volume 17, issue 1, P33-36 1993
DOI: 10.1111/j.1472-765x.1993.tb01429.x
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Abstract: [14C]acetate was incorporated into mycolic acids by a cell‐free, cell‐wall fraction from Mycobacterium smegmatis. This activity was inhibited by methyl 4‐(2‐octadecylcyclopropen‐1‐y1) butanoate which was designed as a structural analogue of cis‐tetracos‐5‐enoate, a precursor of mycolic acid biosynthesis. Other fatty acids and their methyl esters failed to inhibit mycolic acid biosynthesis at the concentration 1–2 mg ml‐1, at which methyl 4‐(2‐octadecylcyclopropen‐1‐y1) butanoate was effective. Thus a novel ag…

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