Inhibitory activity of xanthine oxidase by fractions Crateva adansonii

Abdullahi, Aliyu A.; Hamzah, RU; Jigam, Ali A.; Yahya, Amina F.; Kabiru, Adamu Yusuf; Muhammad, Hadiza Lami; Sakpe, S; Adefolalu, Funmilola Sherifat; Isah, M. B.; Kolo, Matthew Tikpangi

doi:10.1016/s2221-6189(13)60029-3

Cited by 41 publications

(28 citation statements)

References 14 publications

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“…[75]. The assay mixture consisted of samples, phosphate buffer (pH: 7.5), and xanthine oxidase enzyme solution (0,1 U/mL in phosphate buffer, pH: 7.5) which was prepared immediately before use.…”

Section: -(Allylsulfinyl)-1344-tetrachloro-2-nitrobuta-13-diene mentioning

confidence: 99%

Synthesis and Biological Evaluation of S-Substituted Perhalo-2-nitrobuta-1,3-dienes as Novel Xanthine Oxidase, Tyrosinase, Elastase, and Neuraminidase Inhibitors

Onul

Ertik

Mermer

et al. 2018

Journal of Chemistry

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S-substituted perhalo-2-nitrobuta-1,3-dienes 3a, b were synthesized by the reaction of polyhalo-2-nitrobuta-1,3-dienes 1a, b with allyl mercaptan. 1-(2,3-Dibromopropanethio)-4-bromo-1,3,4-trichloro-2-nitrobuta-1,3-diene 4 was obtained from the addition of bromine to S-substituted polyhalo-2-nitrobuta-1,3-diene 3b in carbon tetrachloride. Sulfoxides 5a, b, and 6 were obtained from the reaction of thiosubstituted polyhalonitrobutadienes 3a, b, and 4 with m-CPBA in CHCl 3 . The structures of the new compounds were determined by spectroscopic data (FTIR, 1 H NMR, 13 C NMR, MS). These compounds exhibited antixanthine oxidase, antityrosinase, antielastase, and antineuraminidase activities.

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Section: -(Allylsulfinyl)-1344-tetrachloro-2-nitrobuta-13-diene mentioning

confidence: 99%

Synthesis and Biological Evaluation of S-Substituted Perhalo-2-nitrobuta-1,3-dienes as Novel Xanthine Oxidase, Tyrosinase, Elastase, and Neuraminidase Inhibitors

Onul

Ertik

Mermer

et al. 2018

Journal of Chemistry

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“…The presence of polyphenols and flavonoids in the extract can enhance XO inhibition. 36,37 Thus, the higher XO inhibitory effect of ChE and EaE can be due to their richness in flavonoids. XO causes hyperuricemia, gout and cardiovascular disease, and their inhibitors are considered effective drugs to control these uric acid-related problems.…”

Section: Effect Of Paronychia Argentea Extracts On Xo Activitymentioning

confidence: 99%

Study of the Antioxidant Property and Xanthine Oxidase Inhibitory Activity of Various Extracts from the Algerian Medicinal Plant Paronychia argentea L.

Adjadj¹,

Djarmouni²

2018

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Introduction: Paronychia argentea L. is used in traditional medicine to treat various diseases in Algeria especially kidney stones. This study was focused on the antioxidant and xanthine oxidase inhibitory activities of these plant extracts. Methods: The different extracts were prepared using solvents of increasing polarity, and their total polyphenols and flavonoids contents were determined using spectrophotomet ric methods. The antioxidant activities of Paronychia argentea extracts (PAE) were assessed by their inhibitory effect on xanthine oxidase (XO) and their scavenger ability on superoxide radical (O 2•-) generated by this enzyme. Results: The analysis PAE showed that ethyl-acetate extract (EaE) has the highest concentration of total phenolics and flavonoids compared with the chloroform extract (ChE) and the crude extract (CE). Results revealed that all PAE were effective in both XO inhibiting and superoxide radical scavenging, with the following order for the two assays: ChE > EaE > CE. Conclusion: This study provided evidence that PAE had interesting antioxidant potential which was confirmed using two enzymatic methods. Therefore, this plant could be used to treat gout and lot of diseases, where inhibition of XO and scavenging of superoxide radical are necessary.

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“…In vitro XO inhibitory activity XO inhibitory activity was performed based on Umamaheswari [17] and Abdullahi [18] with minor modification. 1 ml fraction (25-200 µg/ml) was mixed 0.9 ml phosphate buffer 50 mM (pH 7.5 at 25°C) and 0.1 ml XO enzyme solution (0.1 unit/ml in phosphate buffer, pH 7.5) and preincubated on for 15 minutes at 25°C.…”

Section: Ua Assaymentioning

confidence: 99%

Constituent and Antihyperuricemic Activity of Stelechocarpus Burahol Leaves Subfractions

Sunarni

Fidrianny²,

Iwo³

et al. 2017

Asian J Pharm Clin Res

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Objective: The goal of this research was to evaluate antihyperuricemic activity of Stelechocarpus burahol leaves subfractions and isolate its chemical constituent of active subfraction.Methods: Ethyl acetate fraction from S. burahol extract was subfractionated by vacuum liquid chromatography, and the active subfractions were further subfractionated by classic column chromatography using isocratic eluent, followed by isolated chemical constituent from active subfraction. Hyperuricemic rat model was induced by given potassium oxonate intraperitoneally. The inhibitory effect of subfractions on the xanthine oxidase (XO) activity was determined using ultraviolet-visible spectrophotometry method.Results: Subfractions E.3, E.4, and E.5 significantly (p<0.05) reduced the serum uric acid (UA) level 43%, 46%, and 33%, respectively. The E.3, E.4, and E.5 have showed very weak XO inhibitory activity. Subfraction E.3.2 and E.4.3 significantly (p<0.05) reduced the serum UA level 29% and 38%, respectively, however still very weak effect on XO activity. Chemical constituent which was isolated from subfraction E.4.3 was kaempferol-3-O-rhamnoside. Conclusion:The subfractions of ethyl acetate fraction had antihyperuricemic activity in vivo but less effect on XO activity in vitro. Isolated compound in active antihyperuricemic of subfraction E.4.3 was kaempferol-3-O-rhamnoside.

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Inhibitory activity of xanthine oxidase by fractions Crateva adansonii

Cited by 41 publications

References 14 publications

Synthesis and Biological Evaluation of S-Substituted Perhalo-2-nitrobuta-1,3-dienes as Novel Xanthine Oxidase, Tyrosinase, Elastase, and Neuraminidase Inhibitors

Synthesis and Biological Evaluation of S-Substituted Perhalo-2-nitrobuta-1,3-dienes as Novel Xanthine Oxidase, Tyrosinase, Elastase, and Neuraminidase Inhibitors

Study of the Antioxidant Property and Xanthine Oxidase Inhibitory Activity of Various Extracts from the Algerian Medicinal Plant Paronychia argentea L.

Constituent and Antihyperuricemic Activity of Stelechocarpus Burahol Leaves Subfractions

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