Biochemical Pharmacology volume 79, issue 6, P880-887 2010 DOI: 10.1016/j.bcp.2009.10.025 View full text
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Jun-Yan Liu, Jun Yang, Bora Inceoglu, Hong Qiu, Arzu Ulu, Sung-Hee Hwang, Nipavan Chiamvimonvat, Bruce D. Hammock

Abstract: Inflammation is a multi-staged process whose expansive phase is thought to be driven by acutely released arachidonic acid (AA) and its metabolites. Inhibition of cyclooxygenase (COX), lipoxygenase (LOX), or soluble epoxide hydrolase (sEH) is known to be anti-inflammatory. Inhibition of sEH stabilizes the cytochrome P450 (CYP450) products epoxyeicosatrienoic acids (EETs). Here we used a non-selective COX inhibitor aspirin, a 5-lipoxygenase activation protein (FLAP) inhibitor MK886, and a sEH inhibitor t-AUCB t…

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