1999
DOI: 10.1080/109158199225783 View full text |Buy / Rent full text
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Abstract: N-acetyltransferase(NAT)-catalyzed reactions can result in activation or detoxi® cation of arylamine carcinogens. Studies were conducted to examine the dose effects of berberine on inhibition of growth versus arylamine NAT activities in strains of Helicobacter pylori collected from peptic ulcer patients. An inhibition-ofgrowth study on H. pylori demonstrated that berberine elicited a dose-dependent growth inhibition in the H. pylori cultures. The results on the NAT activity was determined using acetyl coenzyme… Show more

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“…Protoberberine alkaloids, which are regarded as the major active components of RC and CP [2,3], have been found to exhibit various biological activities, such as an antimicrobial effect [4], anti-inflammatory property [5], and inhibition of aldose reductase [6]. Particularly, berberine, the most predominant protoberberine alkaloid of RC and CP, has been commonly applied to treat gastrointestinal infections and inhibit the growth of Helicobacter pylori [7,8]. Recently, research has also shown that H. pylori is sensitive to the water extracts of RC and CP at relatively low concentrations with MIC 50 less than 7.8 and 31.2 mg/mL, respectively [9].…”
Section: Ahamentioning
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“…Protoberberine alkaloids, which are regarded as the major active components of RC and CP [2,3], have been found to exhibit various biological activities, such as an antimicrobial effect [4], anti-inflammatory property [5], and inhibition of aldose reductase [6]. Particularly, berberine, the most predominant protoberberine alkaloid of RC and CP, has been commonly applied to treat gastrointestinal infections and inhibit the growth of Helicobacter pylori [7,8]. Recently, research has also shown that H. pylori is sensitive to the water extracts of RC and CP at relatively low concentrations with MIC 50 less than 7.8 and 31.2 mg/mL, respectively [9].…”
Section: Ahamentioning
“…Berberine, as an active constituent of fruit, promoted releasing NO in the intestinal endothelium [16]. It showed inhibitory activity on H. pylori growth [17] and gastroprotective effect through modulating NO synthase (NOS) gene expression [19]. It also had protective activity against small intestinal injury and increased adenosine in the intestinal tissue [20].…”
Section: Edible Fruits and Spices For The Treatment Of Pu In Timmentioning
“…The gastroprotective properties of EA have been proven against various ulcer inducers [ 38 , 39 , 40 , 41 ]. The inhibitory action of EA is related to its antioxidant characteristics, the inhibitory action on the gastric H + , K + -ATPase and anti- H. pylori activity [ 39 , 41 , 42 ]. NSAIDs are main cause of peptic ulcers [ 43 ].…”
Section: Discussionmentioning