DOI: 10.5772/intechopen.90614
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Angela Di Somma, Antonio Moretta, Carolina Canè, Arianna Cirillo, Angela Duilio

Abstract: Biofilm is a complex matrix consisting of extracellular polysaccharides, DNA, and proteins that protect bacteria from a variety of physical, chemical, and biological stresses allowing them to survive in hostile environments. Biofilm formation requires three different stages: cell attachment to a solid substrate, adhesion, and growth. The inhibition of one of these steps by small molecules, such as antimicrobial peptides, or their action on specific targets will leave pathogens armless against classical antibio…

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