEO. Tissue architecture of small intestine which was damaged following irradiation was improved upon administration of GEO. Anticlastogenic effects of GEO were studied by micronuclei assay, chromosomal aberration and alkaline gel electrophoresis assay. GEO significantly decreased the formation of micronuclei, increased the P/N ratio, inhibited the formation of chromosomal aberrations and protected agaisnt cellular DNA damage in bone marrow cells as revealed by comet assay. These results are supportive of use of GEO as a potential radioprotective compound.

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“…Sandalwood is 90% santolol, with some hydrocarbons and aldehydes, thus sandalwood oil was reported exhibit antiviral effect against HSV-1 and HSV-2. [9] www.wjpps.com [27] The anti-influenza A/HK (H3N2) virus activity of β-santalol and evaluated in MDCK cells and explored the effect of β-santalol on synthesis of viral mRNAs. β-Santalol was investigated for its antiviral activity against influenza A/HK (H3N2) virus using a cytopathic effect (CPE) reduction method.…”

Section: Vol 6 Issue 8 2017 669 Soundararajan Et Al World Journalmentioning

confidence: 99%

Recent Developments in Pharmaceutical and Therapeutic Applications of Sandalwood Oil

Soundararajan¹

2017

WJPPS

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Santalum album L is commercially known as the East Indian sandalwood. The average yield of oil ranges from 2-6% w/w of heartwood content. Santalum album L. has been widely used in folk medicine for various ailments like common colds, bronchitis, skin disorders, heart ailments, infection of the urinary tract and other diseases. Since ancient times, sandalwood oil is recognized for its medicinal value and very interesting and powerful natural plant source.Recent pharmacological investigations reveal that the therapeutic potentials associated with Indian sandalwood oil and its constituents such as the role of santalols in combating cancer, viral diseases, as well as neuroleptic, skin nourishing agent and as dietary factors promise future healthcare applications. Sandalwood has been used in traditional medicine system for treating digestive complications arising from diarrhea, nausea, colic and gastritis, muscle relaxant and coolant. It has long been valued for treating these types of genito-urinary infections. Its use in treatment of skin problems is legendary. In the realm of mental and emotional therapeutics, sandalwood is used for treating stress, depression, stress anxiety and nervous tension as it is both a sedative and tonic. Antiviral activity of sandalwood oil against herpes simplex virus, anti-cancer activities, treatment of various eye infections as herbal eye-drop preparation, blood pressure and selfrated arousal like alertness, attentiveness, calmness, mood, relaxation and vigor in humans have been added to latest report. The aim of this review is to comprehend and put forth, available information on the therapeutic uses of Indian sandalwood oil from pharmacological point of view for future directions in clinical applications.

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Inhibitory effect of essential oils against herpes simplex virus type 2

Cited by 206 publications

References 39 publications

Virucidal activity of Colombian Lippia essential oils on dengue virus replication in vitro

Virucidal activity of Colombian Lippia essential oils on dengue virus replication in vitro

Protection against Whole Body γ-Irradiation Induced Oxidative Stress and Clastogenic Damage in Mice by Ginger Essential Oil

Recent Developments in Pharmaceutical and Therapeutic Applications of Sandalwood Oil

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