Inhibition of melanoma brain metastasis by targeting melanotransferrin at the cell surface

Rolland, Yannève; Demeule, Michel; Fénart, Laurence; Béliveau, Richard

doi:10.1111/j.1755-148x.2008.00525.x

Cited by 65 publications

(53 citation statements)

References 46 publications

(73 reference statements)

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“…Feng and others have hypothesized that matrix metalloproteinases secreted by leukemic cells may facilitate the breakdown of the blood-brain barrier (BBB), which may lead to seeding of the CSF during transient bacteremia (20). Additionally, melanoma is known to disrupt the BBB, and in our patient, disruption of the BBB by metastatic melanoma might have facilitated P. acnes to enter the CSF; however, it is unclear why P. acnes and not another organism might cause disease in this setting (21,22). While many scenarios could be hypothesized, one possible explanation is that the patient had a transient P. acnes bacteremia after his lower-extremity biopsy 8 weeks prior to admission that resulted in seeding of the CSF.…”

Section: Case Reportmentioning

confidence: 71%

De Novo Meningitis Caused by Propionibacterium acnes in a Patient with Metastatic Melanoma

et al. 2014

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Propionibacterium acnes is a known cause of postneurosurgical meningitis; however, it is rarely implicated in de novo meningitis. Herein we report a case of a 49-year-old male with de novo meningitis caused by P. acnes with metastatic melanoma as the only identified risk factor for his infection. CASE REPORTA 49-year-old Caucasian male presented to his primary care physician with an 11-week history of bifrontal headaches associated with nausea and emesis but without other symptoms of meningismus. Symptomatic relief was provided with over-thecounter pain medications and antiemetics. Five weeks prior to arrival at our institution, the patient was admitted to an outside hospital for intractable vomiting and headaches. A computed tomography (CT) scan of the head and abdomen were performed, both of which were normal. Two weeks prior to admission, his headache and nausea worsened with the onset of subjective fevers, low back pain, lethargy, and confusion.Roughly 2 years prior to admission, the patient was diagnosed with stage IIIC melanoma of the right lower extremity, for which he underwent resection and lymphadenectomy. In the intervening period, he was thought to be in remission. Eight weeks prior to admission, a left-lower-extremity skin biopsy specimen demonstrated a melanocytic nevus.At the time of admission, his vital signs were as follows: temperature, 36.7°C; blood pressure, 168/92 mm Hg; heart rate, 87 beats per minute; respiratory rate, 20 breaths per minute; oxygen saturation of 98% on room air; height, 188 cm (74 in.); and weight, 142 kg (312.4 lb). The physical exam showed a well-developed male in no acute distress, alert, and oriented to place, year, self, and situation. Notable findings included right-lower-extremity swelling, a healed scar at the site of his prior melanoma, and ecchymosis surrounding a left-lower-extremity biopsy site. He did not have signs of meningismus.Laboratory findings on admission included a hemoglobin level of 14.1 g/dl, hematocrit of 40.3%, white blood cell count of 10,300/mm 3 , mildly elevated absolute neutrophil count of 7,600/ mm 3 (range, 1,800 to 6,600/mm 3 ), normal chemistry panel, an alanine transaminase level of 89 U/liter (range, 7 to 53 U/liter) but otherwise normal hepatic function panel, and a normal urinalysis.A repeat CT scan of the head was obtained on hospital day 2, 5 weeks after the prior scan, which revealed a communicating hydrocephalus. CT myelography was also performed on day 2, which showed clumping of the nerve roots within the lumbar spine and nodular thickening surrounding L2-L3 nerve roots consistent with arachnoiditis versus metastatic disease.A fluoroscopically guided lumbar puncture (LP) was performed on hospital day 2, which yielded clear, yellow cerebrospinal fluid (CSF) with a glucose concentration of 26 mg/dl (serum glucose, 96 mg/dl), protein concentration of 518 mg/dl, 145 nucleated cells/l (1% neutrophils, 32% macrophages, 10% monocytes, 6% lymphocytes, and 51% unclassified cells due to poor cell viability), 576 red blood cells/l, and an...

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Section: Case Reportmentioning

confidence: 71%

De Novo Meningitis Caused by Propionibacterium acnes in a Patient with Metastatic Melanoma

et al. 2014

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“…First, large hydrophilic molecules, including many chemotherapeutic, are excluded from the CNS unless they can be actively transported by receptor-mediated transcytosis (58). Moreover, endothelial prognostic indicator for the development of brain metastases among patients with malignant melanoma (64). Another study reported that signal transducer and activator of transcription 3 (STAT3) activity was markedly elevated in human brain metastatic melanoma cells compared with cutaneous melanoma cells, suggesting close association between STAT3 expression and melanoma cell migration to the brain (19).…”

Section: Resultsmentioning

confidence: 99%

“…In vitro studies have demonstrated that different types of melanoma cells reduced transendothelial electrical resistance of the endothelial cell monolayer, indicating that specific tumor cells can modulate junctional integrity (22). It was also reported that the ability of melanoma cells to pass through the BBB corresponds closely with melanotransferrin (MTf) expression (22,64). MTf is one of several antigens associated with the surface of melanoma cells.…”

Section: Extravasationmentioning

confidence: 99%

Blood-brain Barrier Remodeling during Brain Metastasis Formation

Wrobel

Toborek

2016

Mol Med

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Our understanding of the process of metastatic progression has improved markedly over the past decades, yet metastasis remains the most enigmatic component of cancer pathogenesis. This lack of knowledge has serious health-related implications, since metastasis is responsible for 90% of all cancer-related mortalities. The brain is considered a sanctuary site for metastatic tumor growth, where the blood-brain barrier (BBB) and other components of the brain microenvironment, provide protection to the tumor cells from immune surveillance, chemotherapeutics and other potentially harmful substances. The interactions between tumor cells and the brain microenvironment, principally brain vascular endothelium, are the critical determinants in their progression toward metastasis, dormancy, or clearance. This review discusses current knowledge of the biology of metastatic progression, with a particular focus on the tumor cell migration and colonization in the brain. online address: http://www.molmed.org

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“…[42] The process of transendothelial migration of melanoma cells has been further investigated by other in vitro studies showing that the ability of these cells to cross the BBB is related to melanotransferrin expression levels on the cell surface, to the fibrinolytic system and to serine proteases released by melanoma cells. [43][44][45] This accumulating evidence indicates that inflammatory stimuli cotribute to the formation of breaches in BBB and of a suitable surrounding in the brain parenchyma for cancer cells.…”

Section: Crossing the Bbbmentioning

confidence: 99%

Brain infiltration by cancer cells: different roads to the same target?

Paolillo¹,

Schinelli²

2015

J Cancer Metastasis Treat

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Brain infiltration by cancer cells is a complex process in which metastatic cells detached from the primary tumor must firstly survive in the blood flow, cross the blood brain barrier (BBB) and finally colonize a foreign microenvironment. The cells that successfully bypass the cellular barriers surrounding capillaries, proliferate to form micrometastasis and trigger the angiogenetic process. Different molecular mechanisms have been proposed to explain the metastatic behaviour of solid tumors that infiltrate brain tissue; in this review the most recent findings concerning mechanisms and genes potentially involved in brain metastasis, that differ according to primary tumor types, will be discussed. The three tumors that more frequently develop brain metastasis, lung cancer, breast cancer and melanoma, will be considered and, in addition, the role of BBB and the process of endothelial to mesenchymal transition in cancer metastasis will be briefly described.

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Inhibition of melanoma brain metastasis by targeting melanotransferrin at the cell surface

Cited by 65 publications

References 46 publications

De Novo Meningitis Caused by Propionibacterium acnes in a Patient with Metastatic Melanoma

De Novo Meningitis Caused by Propionibacterium acnes in a Patient with Metastatic Melanoma

Blood-brain Barrier Remodeling during Brain Metastasis Formation

Brain infiltration by cancer cells: different roads to the same target?

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