Inhibitory Effect of .DELTA.-Tocotrienol, a HMG CoA Reductase Inhibitor, on Monocyte-Endothelial Cell Adhesion.

Chao, Jun-Tzu; Gapor, Abdul; Theriault, André

doi:10.3177/jnsv.48.332

Cited by 32 publications

(13 citation statements)

References 29 publications

(1 reference statement)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The -tocotrienol is also effective for reducing endothelial expression of adhesion molecules, thereby preventing the accumulation of inflammatory cells within the arterial wall and inhibits the excessive aggregation of blood platelets [121,122].…”

Section: Antiatherogenic Effectmentioning

confidence: 99%

The 21st Century Form of Vitamin E - Tocotrienol

Bardhan¹,

Chakraborty²,

Raychaudhuri

2011

CPD

View full text Add to dashboard Cite

Vitamin E family constitutes of tocopherol and tocotrienol. Each form has several isomers: alpha,beta, gamma, delta, desmo and didesmo. Although tocopherol is known much earlier, tocotrienol has been discovered more recently.Tocotrienol has higher antioxidant potential than tocopherol. Research shows that tocotrienol can inhibit the induced oxidative damage to lipids and proteins. Cholesterol biosynthesis pathway requires HMG Co A reductase. Tocotrienol degrades HMG Co A reductase protein and in turn lowers cholesterol synthesis. Tocotrienol can reverse ischemia-reperfusion which mediates cardiac dysfunction and induces c-Src protein expression. Tocotrienol prevents oxytosis and offers protection against Alzheimer's disease, Parkinson's disease, Hungtington's disease. Tocotrienol exerts anticancer property through cell cycle arrest, induction of apoptosis, inhibition of angiogenesis; antitumor activity. Tocotrienol also possesses anti-inflammatory, antidiabetic, antiadipogenic and antiatherogenic effect.

show abstract

Section: Antiatherogenic Effectmentioning

confidence: 99%

The 21st Century Form of Vitamin E - Tocotrienol

Bardhan¹,

Chakraborty²,

Raychaudhuri

2011

CPD

View full text Add to dashboard Cite

show abstract

“…Tocotrienols’ cardioprotective effects are mediated through their antioxidant mechanisms and their ability to suppress inflammation, and inhibit HMG-CoA reductase, a rate-limiting enzyme in cholesterol biosynthesis [66, 67, 95, 96], and reduce the expression of adhesion molecules and monocyte-endothelial cell adhesion [97]. …”

Section: In Vitro Studiesmentioning

confidence: 99%

Tocotrienols, the vitamin E of the 21st century: Its potential against cancer and other chronic diseases

Aggarwal

Sundaram

Prasad

et al. 2010

Biochemical Pharmacology

497

382

View full text Add to dashboard Cite

Initially discovered in 1938 as a "fertility factor," vitamin E now refers to eight different isoforms that belong to two categories, four saturated analogues (α, β, γ, and δ) called tocopherols and four unsaturated analogues referred to as tocotrienols. While the tocopherols have been investigated extensively, little is known about the tocotrienols. Very limited studies suggest that both the molecular and therapeutic targets of the tocotrienols are distinct from those of the tocopherols. For instance, suppression of inflammatory transcription factor NF-κB, which is closely linked to tumorigenesis and inhibition of HMG-CoA reductase, mammalian DNA polymerases and certain protein tyrosine kinases, is unique to the tocotrienols. This review examines in detail the molecular targets of the tocotrienols and their roles in cancer, bone resorption, diabetes, and cardiovascular and neurological diseases at both preclinical and clinical levels. As disappointment with the therapeutic value of the tocopherols grows, the potential of these novel vitamin E analogues awaits further investigation.

show abstract

“…Moreover, α-tocotrienol and α-tocopherol bind directly to 5-lipoxygenase (5-Lox) and inhibit 5-Lox independent of its antioxidant property [154]. It is also reported that tocotrienols inhibit monocyte binding to endothelial cells and inhibit induction of expression of endothelial cell adhesion molecules including VCAM-1 [155-159]. Furthermore, α-tocopherol blocks TNFα activation of MAPK/ERK pathway in airway epithelial cells [152].…”

Section: Reports Conflict Regarding Tocopherol Regulation Of Mediatormentioning

confidence: 99%

Isoforms of Vitamin E Differentially Regulate Inflammation

Cook‐Mills¹,

McCary²

2010

EMIDDT

View full text Add to dashboard Cite

Vitamin E regulation of disease has been extensively studied in humans, animal models and cell systems. Most of these studies focus on the α-tocopherol isoform of vitamin E. These reports indicate contradictory outcomes for anti-inflammatory functions of the α-tocopherol isoform of vitamin E, especially with regards to clinical studies of asthma and atherosclerosis. These seemingly disparate clinical results are consistent with recently reported unrecognized properties of isoforms of vitamin E. Recently, it has been reported that physiological levels of purified natural forms of vitamin E have opposing regulatory functions during inflammation. These opposing regulatory functions by physiological levels of vitamin E isoforms impact interpretations of previous studies on vitamin E. Moreover, additional recent studies also indicate that the effects of vitamin E isoforms on inflammation are only partially reversible using physiological levels of a vitamin E isoform with opposing immunoregulatory function. Thus, this further influences interpretations of previous studies with vitamin E in which there was inflammation and substantial vitamin E isoforms present before the initiation of the study. In summary, this review will discuss regulation of inflammation by vitamin E, including alternative interpretations of previous studies in the literature with regards to vitamin E isoforms.

show abstract

Inhibitory Effect of .DELTA.-Tocotrienol, a HMG CoA Reductase Inhibitor, on Monocyte-Endothelial Cell Adhesion.

Cited by 32 publications

References 29 publications

The 21st Century Form of Vitamin E - Tocotrienol

The 21st Century Form of Vitamin E - Tocotrienol

Tocotrienols, the vitamin E of the 21st century: Its potential against cancer and other chronic diseases

Isoforms of Vitamin E Differentially Regulate Inflammation

Contact Info

Product

Resources

About