1994
DOI: 10.1007/bf00302664 View full text |Buy / Rent full text
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Abstract: As mononuclear cell infiltration and growth of pannus critically depend on synovial neovascularization in rheumatoid arthritis (RA), inhibition of the synovial blood vessels would have the potential to reduce rheumatoid inflammation. In this investigation, we studied the effect of gold sodium thiomalate (GST) and auranofin (AUR) on neovascularization in vivo by using a micropocket technique. Both GST and AUR suppressed rabbit corneal neovascularization in a dose-dependent fashion. Significant inhibition was ob… Show more

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“…As to the duration of the release of bFGF from the pellet, it seems unlikely that biological activity was maintained for more than 3 weeks in an intra-articular milieu [1,25]. Furthermore, enhancement of the healing process afforded by bFGF in this study was demonstrated mainly in the initial stage of healing.…”
Section: Discussionmentioning
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“…As to the duration of the release of bFGF from the pellet, it seems unlikely that biological activity was maintained for more than 3 weeks in an intra-articular milieu [1,25]. Furthermore, enhancement of the healing process afforded by bFGF in this study was demonstrated mainly in the initial stage of healing.…”
Section: Discussionmentioning
“…It has already been shown that the release of several proteins from this pellet was maintained for about 6 weeks in a culture medium environment [16]. Additionally, in a study using the in vivo corneal micropocket technique [1,25], angiogenesis of the corneal microvasculature was found to continue for about 3 weeks with the use of these bFGF-impregnated pellets. Since the pellets which contained less than 1 µg bFGF had a minimal effect in a pilot study of the same experimental model, it was decided that 10 µg bFGF would be added to each pellet.…”
Section: Methodsmentioning
“…AF has been shown to directly inhibit neovascularization, which would result in decreased blood supply to neoplasms (Saura et al 1994). A molecular basis for this activity could be inhibition of TLR-3 activation and signalling ).…”
Section: Anti-neoplastic Propertiesmentioning