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Cited by 37 publications
(16 citation statements)
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“…27 In an earlier study we investigated the ability of host leucocytes to destroy tumour cells (tumour type-specific leucocytotoxicity) and observed it to be depressed for up to seven days after mastectomy with halothane anaesthesia. 13 A similar effect was also reported following surgery for Wilm's tumour with general anaesthesia.…”
Section: Discussionmentioning
confidence: 99%
“…27 In an earlier study we investigated the ability of host leucocytes to destroy tumour cells (tumour type-specific leucocytotoxicity) and observed it to be depressed for up to seven days after mastectomy with halothane anaesthesia. 13 A similar effect was also reported following surgery for Wilm's tumour with general anaesthesia.…”
Section: Discussionmentioning
confidence: 99%
“…26 Similarly cell-mediated cytotoxicity, an important defence against malignant cells, was also inhibited by exposure to 1.0 to 2.5 per cent halothane in vitro. 27 In another study thiopentone was seen to inhibit cytotoxicity reaction at the peak concentrations found during the induction of anaesthesia and also decrease PHA induced lymphoproliferation at higher concentrations of the agent. 28 Ketamine, droperidol, or lidocaine did not affect lymphocyte transformation at clinical concentrations, but were able to cause a depression at much higher concentrations.…”
Section: Anaesthesia and Lymphocyte Functionmentioning
confidence: 94%
“…46 Tumour cell killing by cytotoxic leucocytes was also inhibited by local anaesthetics,47 barbital4S and halothane in vitro. 27 Although it is difficult to assess the anaesthetic effects in isolation from surgical intervention, from the above studies it would appear that anaesthesia and surgery may enhance tumour spread by suppressing the immune responses.…”
Section: Anaesthesia and Malignancymentioning
confidence: 99%
“…However, it does not in¯uence the rejection of allogeneic skin graft, neutrophil migration, chemotaxis, phagocytosis, degranulation, and nonmitochondrial oxidative metabolism [Bruce and Wingard, 1969;Nunn et al, 1979;Yesilkaya et al, 1998]. Although nitrous oxide (N 2 O) reduces migration of human neutrophils, it has been found to enhance chemotaxis of polymorphonuclear leukocytes [Cullen et al, 1976;Hill et al, 1978;Nunn and O  'Mora  in, 1982]. Most of these observations are in vitro parameters of immune function or of partial modulation of in vivo correlates of the immune response.…”
Section: Introductionmentioning
confidence: 99%