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Cited by 9 publications
(10 citation statements)
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References 8 publications
(9 reference statements)
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“…Exponentially growing S. pombe cells were treated with 10 mM caffeine for 15 min (Fig. 6B), which elicits a cellular response similar to nitrogen starvation (Rallis and Bahler 2013). Gene expression and splicing profiles were quantified by nRNA-seq and cytoplasmic mRNA-seq in three biological replicates.…”
Section: Failure To Splice Cotranscriptionally Reduces Cytoplasmic Mrmentioning
confidence: 99%
“…Exponentially growing S. pombe cells were treated with 10 mM caffeine for 15 min (Fig. 6B), which elicits a cellular response similar to nitrogen starvation (Rallis and Bahler 2013). Gene expression and splicing profiles were quantified by nRNA-seq and cytoplasmic mRNA-seq in three biological replicates.…”
Section: Failure To Splice Cotranscriptionally Reduces Cytoplasmic Mrmentioning
confidence: 99%
“…To alter mRNA levels globally, exponentially growing S. pombe cells were treated with 10 mM caffeine for 15 min (Fig. 6B), which elicits a cellular response similar to nitrogen starvation (Rallis and Bahler 2013). Gene expression and splicing profiles were quantified by nRNA-seq and cytoplasmic mRNA-seq for three biological replicates.…”
Section: Failure To Splice Co-transcriptionally Reduces Cytoplasmic Mmentioning
confidence: 99%
“…The mTOR (Target of Rapamycin) signaling pathway is activated by nutrients (glucose, amino and fatty acids), growth factors, cytokines, oxygen, hormones and many other signals [ 1 - 4 ]. In turn, mTOR stimulates cellular size growth and metabolism as well as differentiation-specific functions [ 3 - 19 ]. In cycling cells, mTOR drives mass growth.…”
Section: Introductionmentioning
confidence: 99%
“…Since mTOR is fully active in cell culture (high levels of mitogens, nutrients and oxygen), it is usually sufficient for a cell to get arrested, in order to become senescent [ 22 ]. Rapamycin (and other rapalogs), certain tumor suppressors, including p53, serum-withdrawal, hypoxia and contact inhibition all suppress geroconversion by deactivating mTOR [ 19 , 28 , 59 - 71 ], thus maintaining quiescence instead. And vice verse, growth factor receptors, Ras, Raf, MEK, PI3K and Akt, which all activate the mTOR/S6K/S6 pathway, are involved in cellular senescence and cancer [ 72 - 76 ].…”
Section: Introductionmentioning
confidence: 99%