Inhibitory Effect of Aluminum on Fissure Caries Formation in Rats (Short Communication)

Kleber, Carl J.; Putt, Mark S.

doi:10.1159/000261427

Cited by 7 publications

(3 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results of this study demonstrated that topical applications of A1 solutions, ranging in concentration from 100 to 4000 parts/106 AI, significantly inhibit caries formation in the rat. This corroborates the findings of other studies that topically applied Al, in the absence of F, is cariostatically active in the rat in short-term (Regolati et af, 1969;Muhlemann and Regolati, 1974) and long-term (Kleber and Putt, 1992) studies. However, these prior investigations evaluated only fissure lesions in the presence of indigenous microflora.…”

Section: Discussionsupporting

confidence: 92%

“…Using a similar rat model, significant caries reductions were demonstrated by Al when applied in a paste for 3 weeks (Kinkel, 1968;Riethe, 1979). Because no rat studies have been reported in which topical A1 treatments were applied regularly for an extended period of time, the effect of daily applications of a 0.007 M A1 solution on fissure caries formation during an 1 I-week test period was investigated (Kleber and Putt, 1992). The results, which showed that at an equimolar concentration of AIC13 was as effective as SnF2, support the findings of the short-term rat experiments which demonstrated that topically-applied Al solutions reduced fissure caries.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of aluminum concentration on dental caries formation in the rat

Putt

Kleber

1995

Oral Diseases

View full text Add to dashboard Cite

OBJECTIVE: Topically applied aluminum (AI) reduced fissure caries in rats with indigenous microflora, but neither therapeutic activity nor concentration effects have been studied in animals infected with caries‐inducing bacteria. This study investigated the effects of solutions containing various Al concentrations on formation of smooth surface and sulcal caries in cariogenically challenged rats infected with Streptococcus sobrinus. METHODS: Weanling rats, inoculated with S. sobrinus, were randomly assigned to six groups which were topically treated twice daily with water (treatment control), a NaF solution of 100 parts/106 F (positive control), or AIK(SO4)2 solutions containing 100, 1000, 2000, or 4000 parts/106 Al. Rats were fed a high‐sucrose diet and distilied water ad libitum for 10 weeks, then the molars were scored for enamel and dentin caries. RESULTS: Relative to the water control, NaF and all Al solutions significantly reduced prevalence of both smooth‐surface and fissure caries. Protection by Al solutions was greater on smooth surfaces than sulcal areas. Al treatments reduced smooth surface scores by 49–7I% and sulcal scores by 27–53%. For all comparisons the protective effect of the 100 parts/106 Al solution was less than solutions containing 1000 parts/106 Al or more. NaF and all Al solutions also significantly reduced the extent of lesion penetration into dentin. CONCLUSIONS: Topically applied AI reduced the formation and progression of both smooth surface and Sul. cal caries and showed evidence of a dose response in a rat model infected with S. sobrinus.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Effect of aluminum concentration on dental caries formation in the rat

Putt

Kleber

1995

Oral Diseases

View full text Add to dashboard Cite

show abstract

“…PUTT & KLEBER report (3) that Al salts with inorganic anions reduce enamel dissolution in vitro more than NaF and SnF,, but Al Iactate and citrate have little effect. In an 11-wk experiment with rats, KLEBER & PUTT (4) found that treatment with 7 mM AlCl, or SnF, reduced the incidence of fissure lesions by 30%, as compared with the control, but did not reduce the severity of the lesions significantly.…”

mentioning

confidence: 99%

Effects of aluminum (III) and fluoride on the demineralization of bovine enamel: a longitudinal microradiographic study

Hook

Christoffersen

et al. 1994

European J Oral Sciences

View full text Add to dashboard Cite

Hook M, Christoffersen J, Christoffersen MR, Leonardsen ES, Rassing MR, Rostrup E: Effects of aluminum (III) and fluoride on the demineralization of bovine enatnel: a longitudinal mieroradiographie study. Seand J Dent Res 1994; 102: 198-201. © Munksgaard, 1994. Longitudinal microradiography has been used to determine inhibiting effects of aluminum (III), Al, and lluoride on mineral loss from slices of bovine enamel exposed to a demineralizing solution 4 h daily for 35 days. Inhibitor treatment was 5 min four times daily. For the remaining time, the samples were immersed in a neutral calcium phosphate solution which allowed neither remineralization nor demineralization. This study indicates that a 1-mM (27 ppm) solution of Al in a 0.1-M Iactate solution, pH 5, has an inhibitory effect on the in vitro demineralization of bovine enamel. Application of this solution alternating with 20 mM (380 ppm) fluoride gave the same total inhibition as treatment with 20 mM fluoride alone.... -

show abstract

An In Vitro Study of the Effect of Aluminum and the Combined Effect of Strontium, Aluminum, and Fluoride Elements on Early Enamel Carious Lesions

Koletsi-Kounari

Mamai-Homata²,

Diamanti³

2012

Biol Trace Elem Res

View full text Add to dashboard Cite

The purpose of this in vitro study was to evaluate the effect of aluminum and of combined strontium, aluminum, and fluoride treatments on enamel demineralization and remineralization. During a 6-day pH-cycling protocol, pre-softened bovine enamel slabs were immersed twice daily for 1 min in the following experimental solutions: (a) distilled water [W] (negative control); (b) 1,000 ppm F [F] (positive control); (c) 1,000 ppm Al [Al]; (d) 1,000 ppm Al,1,000 ppm F applied interchangeably [Al-F]; (e) 1,000 ppm Al, 1,000 ppm F, applied in sequential order [Al+F]; (f) combined 1,000 ppm Al and 150 ppm Sr [Al+Sr]; and (g) combined 150 ppm Sr and 1,000 ppm F [Sr+F]. Subsequently, the specimens were subjected to a 5-day acid resistance test. Lesions were evaluated quantitatively by performing surface microhardness and qualitatively by using polarized light microscopy. According to the results, solutions [Sr+F] and [Al-F] enhanced remineralization and inhibited demineralization as effectively as the [F] solution and significantly superiorly compared to [Al+Sr] and [Al] solutions. All tested solution groups, except for the [Al+Sr] group, presented significantly increased resistance to acidic attack, compared to [W]. PLM examination revealed that all solution groups, except for the [W] group, developed an acid-resistant zone at lesion surfaces. In conclusion, under the present experimental conditions, the combined strontium-fluoride and aluminum-fluoride treatments presented similar anti-caries efficacy compared to fluoride treatment alone, but they did not show evidence of synergistic activity on pre-softened enamel.

show abstract

Inhibitory Effect of Aluminum on Fissure Caries Formation in Rats (Short Communication)

Cited by 7 publications

References 8 publications

Effect of aluminum concentration on dental caries formation in the rat

Effect of aluminum concentration on dental caries formation in the rat

Effects of aluminum (III) and fluoride on the demineralization of bovine enamel: a longitudinal microradiographic study

An In Vitro Study of the Effect of Aluminum and the Combined Effect of Strontium, Aluminum, and Fluoride Elements on Early Enamel Carious Lesions

Contact Info

Product

Resources

About