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Cited by 27 publications
(17 citation statements)
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References 45 publications
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“…We now show that the nuclear CaMKIIδΒ activation, induced by ET-1 is dependent on nuclear IP3, corroborating previous finding showing that CaMKIIδΒ plays a key role in gene expression associated with cardiac hypertrophy [33]. The importance of our current results is also highlighted by other studies demonstrating that different transcription factors are dependent directly or indirectly on Ca 2+ in the nucleus [55,56]. Although, much has been learned to provide more insight on how nuclear IP3-dependent Ca 2+ release coordinates different cardiomyocyte hypertrophic signaling cascades, our current data uncover a specific role by which nuclear IP3 spatially control hypertrophic response.…”
Section: Discussionsupporting
confidence: 92%
“…We now show that the nuclear CaMKIIδΒ activation, induced by ET-1 is dependent on nuclear IP3, corroborating previous finding showing that CaMKIIδΒ plays a key role in gene expression associated with cardiac hypertrophy [33]. The importance of our current results is also highlighted by other studies demonstrating that different transcription factors are dependent directly or indirectly on Ca 2+ in the nucleus [55,56]. Although, much has been learned to provide more insight on how nuclear IP3-dependent Ca 2+ release coordinates different cardiomyocyte hypertrophic signaling cascades, our current data uncover a specific role by which nuclear IP3 spatially control hypertrophic response.…”
Section: Discussionsupporting
confidence: 92%
“…Several studies have previously shown that intranuclear Ca 2+ can regulate gene expression by directly binding to DNA or through regulation of transcription factors and their co-factors (Dobi and Agoston 1998;Chawla et al 1998;Pusl et al 2002;Thompson et al 2003). We identified using a modified environmental DPI-ELISA that Ca 2+ did indeed affect the binding of NFAT transcription factors to DNA during torpor.…”
Section: Discussionmentioning
confidence: 86%
“…In addition, reports of Ca 2+ signaling systems in the nucleus have substantially increased over the past two decades. Recent studies have clearly implicated that gene transcription and cell cycle progression are directly influenced by nucleoplasmic Ca 2+ signals (Hardingham et al, 1997;Nicotera and Rossi, 1994;Thompson et al, 2003). However, whether nuclear Ca 2+ signals are generated autonomously within nuclei or follow cytoplasmic Ca 2+ signals remains controversial (Bootman et al, 2009;Gerasimenko and Gerasimenko, 2004).…”
Section: Namentioning
confidence: 99%