Burkhard Gess, Hartmut Halfter, Ilka Kleffner, Paula Monje, Gagani Athauda, Patrick M. Wood, Peter Young, Ina B. Wanner
Abstract:N-cadherin and beta-catenin are involved in cell adhesion and cell cycle in tumor cells and neural crest. Both are expressed at key stages of Schwann cell (SC) development, but little is known about their function in the SC lineage. We studied the role of these molecules in adult rat derived SC-embryonic dorsal root ganglion cocultures by using low-Ca(2+) conditions and specific blocking antibodies to interfere with N-cadherin function and by using small interfering RNA (siRNA) to decrease beta-catenin express…
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