Biochemical Pharmacology volume 79, issue 9, P1242-1250 2010 DOI: 10.1016/j.bcp.2009.12.014 View full text
Jing Zhou, Choon-Nam Ong, Gang-Min Hur, Han-Ming Shen

Abstract: Andrographolide (Andro), a diterpenoid lactone isolated from a traditional herbal medicine Andrographis paniculata, is known to possess potent anti-inflammatory and anticancer properties. In this study, we sought to examine the effect of Andro on signal transducer and activator of transcription 3 (STAT3) pathway and evaluate whether suppression of STAT3 activity by Andro could sensitize cancer cells to a chemotherapeutic drug doxorubicin. First, we demonstrated that Andro is able to significantly suppress both…

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