Biochemical Pharmacology volume 81, issue 3, P355-363 2011 DOI: 10.1016/j.bcp.2010.10.011 View full text
Katherine Ann Scott, John Barnes, Roger Clive Whitehead, Ian James Stratford, Karen Ann Nolan

Abstract: The enzyme NAD(P)H quinone oxidoreductase (NQO1) can function both as a detoxifying enzyme as well as chaperone protein. The latter property has been extensively characterized by the use of dicoumarol which inhibits the chaperone properties of NQO1 in cells. However, the use of this compound is compromised by its multiple "off-target" effects. Coumarin-based compounds that are more potent than dicoumarol as inhibitors of NQO1 in cells have been identified (Nolan et al., Biochem Pharmacol 2010;80:977-81). The p…

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