Inhibition of bovine sperm-oocyte fusion by the carbohydrate GalNAc

Binding of Sperm to the Zona Pellucida Mediated by Sperm Carbohydrate-Binding Proteins is not Species-Specific in Vitro between Pigs and Cattle

“…A human sperm 65-kDa protein binds α-Man and is a candidate for an oolemma binding protein [25]. In cattle, α-Man and GalNAc inhibit sperm–oolemma fusion but do not inhibit binding [26,27]. In pigs, the involvement of carbohydrates in sperm–oolemma interaction has not yet been reported.…”

Vitronectin and Its Receptor (Integrin αvβ3) During Bovine Fertilization In Vitro

“…Even though substantial insights into these interactions have been elucidated in particular in human and mouse (Fusi et al 1992;1996a;1996b;Almeida et al 1995;Evans et al 1995;, a clear identification of the underlying mechanisms and molecules implicated in bovine fertilization is still required. The involvement of numerous carbohydrates and glycoproteins in adhesion and binding events during several reproductive processes has been described in ruminants, ranging from roles in spermoviduct adhesion (Revah et al 2000;Talevi & Gualtieri 2001;Sostaric et al 2005;Gwathmey et al 2006;Ignotz et al 2007), sperm-oocyte interactions (Gougoulidis et al 1999;Amari et al 2001;Tanghe et al 2004a;2004b) to embryo implantation (Spencer et al 2004).…”

A Bird's-Eye View of Veterinary Medicine

“…Even though substantial insights into these interactions have been elucidated in particular in human and mouse (Fusi et al 1992;Almeida et al 1995;Evans et al 1995;, a clear identification of the underlying mechanisms and molecules implicated in bovine fertilization is still required. The involvement of numerous carbohydrates and glycoproteins in adhesion and binding events during several reproductive processes has been described in ruminants, ranging from roles in spermoviduct adhesion (Revah et al 2000;Talevi & Gualtieri 2001;Sostaric et al 2005;Gwathmey et al 2006;Ignotz et al 2007), sperm-oocyte interactions (Gougoulidis et al 1999;Amari et al 2001;Tanghe et al 2004a; to embryo implantation (Spencer et al 2004).…”