Inhibition of photosystem II electron transport and structure-activity relationships among herbicidally active 3-butenanilides

Eilers, R.J.; Crouse, Gary D.; Durst, Gregory L.; Manly, Charles J.; Webster, Jeanette; Streusand, V. J.

doi:10.1016/0048-3575(92)90030-4

Cited by 4 publications

(1 citation statement)

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“…Oettmeier et al [42] studied the SAR of triazinone herbicides on resistant weeds and resistant Chlamydomonas reinhardtii. Inhibition of photosystem II electron transport and SAR among herbicidally active 3-butenanilides were studied by Eilers et al [43]. A 3D-QSAR study of anticoccidial triazines using the molecular shape analysis had been performed by Rhyu et al [44].…”

Section: Quantitative Structure-activity Relationship (Qsar) Analysismentioning

confidence: 99%

Toxicity Assessment of Atrazine and Related Triazine Compounds in the Microtox Assay, and Computational Modeling for Their Structure-Activity Relationship

Tchounwou

Wilson

Ishaque

et al. 2000

IJMS

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The triazines are a group of chemically similar herbicides including atrazine, cyanazine, and propazine, primarily used to control broadleaf weeds. About 64 to 80 million lbs of atrazine alone are used each year in the United States, making it one of the two most widely used pesticides in the country. All triazines are somewhat persistent in water and mobile in soil. They are among the most frequently detected pesticides in groundwater. They are considered as possible human carcinogens (Group C) based on an increase in mammary gland tumors in female laboratory animals. In this research, we performed the Microtox Assay to investigate the acute toxicity of a significant number of triazines including atrazine, atraton, ametryne, bladex, prometryne, and propazine, and some of their degradation products including atrazine desethyl, atrazine deisopropyl, and didealkyled triazine. Tests were carried out as described by Azur Environmental [1]. The procedure measured the relative acute toxicity of triazines, producing data for the calculation of triazine concentrations effecting 50% reduction in bioluminescence (EC 50 s). Quantitative structure-activity relationships (QSAR) were examined based on the molecular properties obtained from quantum mechanical predictions performed for each compound. Toxicity tests yielded EC 50

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Section: Quantitative Structure-activity Relationship (Qsar) Analysismentioning

confidence: 99%