volume 18, issue 5, P379-382 1996
DOI: 10.1016/0141-0229(95)00138-7
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JoséA. Moreno, Francisco J. Montes, Jacinto Catalán, Miguel A. Galán

Abstract: The inhibition of D-amino acid oxidase by certain alpha-keto acids products of the reaction with D-amino acids, in particular alpha-keto acids that are analogs of the amino acids alanine, valine, leucine, phenylanaline, phenylglycine, tyrosine and tryptophan, is reported. All the alpha-keto acids assayed behaved as substrate competitive inhibitors of the enzyme. The relationship between the degree of inhibition and the structure of the inhibitor is discussed.