2011
DOI: 10.1590/s0102-695x2011005000142
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Inhibition of Saccharomyces cerevisiae Pdr5p by a natural compound extracted from Brazilian Red Propolis

Abstract: Multidrug resistance of cancer cells and pathogenic microorganisms leading to the treatment failure of some forms of cancer or life-threatening bacterial or fungal infections is often caused by the overexpression of multidrug efflux pumps belonging to the ATP-binding cassette transporters superfamily. The multidrug resistance of fungal cells often involves the overexpression of efflux pumps belonging to the pleiotropic drug resistance (PDR) family of ABC transporters. Possibly the best-studied fungal PDR trans… Show more

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Cited by 10 publications
(10 citation statements)
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References 32 publications
(30 reference statements)
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“…According to literature, red propolis is active against yeasts ( Sacharomyces cerevisiae, C. albicans ) and could be an alternative way to solve the multi‐resistance problem to drugs, also being used as an adjuvant in the antifungal treatment with azoic drugs (Lotti et al . ). Superficial mycosis caused by different strains of Candida ( C. glabrata, C. albicans and C. tropicalis) are sensitive to treatments with propolis (Sforcin et al .…”
Section: Discussionmentioning
confidence: 97%
See 1 more Smart Citation
“…According to literature, red propolis is active against yeasts ( Sacharomyces cerevisiae, C. albicans ) and could be an alternative way to solve the multi‐resistance problem to drugs, also being used as an adjuvant in the antifungal treatment with azoic drugs (Lotti et al . ). Superficial mycosis caused by different strains of Candida ( C. glabrata, C. albicans and C. tropicalis) are sensitive to treatments with propolis (Sforcin et al .…”
Section: Discussionmentioning
confidence: 97%
“…Red propolis has several confirmed biological activities, such as: antimicrobial and antifungal (Siqueira et al 2002;Trusheva et al 2006;Alencar et al 2007;Cabral et al 2009;Lotti et al 2011;Oldoni et al 2011;Righi et al 2011), antioxidant (Alencar et al 2007Cabral et al 2009;Izuta et al 2009a;Oldoni et al 2011;Righi et al 2011), cytotoxic (Alencar et al 2007Awale et al 2008;Li et al 2008;Izuta et al 2009b;Nunes et al 2009;Daleprane et al 2012a,b;Franchi et al 2012;Iio et al 2012;Kamiya et al 2012;Frozza et al 2013), antiparasitic (Ayres et al 2007), hepatoprotective (Rodriguez et al 1997), anti-inflammatory, analgesic and antipsoriasic (Led on et al 1996), wound healing (Albuquerque-J unior et al 2009) and helps to control the lipoprotein metabolism (Iio et al 2010). However, once there are differences in the composition of samples of red propolis (L opez et al 2014), these activities might not be present in all types of red propolis.…”
Section: Introductionmentioning
confidence: 99%
“…Many chemicals cause apoptosis in S. cerevisiae such as glucose, acetic acid and propolis (Sukhanova et al, 2011). The process of apoptosis occurring in S. cerevisiae has been described by Lotti et al (2011). Cytochrome c, but not endonuclease G (Nuc1p), was involved in the propolis-mediated cell death in S. cerevisiae .…”
Section: Scerevisiae Apoptosis Inductionmentioning
confidence: 99%
“…All propolis extracts inhibited the growth of isolates presenting a dose-dependent response pattern and antifungal resistance, in concordance with our results. The fungicidal and fungistatic activities of Brazilian green and red propolis extracts are also reportedly observed for other fungi genera, such as Saccharomyces (63) and Trichophyton (64-67).…”
Section: Discussionmentioning
confidence: 81%