Inhibition of protein synthesis in rat primary hepatocytes by extracts of Fusarium moniliforme-contaminated corn

Development of an L6 myoblast in vitro model of moniliformin toxicosis

“…This hypothesis was not supported by the data in this study. As noted in another study [28], monilifonnin did not inhibit protein synthesis. Results of the ATP assay were variable and recovery of ATP was low, especially in spiked cell pellets, suggesting that the processing of these samples allowed for continued consumption and/or degradation of ATP, most likely residual ATPase activity [29].…”

Development of an L6 myoblast in vitro model of moniliformin toxicosis

“…This hypothesis was not supported by the data in this study. As noted in another study [28], monilifonnin did not inhibit protein synthesis. Results of the ATP assay were variable and recovery of ATP was low, especially in spiked cell pellets, suggesting that the processing of these samples allowed for continued consumption and/or degradation of ATP, most likely residual ATPase activity [29].…”

Fumonisin-Contaminated Dietary Corn Reduced Survival and Antibody Production by Channel Catfish Challenged withEdwardsiella ictaluri

“…The role of fumonisins in immunosuppression is not understood. Norred et al (1990Norred et al ( . 1992 suggested that the toxins from F. monilifonne inhibit synthesis of proteins functional in immune responses, based upon their determination that these 7…”

Fusarium : a treasure trove of bioactive secondary metabolites

“…19 According to the differences in the nitrogen function and the length of the carbon backbone, fumonisins are traditionally divided into four groups (A, B, C and P fumonisins), and with fumonisins B being the most important in terms of isolation yield and toxicity. 20 Fumonisins are also strong inhibitors of protein synthesis and ceramide synthetase, 21,22 and can induce chromosomal aberrations in rat hepatocytes followed by hepatocarcinoma. 23,24 Biosynthetically, the production of fumonisins is regulated by 17 coordinated genes (Fig.…”

Development of an L6 myoblast in vitro model of moniliformin toxicosis

“…This hypothesis was not supported by the data in this study. As noted in another study [28], monilifonnin did not inhibit protein synthesis. Results of the ATP assay were variable and recovery of ATP was low, especially in spiked cell pellets, suggesting that the processing of these samples allowed for continued consumption and/or degradation of ATP, most likely residual ATPase activity [29].…”

Fumonisin-Contaminated Dietary Corn Reduced Survival and Antibody Production by Channel Catfish Challenged withEdwardsiella ictaluri

“…The role of fumonisins in immunosuppression is not understood. Norred et al (1990Norred et al ( . 1992 suggested that the toxins from F. monilifonne inhibit synthesis of proteins functional in immune responses, based upon their determination that these 7…”

Fusarium : a treasure trove of bioactive secondary metabolites

“…19 According to the differences in the nitrogen function and the length of the carbon backbone, fumonisins are traditionally divided into four groups (A, B, C and P fumonisins), and with fumonisins B being the most important in terms of isolation yield and toxicity. 20 Fumonisins are also strong inhibitors of protein synthesis and ceramide synthetase, 21,22 and can induce chromosomal aberrations in rat hepatocytes followed by hepatocarcinoma. 23,24 Biosynthetically, the production of fumonisins is regulated by 17 coordinated genes (Fig.…”

Development of an L6 myoblast in vitro model of moniliformin toxicosis

“…This hypothesis was not supported by the data in this study. As noted in another study [28], monilifonnin did not inhibit protein synthesis. Results of the ATP assay were variable and recovery of ATP was low, especially in spiked cell pellets, suggesting that the processing of these samples allowed for continued consumption and/or degradation of ATP, most likely residual ATPase activity [29].…”

Fumonisin-Contaminated Dietary Corn Reduced Survival and Antibody Production by Channel Catfish Challenged withEdwardsiella ictaluri

“…The role of fumonisins in immunosuppression is not understood. Norred et al (1990Norred et al ( . 1992 suggested that the toxins from F. monilifonne inhibit synthesis of proteins functional in immune responses, based upon their determination that these 7…”

Fusarium : a treasure trove of bioactive secondary metabolites

“…19 According to the differences in the nitrogen function and the length of the carbon backbone, fumonisins are traditionally divided into four groups (A, B, C and P fumonisins), and with fumonisins B being the most important in terms of isolation yield and toxicity. 20 Fumonisins are also strong inhibitors of protein synthesis and ceramide synthetase, 21,22 and can induce chromosomal aberrations in rat hepatocytes followed by hepatocarcinoma. 23,24 Biosynthetically, the production of fumonisins is regulated by 17 coordinated genes (Fig.…”