Inhibition of ligand–protein complex isomerization by some dopamine transporter inhibitors
S Kukk
Abstract:Kinetic analysis of the interaction of four Nsubstituted nortropane derivatives with the dopamine transporter was made to characterize the mechanism of the binding process. The kinetics were studied by radioligand binding experiments. It was found that the studied compounds initiate a slow isomerization process of the initially formed ligand-transporter complex, but at higher concentrations, the same compounds inhibit the isomerization process. The results suggest that the studied ligands interact with two dis… Show more
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