Inhibitory Effect of Dietary Carotenoids on Dinitrofluorobenzene-Induced Contact Hypersensitivity in Mice

Sakaï, Shota; Sugawara, Tatsuya; Hirata, Takashi

doi:10.1271/bbb.110104

Cited by 18 publications

(21 citation statements)

References 27 publications

(25 reference statements)

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“…Fx also suppressed degranulation in rat basophilic leukemia (RBL)-2H3 cells via highaffinity IgE receptor (FcεRI)-mediated intracellular signaling, such as the phosphorylation of Lyn kinase and Fyn kinase (Sakai et al, 2009). In in vivo experiments, intravenously or orally administered Fx suppressed footpad inflammation induced by LPS and the infiltration of inflammatory cells in rat and mouse ear swelling induced by 2,4-dinitrofluorobenzene (DNFB) (Shiratori et al, 2005;Sakai et al, 2011). Fx also exerted an immunomodulatory effect by suppressing T cell differentiation into Th17 cells, leading to the inhibition of inflammatory disease associated with Th17 cells (Kawashima, 2011).…”

Section: Recently Anti-inflammatory and Immunomodulatory Effects Ofmentioning

confidence: 99%

“…However, although the anti-inflammatory effect of Fx on DNFB-induced mouse ear swelling has been reported (Sakai et al, 2011), studies of different inflammation types (rapid or delayed) have not been performed. In addition, although inflammation in mouse ear swelling is attributed to reactions of the arachidonic acid (AA) cascade (Meurer et al, 1988;Rao et al, 1993), further studies on the involvement of the cascade in Fx-mediated anti-inflammatory reactions are currently lacking.…”

Section: Recently Anti-inflammatory and Immunomodulatory Effects Ofmentioning

confidence: 99%

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The Suppressive Effect of a Marine Carotenoid, Fucoxanthin, on Mouse Ear Swelling through Regulation of Activities and mRNA Expression of Inflammation-associated Enzymes

Sugiura

Kinoshita

Usui

et al. 2016

FSTR

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Section: Recently Anti-inflammatory and Immunomodulatory Effects Ofmentioning

confidence: 99%

Section: Recently Anti-inflammatory and Immunomodulatory Effects Ofmentioning

confidence: 99%

The Suppressive Effect of a Marine Carotenoid, Fucoxanthin, on Mouse Ear Swelling through Regulation of Activities and mRNA Expression of Inflammation-associated Enzymes

Sugiura

Kinoshita

Usui

et al. 2016

FSTR

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“…Interestingly, these carotenoids inhibited antigen-induced translocation of FcεRI to lipid rafts, which are known as platforms of the aggregation of FcεRI [42]. Furthermore, oral administration of these four carotenoids for a week significantly inhibited dinitrofluorobenzene (DNFB)-induced ear swelling and the increased content of histamine in the DNFB-treated mice [43]. These results suggested that dietary carotenoids exert an anti-inflammatory effect by suppressing mast cell degranulation in vivo .…”

Section: Anti-inflammatory Effectmentioning

confidence: 99%

Siphonaxanthin, a Green Algal Carotenoid, as a Novel Functional Compound

Sugawara

Ponesakki

et al. 2014

Marine Drugs

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Siphonaxanthin is a specific keto-carotenoid in green algae whose bio-functional properties are yet to be identified. This review focuses on siphonaxanthin as a bioactive compound and outlines the evidence associated with functionality. Siphonaxanthin has been reported to potently inhibit the viability of human leukemia HL-60 cells via induction of apoptosis. In comparison with fucoxanthin, siphonaxanthin markedly reduced cell viability as early as 6 h after treatment. The cellular uptake of siphonaxanthin was 2-fold higher than fucoxanthin. It has been proposed that siphonaxanthin possesses significant anti-angiogenic activity in studies using human umbilical vein endothelial cells and rat aortic ring. The results of these studies suggested that the anti-angiogenic effect of siphonaxanthin is due to the down-regulation of signal transduction by fibroblast growth factor receptor-1 in vascular endothelial cells. Siphonaxanthin also exhibited inhibitory effects on antigen-induced degranulation of mast cells. These findings open up new avenues for future research on siphonaxanthin as a bioactive compound, and additional investigation, especially in vivo studies, are required to validate these findings. In addition, further studies are needed to determine its bioavailability and metabolic fate.

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“…In particular, the marine carotenoid, fucoxanthin, has multiple functions and has been reported to have considerable potential for applications for improving human health [7,8,9,10,11,12]. For example, fucoxanthin induces the uncoupling of protein 1 expression in white adipose tissue mitochondria [7].…”

Section: Introductionmentioning

confidence: 99%

“…Sakai et al [8] reported that fucoxanthin, astaxanthin, zeaxanthin and β-carotene significantly inhibit the antigen-induced release of β-hexosaminidase in basophilic leukemia 2H3 and mast cells and that these carotenoids also inhibit antigen-induced aggregation of the high affinity IgE receptor on mast cells. Further, Sakai et al [10] reported that these carotenoids inhibit dinitrofluorobenzene-induced contact hypersensitivity in the ears by reducing the TNF-α and histamine levels in the ear.…”

Section: Introductionmentioning

confidence: 99%

Peridinin from the Marine Symbiotic Dinoflagellate, Symbiodinium sp., Regulates Eosinophilia in Mice

et al. 2014

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Peridinin and fucoxanthin, which are natural carotenoids isolated from a symbiotic dinoflagellate, Symbiodinium sp., and a brown alga, Petalonia fascia, respectively, were compared for inhibitory effects on delayed-type hypersensitivity in mice. The number of eosinophils at the site of inflammation and in peripheral blood was compared for the administration of peridinin and fucoxanthin applied by painting and intraperitoneally. Peridinin, but not the structurally-related fucoxanthin, significantly suppressed the number of eosinophils in both the ear lobe and peripheral blood. Furthermore, peridinin applied topically, but not administered intraperitoneally, suppressed the level of eotaxin in the ears of sensitized mice. Fucoxanthin weakly suppressed the concentration of eotaxin in ears only by intraperitoneal administration. Although both carotenoids inhibited the migration of eosinophils toward eotaxin, the inhibitory effect of peridinin was higher than that of fucoxanthin. Peridinin may be a potential agent for suppressing allergic inflammatory responses, such as atopic dermatitis, in which eosinophils play a major role in the increase of inflammation.

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Inhibitory Effect of Dietary Carotenoids on Dinitrofluorobenzene-Induced Contact Hypersensitivity in Mice

Cited by 18 publications

References 27 publications

The Suppressive Effect of a Marine Carotenoid, Fucoxanthin, on Mouse Ear Swelling through Regulation of Activities and mRNA Expression of Inflammation-associated Enzymes

The Suppressive Effect of a Marine Carotenoid, Fucoxanthin, on Mouse Ear Swelling through Regulation of Activities and mRNA Expression of Inflammation-associated Enzymes

Siphonaxanthin, a Green Algal Carotenoid, as a Novel Functional Compound

Peridinin from the Marine Symbiotic Dinoflagellate, Symbiodinium sp., Regulates Eosinophilia in Mice

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